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Levacetylmethadol

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Last Updated: 30 October 2020

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General | Latest Info

Levacetylmethadol

Chemical and physical data
3D model ( JSmol )Interactive image
FormulaC 23 H 31 N O 2
Molar mass353.498 gmol 1
Clinical data
ATC codeN07BC03 ( WHO )
Routes of administrationBy mouth
Trade namesOrLAAM
Identifiers
CAS Number1477-40-3 Y 43033-72-3 ( hydrochloride )
ChEMBLChEMBL1514 N
ChemSpider14401 N
CompTox Dashboard ( EPA )DTXSID3023211
DrugBank15130 N
IUPHAR/BPS7212
KEGGD04716 Y
PubChem CID15130
UNIIR3B637Y991
Legal status
Legal statusAU : S8 (Controlled drug), CA : Schedule I, DE : Anlage III (Special prescription form required), US : Schedule II
Pharmacokinetic data
Elimination half-life2.6 days
MetabolismCYP3A4
Protein binding~80%

Levacetylmethadol addiction treatment is available for those who feel they may have dependency or addiction to Levacetylmethadol. This drug is also know as Orlaam by brand name in the United States and on European market. It is a synthetic opioid that is used in treatment of opioid dependency, and it was approved in the early 90s for use by the US Food and Drug Administration. This drug is very similar to methadone and has been used to treat addictions such as those to heroin. In the early 2000s, Orlaam was discontinued in the US and in the European pharmaceutical market due to risk of life-threatening conditions, such as ventricular rhythm disorders. If you would like more information on Levacetylmethadol addiction treatment, call 1-888-287-0471 Who answer?. Our hotline can provide you with information on treatment centers, withdrawal symptoms, and any other information you need. Levacetylmethadol addiction treatment has been used in the past as treatment for patients who have form dependency on opioids, but who have not been able to stop with the help of methadone or buprenorphine. This treatment is a second-line medication, meaning it is unlikely to be used before other options have been exhaust. Prior to removal from the US market, Levacetylmethadol addiction treatment was classified as a Schedule I Drug. Levacetylmethadol detox and Levacetylmethadol rehab are dosed according to the needs of the patient, but is not dose above 120 mg on a regular basis. LAAM is an oral solution. If a patient has not been treated with methadone, it is likely that the first dose will be between 20 and 40 mg. However, if a patient was taking methadone prior to Levacetylmethadol addiction treatment, dosage will be slightly higher than methadone dosage to start. Levacetylmethadol addiction treatment is beneficial to patients because it does not have to be given every day like some other opioid detox treatments. Dosage is adjusted according to patients needs, but it is common to only take LAAM two or three times per week. If you or someone you know would like more information about Levacetylmethadol addiction treatment, Levacetylmethadol detox and / or Levacetylmethadol rehab, contact our 24-hour hotline at 1-888-287-0471 Who Answers?

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Medical uses

Orlaam other commonly used names are LAAM, LAM, levacetylmethadol, levo-alpha-acetylmethadol, levomethadyl acetate, and MK790. Opioid abuse therapy adjunct levomethadyl belongs to a group of medicines know as narcotic analgesics. It is used as a substitute for illegal narcotics in addiction treatment programs. This medicine is not a cure for addiction. It is used as part of an overall program that may include counseling, attending support group meetings, and other treatment recommended by your doctor. Levomethadyl helps prevent withdrawal symptoms that may occur when an addict stops using other narcotics. In detoxification programs, amount of levomethadyl used slowly decreases until the addict becomes drug-free. In maintenance programs, it is used on a long-term basis to help narcotic addicts stay away from street drugs. With long-term use, levomethadyl may decrease addict's craving for other narcotics. Another narcotic, Methadone, is also used in detoxification and maintenance programs. Methadone begins to work faster than levomethadyl does when treatment is start, but it has to be taken every day. Levomethadyl started to work slowly, but it does not have to be take every day. Therefore, some people may start treatment with Methadone and then change over to levomethadyl after several weeks. Other people may receive only one medicine or another during the entire time of treatment. Your doctor and your counselor at the clinic will decide on the best treatment plan for you. In the US, levomethadyl is available only in government-approve treatment clinics, in the following dosage form: Oral Oral solution in deciding to use medicine, risks of taking medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For levomethadyl, following should be consider: allergies Tell your doctor if you have ever had any unusual or allergic reaction to levomethadyl. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes. Pregnancy Methadone is the best medicine for treating pregnant narcotic addicts. Although there may be rare exceptions, levomethadyl is not recommended for use by pregnant women. Breathing problems and withdrawal symptoms are likely to occur in babies born to mothers who use levomethadyl during pregnancy. Also, although levomethadyl does not cause birth defects, it causes early deliveries and stillbirths in animal studies. In the US, law requires that women who may become pregnant must be give pregnancy tests before levomethadyl treatment starts and once a month during treatment. Breast-feeding It is not know whether levomethadyl passes into breast milk in amounts that may cause dependence or other side effects in nursing babies. Breast-feeding mothers who wish to use levomethadyl should discuss this with their doctor. Children in US, law does not allow levomethadyl to be used for treating addicts younger than 18 years of age. Older adults Many medicines have not been studied specifically in older people.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Pharmacology

Relative to fluconazole, propensity for and extent of drug-drug interactions are greater. Itraconazole is a substrate and noncompetitive inhibitor of CYP1A2, CYP3A4, and CYP3C9, and mediate P-glycoprotein-mediate efflux; P-glycoprotein is extensively colocalized and exhibits overlapping substrate specificity with CYP3A. Inhibition of CYP3A4 may lead to increased and potentially toxic concentrations of coadministered - drugs. Most important, coadministration of cisapride, pimozide, bepridil, mizolastine, terfenadine, astemizole, oral midazolam, quinidine, dofetilide, triazolam, sertindole, eletriptan, nisoldipine, and levacetylmethadol with itraconazole can lead to serious cardiac arrhythmias and is thus strictly contraindicate. Similarly, contraindicate is coadministration of certain cholesterol-lowering agents including atorvastatin, lovastatin, and simvastatin for risk of causing rhabdomyolysis, and ergot alkaloids metabolized by CYP3A4. Potentially toxic concentrations of coadministered drug also occur when it is given along with phenytoin, carbamazepine, benzodiazepines, cyclosporine, tacrolimus, sirolimus, methylprednisolone, budesonide, digoxin, warfarin, sulfonylurea compounds, ritonavir, indinavir, haloperidol, clarithromycin, verapamil, felodipine, busulfan, and vinca alkaloids. Increase metabolism of itraconazole resulting in decreased plasma levels can be induced by rifampin, rifabutin, isoniazid, carbamazepine, phenobarbital, and phenytoin. In patients who receive itraconazole along with one of the drugs listed here or in summary of product characteristics, plasma concentrations of both compounds and emerging toxicity should be monitored carefully.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Society and culture

Levacetylmethadol

Trade namesOrLAAM
Routes of administrationBy mouth
ATC codeN07BC03 ( WHO )
Legal statusAU : S8 (Controlled drug) CA : Schedule I DE : Anlage III (Special prescription form required) US : Schedule II
Protein binding~80%
MetabolismCYP3A4
Elimination half-life2.6 days
CAS Number1477-40-3 43033-72-3 ( hydrochloride )
PubChem CID15130
IUPHAR/BPS7212
DrugBank15130
ChemSpider14401
UNIIR3B637Y991
KEGGD04716
ChEMBLChEMBL1514
CompTox Dashboard ( EPA )DTXSID3023211
FormulaC 23 H 31 N O 2
Molar mass353.498 gmol 1
3D model ( JSmol )Interactive image

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Indications

In randomized comparison of levacetylmethadol three doses per week and daily methadone maintenance therapy for 26 weeks in 315 patients, those taking levacetylmethadol were less likely to test positive for opioid use, both during treatment and at 26 weeks. There were no adverse events, cardiological or otherwise. In a randomized, crossover trial, 62 patients stable on methadone received levacetylmethadol on alternate days and daily methadone for 3 months each, followed by a further 6 months during which they were free to choose between two drugs. Levacetylmethadol maintenance was associated with a lower rate of heroin use than methadone maintenance. Most of subjects prefer levacetylmethadol rather than methadone. Their main reasons were that it produced less withdrawal, fewer adverse effects and less craving for heroin, and entailed fewer pick-up days.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Opiates

Active Substance: levacetylmethadol Common Name: levacetylmethadol ATC Code: N02AC Marketing Authorisation Holder: Sipaco Internacional Lda. Active Substance: levacetylmethadol Status: Withdrawn Authorisation Date: 1997-07-01 Therapeutic Area: Opioid-Related Disorders Pharmacotherapeutic Group: Analgesics ORLAAM is indicated for substitution maintenance treatment of opiate addiction in adults previously treated with methadone, as part of a comprehensive treatment plan including medical, social and psychological care. ORLAAM should be administered under supervision of physicians with experience in addiction treatment and whenever practicable, in centres specialising in treatment of drug addiction. Marketing Authorisation for ORLAAM has been withdrawn at the request of the Marketing Authorisation Holder. Always consult your healthcare provider to ensure information displayed on this page applies to your personal circumstances.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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