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Levemir The Same As Lantus

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Last Updated: 29 November 2020

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General | Latest Info

Over the past several years, use of GLP-1 drugs together with basal Insulins as treatment for type 2 diabetes has been a hot topic among healthcare providers. For several reasons, this combination therapy makes a lot of sense: 1 weight loss provided by GLP-1 agonists can help reduce or overcome weight gain associated with long-acting Insulin therapy; and 2 GLP-1 agonists and basal Insulins help improve blood glucose control in complementary ways. Basal Insulins act over long periods of time at a constant rate to cover background between meal Insulin needs. Meanwhile, GLP-1 agonists cause Insulin secretion only when blood glucose levels are high, effectively lowering post-meal blood glucose spikes without increasing the risk for hypoglycemia. Last year, study examining Byetta in combination with LANTUS confirmed much of this thinking, as people with type 2 diabetes achieved greater reductions in A1c and experienced weight loss instead of weight gain with both therapies versus LANTUS alone. Although use of mealtime Insulin such as APIDRA, Humalog, or NovoLog with basal Insulin attempts to accomplish the same exact goal, mealtime Insulins typically cause weight gain and significantly higher rates of hypoglycemia because their action is not dependent on blood glucose levels. We were excite, then, to hear that two GLP-1 agonist and basal Insulin therapy regimens were recently approved for use by people with type 2 diabetes. In the US, Byetta is now approved for use alongside LANTUS, and in Europe, Victoza is approved for use with Levemir. Although we had learnt through conversations with diaTribe advisory board that off-label use of GLP-1 agonists with basal Insulins was quite common before these approvals were grant, we believe that Byetta and Victoza could become even more attractive alternatives to mealtime Insulins as reimbursement improve combination had been rarely covered by insurance companies in past and healthcare provider familiarity with this combination use expand. There are also a number of other exciting GLP-1 agonist / basal Insulin combination products in development, some of which may only be given in one shot per day!. For more information on these products as well as more detailed account on use of GLP-1 agonists with basal Insulins, please see New Now Next column in diaTribe issue 29.-BK

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Side effects

Serious side effects from Lantus are common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think youre having a medical emergency. Serious side effects and their symptoms can include the following: hypokalemia. Symptoms can include: weakness fatigue, muscle cramping, abnormal heart rhythm paralysis, respiratory failure, Severe Hypoglycemia. * Allergic reaction.


What is Lantus?

Lantus is available only as brand-name medication. It doesnt currently have a generic form. Generic Drug is exact copy of the active drug in brand-name medication. Although there isnt generic form of Lantus, follow-on insulin glargine product called Basaglar is available. Follow-on insulins are biologic products that are highly similar to original brand-name Drug. However, follow-ons arent consider true generic drugs. This is because the way biologic drugs are made is very complex and ca create true copies of the original drug. Basaglar is made with the same type of insulin as Lantus, so it follow-on to Lantus. The Food and Drug Administration considers follow-on drugs to be just as safe and effective as the original brand-name version.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Study Design

Open-label, parallel-group, noninferiority trial of 582 Insulin-naive patients with type 2 diabetes. Patients were randomized 1: 1 to receive Lantus or Insulin detemir once daily as add-on therapy to Oral glucose-lowering drugs. Both insulins were titrate to FPG target of 108 mg / dL. Additional morning Insulin dose of Insulin detemir was allowed if pre-dinner PG was > 126 mg / dL, but only if pre-breakfast PG was < 126 mg / dL or nocturnal hypoglycemia precluded achievement of the FPG target. Participants were eligible for A1C range from 7. 5 % to 10 %. The primary endpoint was change in A1C at the end of the treatment period.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Levemir Vs Lantus Insulin

Levemir is a brand-name prescription medication. It is used to lower blood sugar levels in: adults and children aged 2 years old and older with type 1 diabetes adults with type 2 diabetes. Levemir has not been studied in children younger than 2 years of age with type 1 diabetes. It also hasnt been studied in any children younger than 18 years of age with type 2 diabetes. Levemir contains the drug insulin detemir, which is long-acting insulin. Levemir is given a subcutaneous injection. Youll give yourself injections either once or twice a day based on your doctor or pharmacist's direction. Levemir comes as a solution. The solution is available in two forms: vial and prefilled pen. Vial contains 10 milliliters of drug solution, with 100 units of insulin detemir per mL. It is used with a needle for injection. Needles are sold separately and may require prescription in certain states. The pen is called FlexTouch pen. Each pen contains 3 mL of drug solution, with 100 units of insulin detemir per mL.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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