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Xyzal Allergy 24HR is now available as an over - counter treatment for symptoms associated with seasonal and year - round allergies. Symptoms include runny nose, itchy or watery eyes, sneezing, and itching in the nose or throat. Until the Food and Drug Administration's approval in February 2017, Xyzal was available only as a prescription drug. Xyzal Allergy 24HR is recommended for use in patients aged 6 years. Childrens Xyzal Allergy 24HR oral solution is recommended for use in patients aged 2 years. Xyzal, antihistamine, works via selective inhibition of H1 receptors. Antihistaminic activity of levocetirizine has been documented in a variety of animal and human models. Xyzal Allergy 24HR is available as 5mg strength tablets in 10 -, 35 -, 55 -, and 80 - count bottles. Childrens Xyzal Allergy 24HR is available as 2. 5mg / 5mL strength oral solution in tutti frutti flavor. For more information, call 633 - 1610 or visit Xyzal.
H 1 antihistamines act as inverse agonists that combine with and stabilize inactive conformation of H 1 receptor, shifting equilibrium toward an inactive state. H 1 receptor polymorphisms have been describe, although it is not yet clear how they influence clinical response to H 1 antihistamines. Human H 1 receptors have approximately 45% homology with muscarinic receptors. H 1 antihistamines down - regulate allergic inflammation through H 1 receptor, either directly or indirectly through nuclear factor - B, ubiquitous transcription factor, through which they down - regulate antigen presentation, expression of proinflammatory cytokines and cell adhesion molecules, and chemotaxis. In addition, through their effects on calcium ion channel activity, H 1 antihistamines decrease mediator release; however, this effect is only seen at high H 1 - antihistamine concentrations. Traditionally, H 1 antihistamines have been classified into 6 chemical groups: alkylamines, ethanolamines, ethylenediamines, phenothiazines, piperazines, and piperidines. Currently, most commonly used classification system is the functional one, in which H 1 antihistamines are classified as either first - generation medications that readily cross the bloodbrain barrier and potentially sedate and impair cognitive and psychomotor function, or second - generation drugs that cross the blood - brain barrier to minimal extent and are relatively nonsedating and nonimpairing. H 1 antihistamines, formerly know as H 1 receptor antagonists or H 1 receptor blockers, are among the most commonly used medications in the world, not only for prevention and treatment of symptoms of allergic rhinitis, allergic conjunctivitis, and urticaria, in which there is good evidence for their efficacy, but also for variety of other allergic and nonallergic diseases, in which there is No satisfactory evidence for their efficacy. More than 40 H 1 antihistamines are available worldwide. Health care professionals and consumers generally assume that all H 1 antihistamines approved for use are proven to be efficacious and safe. This is an incorrect assumption with regard to first - generation medications in this class, most of which were introduced decades before clinical pharmacology studies and randomized controlled trials of medication efficacy and safety were required by regulatory agencies. In contrast, second - generation H 1 antihistamines, particularly cetirizine, desloratadine, fexofenadine, levocetirizine, and loratadine, have been systematically and thoroughly investigated in clinical pharmacology studies and in randomized placebo - control trials in allergic rhinoconjunctivitis and chronic urticaria. In this review, we compare clinical pharmacology, efficacy, and safety of first - generation H 1 antihistamines with those of second - generation H 1 antihistamines.
Levocetirizine is an over - counter antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes / nose, sneezing, hives, and itching. It works by blocking certain natural substances that your body makes during allergic reaction. Levocetirizine is available under the following different brand names: Xyzal Allergy 24HR Tablets, Xyzal Allergy 24HR Oral Solution, and Xyzal. 5 mg 2. 5 mg / 5 mL indicates for relief of symptoms associated with seasonal and perennial allergic rhinitis. 5 mg orally daily in the evening. Some patients may respond to 2. 5 mg / day indicated for relief of symptoms associated with seasonal and perennial allergic rhinitis. Infants under 6 months: Safety and efficacy are not established Infants over 6 months to children 5 years: 1. 25 mg orally each day in evening children 6 - 12 years: 2. 5 mg orally each day in evening Children over 12 years: 5 mg orally each day in evening; Some patients may respond to 2. 5 mg / day indicates for uncomplicated skin manifestations of chronic idiopathic hives. 5 mg orally daily in the evening indicates uncomplicated skin manifestations of chronic idiopathic hives. Infants under 6 months: Safety and efficacy are not established Infants over 6 months to children 5 years: 1. 25 mg orally each day in evening children 6 - 12 years: 2. 5 mg orally each day in the evening Children over 12 years: 5 mg orally each day in evening Creatinine Clearance 50 - 80 mL / min: 2. 5 mg orally each day Creatinine Clearance 30 - 50 mL / min: 2. 5 mg orally every other day Creatinine Clearance 10 - 30 mL / min: 2. 5 mg orally 2 times / week Creatinine Clearance less than 10 mL / min and or hemodialysis: contraindicate Creatinine Clearance 50 - 80 mL / min: 2. 5 mg orally each day Creatinine Clearance l 30 - 50 mL / min: 2. 5 mg orally every other day Creatinine Clearance 10 - 30 mL / min: 2. 5 mg orally 2 times / week Creatinine Clearance less than 10 mL / min and or hemodialysis: contraindicate any degree of renal impairment: contraindicate adult and Pediatric: No dose adjustment required
Cns depression: May cause CNS depression, which may impair physical or mental abilities; Patients must be careful about performing tasks which require mental alertness. Renal impairment: Levocetirizine is used primarily in kidneys; use with caution in adults with mild to severe renal impairment; dosage adjustments may be needed. Use is contraindicated in end - stage renal disease, patients undergoing hemodialysis, and in infants and children 6 months to 11 years of age with renal impairment. Urinary retention: Urinary retention may occur; use with caution in patients with increased risk of Urinary retention; discontinue if Urinary retention occurs.
Levocetirizine is rapidly and extensively absorbed following oral administration. In adults, peak plasma concentrations are achieved 0. 9 hours after administration of oral tablet. Accumulation ratio following daily oral administration is 1. 12 with steady state achieved after 2 days. Peak concentrations are typically 270 ng / mL and 308 ng / mL following single and repeat 5 mg once daily dose, respectively. Food had no effect on the extent of exposure to levocetirizine tablet, but Tmax was delayed by about 1. 25 hours and Cmax was decreased by about 36% after administration with high fat meal; therefore, levocetirizine can be administered with or without food. The dose of 5 mg of XYZAL oral solution is bioequivalent to 5 mg dose of XYZAL tablets. Following oral administration of 5 mg dose of XYZAL oral solution to healthy adult subjects, mean peak plasma concentrations were achieved approximately 0. 5 hours post dose.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use and share it with your doctor and pharmacist. Do not start, stop, or change dosage of any medicines without your doctor's approval. Tell your doctor or pharmacist if you are taking other products that cause drowsiness, such as opioid pain or cough relievers, alcohol, marijuana, drugs for sleep or anxiety, muscle relaxants, or other antihistamines. Check labels on all your medicines because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Do not use any other antihistamines applied to the skin because increased side effects may occur. Levocetirizine is very similar to hydroxyzine and cetirizine. Do not use these medications while using levocetirizine. This medication may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.
The typical dosage is one 5 - mg tablet once per day in the evening. The typical dosage is one half - tablet once per day in the evening. Dosage for levocetirizine oral tablet hasnt been established for children younger than 6 years of age. The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more drugs stay in your body for longer time. This raises your risk of side effects. Your doctor may start you on a lower dose or different dosing schedule. This can help keep levels of this drug from building up too much in your body.
In addition to adverse reactions reported during clinical trials and listed above, following adverse reactions have also been identified during postapproval use of XYZAL. Because these reactions are reported voluntarily from population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Cardiac disorders: palpitations, tachycardia Ear and labyrinth disorders: vertigo Eye disorders: blur vision, visual disturbances Gastrointestinal disorders: nausea, vomiting General disorders and administration site conditions: edema Hepatobiliary disorders: hepatitis Immune system disorders: anaphylaxis and hypersensitivity Metabolism and nutrition disorders: increased appetite Musculoskeletal, connective tissues, and bone disorders: arthralgia, myalgia Nervous system disorders: dizziness, dysgeusia, febrile seizure, movement disorders, paresthesia, seizure, tremor Psychiatric disorders: aggression and agitation, depression, hallucinations, insomnia, nightmare, suicidal ideation Renal and urinary disorders: dysuria, urinary retention Respiratory, thoracic, and mediastinal disorders: dyspnea Skin and subcutaneous tissue disorders: angioedema, fix drug eruption, pruritus, rash and urticaria besides these reactions report under treatment with XYZAL, other potentially severe adverse events have been report from postmarketing experience with cetirizine. Since levocetirizine is the principal pharmacologically active component of cetirizine, one should take into account the fact that following adverse events could also potentially occur under treatment with XYZAL. Cardiac disorders: severe hypotension Gastrointestinal disorders: cholestasis Nervous system disorders: extrapyramidal symptoms, myoclonus, orofacial dyskinesia, tic Pregnancy, puerperium and perinatal conditions: stillbirth Renal and urinary disorders: glomerulonephritis Skin and subcutaneous tissue disorders: acute generalize exanthematous pustulosis; rebound pruritus - pruritus within few days after discontinuation of cetirizine, usually after long - term use of cetirizine.
In deciding to use medicine, risks of taking medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, following should be consider: tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non - prescription products, read the label or package ingredients carefully. Appropriate studies performed to date have not demonstrated pediatric - specific problems that would limit the usefulness of levocetirizine in children. Safety and efficacy have not been established in infants younger than 6 months of age for levocetirizine oral solution, children younger than 2 years of age for Children's Xyzal Allergy 24HR oral solution, and children younger than 6 years of age for tablet.S Use is not recommended in children 6 months to 11 years of age with kidney disease. Appropriate studies performed to date have not demonstrated geriatric - specific problems that would limit the usefulness of levocetirizine in the elderly. However, elderly patients are more likely to have age - related liver, kidney, or heart problems, which may require caution and adjustment in dose for patients receiving levocetirizine. There are no adequate studies in women to determine infant risk when using this medication during breastfeeding. Weigh potential benefits against potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. Following interactions have been selected on the basis of their potential significance and are not necessarily all - inclusive. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both medicines. Pitolisant certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional about use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: enlarged prostate or lesions in the spinal cordUse. With caution. May increase the risk of urinary retention. Kidney disease, severe or patients undergoing hemodialysisShould not be used in patients with these conditions. Urinary retention use with caution. May make this condition worse.
Get emergency medical help if you have signs of allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using levocetirizine and call your doctor at once if you have: worsening allergy or urticaria symptoms; painful or difficult urination; little or no urination; light - head feeling, like you might pass out; fever; or signs of ear infection - ear pain or full feeling, trouble hearing, drainage from your ear, fussiness in child. Drowsiness, tiredness; sinus pain; ear infection; cough; fever; nosebleed; vomiting, diarrhea, constipation; dry mouth; or weight gain. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 - 800 - FDA - 1088.
Levocetirizine is also know as: Levrix, Xyzal, Xyzal Allergy 24HR medically reviewed by drugs. Com. It was last updated on Apr 15 2020. This drug should be used during pregnancy only if clearly needed US FDA pregnancy category: B Animal studies have failed to reveal evidence of fetal harm and teratogenicity. There is no controlled data on human pregnancy. US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate risk to fetus and there are no adequate and well - controlled studies in pregnant women. Caution is recommend. Excrete into human milk: Unknown excrete into animal milk: Data not available Comments: - Cetirizine, racemic form of this drug, has been reported to be excreted into human breast milk and thus it is expected that levocetirizine may be excreted in breast milk. - Larger doses or prolonged use of this drug may cause drowsiness and other effects in nursing infants or possibly decrease milk supply, particularly if used in combination with sympathomimetic or before lactation is well establish. Always consult your healthcare provider to ensure information displayed on this page applies to your personal circumstances.
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