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Levallorphan

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Last Updated: 23 November 2020

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General | Latest Info

Levallorphan

Chemical and physical data
3D model ( JSmol )Interactive image
FormulaC 19 H 25 N O
Molar mass283.415 gmol 1
Clinical data
AHFS / Drugs.comInternational Drug Names
ATC codenone
Routes of administrationOral
Identifiers
CAS Number152-02-3 Y
ChEMBLChEMBL1254682 N
ChemSpider4514267 Y
CompTox Dashboard ( EPA )DTXSID9023205
DrugBankDB00504 N
ECHA InfoCard100.005.273
IUPHAR/BPS7209
PubChem CID5359371
UNII353613BU4U
Legal status
Legal statusIn general: (Prescription only)

The most significant side effect of parenterally administering opioid agonists is their ability to produce respiratory depression by diminishing the responsiveness of brain respiratory centers to arterial carbon dioxide. Thus, patients ' breathing rate decrease. Opioid antagonists have been available since 1951. Although these agents reverse opioid-induced respiratory depression, when administered to patients with non-opioid-induced respiratory depression, both nalorphine and levallorphan were able to produce their own respiratory depression and to enhance barbiturate-induced respiratory depression. Naloxone became available in the late 1960s and today remains the only opioid antagonist free of any agonistic properties. Naloxone also reverses other properties of opioids, namely analgesia and sedation. 110 This action is not entirely innocuous; if opioids are administered for postsurgical analgesia, naloxone administration antagonize this effect, leaving patient with unmanaged postsurgical pain. Naloxone may be administered endotracheally in situations in which IV access is not available. Administer via IV route or endotracheally, improved respiratory function is noted within 2 minutes. Nalbuphine, opioid agonist-antagonist, has been used successfully to reverse respiratory depression induced by opioid agonists. 111 Because nalbuphine has its own agonist properties, it provides excellent reversal of opioid-induced respiratory depression but does not entirely remove postsurgical analgesia or sedation because of its own analgesia-inducing properties.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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