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Levothyroxine 75 Mcg

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Last Updated: 14 October 2020

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General | Latest Info

Wherever you obtain your prescriptions, always double check your pills when you receive them to be sure that you are getting what your doctor prescribed. Do this for all of your prescriptions, not just Levothyroxine. Levothyroxine is the pharmaceutical name for a synthetic thyroid hormone prescribed for people who have been treated for Thyroid Cancer. Several brand - name synthetic Levothyroxine preparations are currently available. These include Levothroid, Levoxyl, Synthroid, Tirosint and Unithroid in the United States; and Eltroxin and Euthyrox in Canada. Although all these medications are synthetic Levothyroxine, they are not identical. Manufacturing processes differ, as do fillers and dyes. These differences may affect absorption of drugs. Absorption affects how much of drug your body actually receive. For this reason, Thyroid Cancer specialist physicians recommend that Thyroid Cancer patients consistently take Levothyroxine from the same manufacturer. If you need to change manufacturers for some reason, you should have your thyroid levels checked 6 - 8 weeks later, because your TSH may have changed and no longer be at the level recommended by your physician. Thyroid Cancer patients should be very careful when having their prescription fill, because some pharmacies and some health insurance plans allow switching from the brand that patient was taking to generic. Generic prescription means pharmacist could potentially fill prescription with one manufacturer Levothyroxine one month and use another manufacturer next month. Because of absorption differences, change in manufacturers can result in change in your TSH level. Always know which manufacturer you are using. Make sure that your prescription specifies the brand name or word Levothyroxine followed by the name of manufacturer. Also, make sure that your prescription is marked Dispense as written or do not substitute. This extra effort by you and your physician will make it clear to the pharmacist or pharmacy technician exactly what you need. If you encounter a pharmacy technician or pharmacist who insists that you can change manufacturers, tell them that because of your Thyroid Cancer, you need to stay on same brand as part of your Thyroid Cancer management and that Thyroid Cancer specialist physicians recommend against brand switching due to the effect on TSH and resulting need for additional blood testing. Thyca and its medical advisors do not recommend any particular brand in preference to other brands. Representatives of endocrinology associations and ThyCa have spoken and written to the US Food and Drug Administration in past years, noting this point and also discussing therapeutic equivalence and brand switching. Also, check prices and co - payments. Prices vary among pharmacies and sometimes the cost of pills is lower than co - payment. Another point to remember is that Levothyroxine is temperature - sensitive, especially if above room temperature. Mailing during the heat of summer may result in lowered potency. Ordering a three - month supply at the beginning of summer can lessen that risk. Picking up pills at the local pharmacy also helps avoid temperature extremes. Store your Levothyroxine away from heat, humidity, and light.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Uses

Levothyroxine is used to treat underactive thyroid. It replaces or provides more thyroid hormone, which are normally produced by thyroid gland. Low thyroid hormone levels can occur naturally or when the thyroid gland is injured by radiation / medications or removed by surgery. Having enough thyroid hormone is important for maintaining normal mental and physical activity. In children, having enough thyroid hormones is important for normal mental and physical development. This medication is also used to treat other types of thyroid disorders. This medication should not be used to treat infertility unless it is caused by low thyroid hormone levels.


What is levothyroxine?

Many other medicines can affect your thyroid hormone levels. Certain other medicines may also increase or decrease the effects of levothyroxine. Certain medicines can make this medicine less effective if taken at the same time. If you use any of the following drugs, avoid taking them within 4 hours before or 4 hours after you take levothyroxine: Calcium carbonate; cholestyramine, colesevelam, colestipol; ferrous sulfate iron supplement; sucralfate; sodium polystyrene sulfonate; stomach acid reducers - esomeprazole, lansoprazole, omeprazole, rabeprazole, Nexium, Prilosec, Prevacid, Protonix, Zegerid, and others; or antacids that contain aluminum or magnesium - Gaviscon, Maalox, Milk of Magnesia, Mintox, Mylanta, Pepcid Complete, and others. Many drugs can interact with levothyroxine. This includes prescription and over - counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Side Effects

Adverse reactions associated with levothyroxine therapy are primarily those of hyperthyroidism due to therapeutic overdosage. They include the following: general: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating; central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia; cardiac: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest; pseudotumor cerebri and slip capital femoral epiphysis have been report in children receiving levothyroxine therapy. Overtreatment may result in craniosynostosis in infants and premature closure of epiphyses in children with resultant compromise adult height. Seizures have been reported rarely with institution of levothyroxine therapy. Inadequate levothyroxine dosage will produce or fail to ameliorate signs and symptoms of hypothyroidism. Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone products. These include urticaria, pruritus, skin rash, flushing, angioedema, various GI symptoms, fever, arthralgia, serum sickness and wheezing. Hypersensitivity to levothyroxine itself is not known to occur. In addition to the above events, following has been report, predominately when Levoxyl tablets were not taken with water: choking, gagging, tablet stuck in throat and dysphagia. Read entire FDA prescribing INFORMATION for Levoxyl


4. How and when to take levothyroxine

You may need to take several different tablets to make up your dose. Levothyroxine comes in 25 microgram, 50 microgram and 100 microgram tablets. The word microgram is sometimes written with Greek symbols followed by letter g. Microgram is 1 000 times smaller than a milligram. Your doctor will tell you how many tablets to take each day. Although starting doses are usually the same, dose of levothyroxine you end up taking, or how quickly the dose increase, depends on your symptoms, hormone levels, age and whether you have any other health problems. Adults usually start with a dose of between 50 micrograms and 100 micrograms once day. This may increase gradually over a few weeks to between 100 micrograms and 200 micrograms once a day. Some people, such as over - 50s or people with heart disease, may start on lower dose. If you are taking levothyroxine as liquid, 5mls has 25 micrograms, 50 micrograms or 100 micrograms in it.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

What is levothyroxine?

Taking levothyroxine with certain drugs may result in an increase in adverse effects. Examples of these drugs include: antidepressants such as amitriptyline and maprotiline. Side effects of both of these antidepressants and levothyroxine may increase when you take these drugs together. This may put you at risk for irregular heart rhythms. Sympathomimetic Drugs such as pseudoephedrine and albuterol. The effects of both sympathomimetic drugs and levothyroxine may increase when you take these drugs together. This may put you at risk of serious heart problems. Blood thinners such as warfarin. Taking these drugs with levothyroxine may increase your risk of bleeding. Your doctor may need to decrease the dosage of your blood thinner if you also taking levothyroxine. Ketamine. Taking this drug with levothyroxine may increase your risk of high blood pressure and fast heart rate.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Warnings

Thyroid hormones, either alone or with other therapeutic agents, should not be used for treatment of obesity or for weight loss. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction; larger doses may produce serious or even life - threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects. This medication contains Levothyroxine. Do not take Synthroid, Levoxyl, L Thyroxine, Levo T, Levothroid, Levothyroxine T4, Levoxine, Tirosint, or Unithroid If you are allergic to Levothyroxine or any ingredients contained in this drug. Keep out of reach of children. In case of overdose, get medical help or contact the Poison Control Center immediately.


SIDE EFFECTS

Get emergency medical help if you have signs of allergic reaction to levothyroxine: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Fast or irregular heartbeats; chest pain, pain spreading to your jaw or shoulder; shortness of breath; fever, hot flashes, sweating; tremors, or if you feel unusually cold; weakness, tiredness, sleep problems; memory problems, feeling depressed or irritable; headache, leg cramps, muscle aches; feeling nervous or irritable; dryness of your skin or hair, hair loss; irregular menstrual periods; or vomiting, diarrhea, appetite changes, weight changes. Certain side effects may be more likely in older adults. Chest pain, irregular heartbeats; shortness of breath; tremors, muscle pain or weakness; headache, leg cramps; feeling nervous or irritable, trouble sleeping; increased appetite; feeling hot; weight loss; changes in your menstrual periods; diarrhea; or skin rash, partial hair loss. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 - 800 - FDA - 1088.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Take as directed

Thyroid Hormones, including Levothyroxine Sodium Tablets, either alone or with other therapeutic agents, should not be used for treatment of obesity or for weight loss. In Euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects. Hypothyroidism Levothyroxine Sodium Tablets are indicated as Replacement therapy in primary, secondary and Tertiary congenital or acquired Hypothyroidism. Levothyroxine Sodium Tablets are indicated as adjunct to surgery and radioiodine therapy in management of thyrotropin - dependent Well - differentiate Thyroid Cancer. Limitations of Use: Levothyroxine Sodium Tablets are not indicated for suppression of benign Thyroid nodules and nontoxic diffuse goiter in iodine - sufficient patients as there are no clinical benefits and overtreatment with Levothyroxine Sodium Tablets may induce hyperthyroidism. Levothyroxine Sodium Tablets are not indicated for treatment of Hypothyroidism during the recovery phase of subacute thyroiditis. Take Levothyroxine Sodium Tablets with a full glass of water as Tablet may rapidly disintegrate. Administer Levothyroxine Sodium Tablets as single Daily Dose, on an empty stomach, one - half to one hour before breakfast. Administer Levothyroxine Sodium Tablets at least 4 hours before or after drugs known to interfere with Levothyroxine Sodium Tablet absorption. Evaluate the need for dose adjustments when regularly administering within one hour of certain foods that may affect Levothyroxine Sodium Tablets absorption. Administer Levothyroxine Sodium Tablets to infants and children who cannot swallow intact tablets by crushing tablet, suspending freshly crushed tablet in small amount of water and immediately administering suspension by spoon or dropper. Do not store suspension. Do not administer in foods that decrease absorption of Levothyroxine Sodium Tablets, such as soybean - base infant formula. The Dose of Levothyroxine Sodium Tablets for Hypothyroidism or pituitary TSH Suppression depends on a variety of factors including: patient's AGE, Body Weight, Cardiovascular status, Concomitant medical conditions, Concomitant medications, co - administer food and specific nature of the condition being treat. Dosing must be individualized to account for these factors and dose adjustments are made based on periodic assessment of patient's clinical response and laboratory parameters. The peak therapeutic effect of giving dose of Levothyroxine Sodium Tablets may not be attained for 4 to 6 weeks. Primary Hypothyroidism in Adults and in Adolescents in Whom Growth and Puberty are Complete start Levothyroxine Sodium Tablets at full Replacement Dose in otherwise healthy, non - elderly individuals who have been hypothyroid for only a short time. The Average full Replacement Dose of Levothyroxine Sodium Tablets is approximately 1. 6 mcg Per Kg Per day. Adjust Dose by 12. 5 to 25 mcg increments every 4 to 6 weeks until the patient is clinically Euthyroid and serum TSH returns to normal. Doses greater than 200 mcg per day are seldom require. Inadequate response to daily doses of greater than 300 mcg per day is rare and may indicate poor compliance, malabsorption, drug interactions or a combination of these factors.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

USE

Levothyroxine is used to treat underactive thyroid gland. It replaces or provides more thyroid hormone, which are normally produced by thyroid gland. Low thyroid hormone levels can occur naturally or when the thyroid gland is injured by radiation / medications or removed by surgery. Having enough thyroid hormones is important for normal mental and physical activity. In children, having enough thyroid hormones is important for normal mental and physical development. This medication is also used to treat other types of thyroid disorders. This medication should not be used to treat infertility unless it is caused by low thyroid hormone levels. Read Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start taking levothyroxine and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually once daily on an empty stomach, 30 minutes to 1 hour before breakfast. This medication may be taken by first mixing it in water, or it may be taken directly. To take it by mixing in water, open ampule as direct. Then turn the ampule upside down and slowly squeeze the soft part of the ampule to empty contents into glass or cup of water. Release pressure and wait a few seconds. Repeat squeezing and releasing the ampule at least 5 times, until no more liquid comes out of the ampule. Stir solution and drink all of the liquid right away. Rinse a glass or cup with more water and drink to make sure you have taken all the medicine. Do not prepare supplies ahead of time. To take this medication directly, slowly squeeze soft part of open ampule to empty contents into mouth or onto a spoon. Release pressure and wait a few seconds. Repeat squeezing and releasing the ampule at least 5 times, until no more liquid comes out of the ampule. Take all of the liquid right away. Dosage is based on your age, weight, medical condition, and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, take it at same time each day. Do not stop taking this medication without consulting your doctor. Thyroid replacement treatment is usually taken for life. There are different brands of levothyroxine available. Do not change brands without first consulting your doctor or pharmacist. Certain medications can decrease the amount of thyroid hormone that is absorbed by your body. If you are taking any of these drugs, separate them from this medication for at least 4 hours. Symptoms of low thyroid hormone levels include tiredness, muscle aches, constipation, dry skin, weight gain, slow heartbeat, or sensitivity to cold. Tell your doctor if your condition is not getting better or if it gets worse after several weeks of taking this medication.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Drug Class: Thyroid products

Levothyroxine should not be used to treat obesity or weight problems. Dangerous side effects or death can occur from misuse of levothyroxine, especially if you are taking any other weight - loss medications or appetite suppressants. Since thyroid hormones occur naturally in the body, almost anyone can take levothyroxine. However, you may not be able to take this medicine if you have certain medical conditions. Tell your doctor if you have: untreated or uncontrolled adrenal gland disorder; thyroid disorder called thyrotoxicosis; or symptoms of heart attack. To make sure levothyroxine is safe for you, tell your doctor if you have ever had: thyroid nodule; heart disease, blood clot, or blood - clotting disorder; diabetes; kidney disease; anemia; osteoporosis, or low bone mineral density; problems with your pituitary gland; or any food or drug allergies. Tell your doctor if you have recently received radiation therapy with iodine. If you become pregnant while taking levothyroxine, do not stop taking medicine without your doctor's advice. Having low thyroid hormone levels during pregnancy could harm both mother and baby. Your dose needs may be different during pregnancy. Tell your doctor if you are breast - feeding. Your dose needs may be different while you are nursing. Do not give this medicine to child without medical advice. Tirosint is not approved for use by anyone younger than 6 years old.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Symptoms of Hypothyroidism

Take Levothyroxine once day in the morning, ideally at least 30 minutes before having breakfast or drink containing caffeine, like tea or coffee. Food and caffeinated drinks can both stop your body from taking in Levothyroxine properly, so it does not work as well. If you stop taking Levothyroxine your symptoms are likely to come back. You may need to take several different tablets to make up your dose. Levothyroxine comes in 25 microgram, 50 microgram and 100 microgram tablets. The word microgram is sometimes written with Greek symbols followed by letter g. Microgram is 1 000 times smaller than a milligram. Your doctor will tell you how many tablets to take each day. Although starting doses are usually the same, dose of Levothyroxine you end up taking, or how quickly the dose increase, depends on your symptoms, hormone levels, age and whether you have any other health problems. Adults usually start with a dose of between 50 micrograms and 100 micrograms once day. This may increase gradually over a few weeks to between 100 micrograms and 200 micrograms once a day. Some people, such as over - 50s or people with heart disease, may start on lower dose. If you are taking Levothyroxine as liquid, 5mls has 25 micrograms, 50 micrograms or 100 micrograms in it. Levothyroxine is available as a liquid for children and people who find it difficult to swallow tablets. If you or your child are taking Levothyroxine as a liquid, it will usually be made up for you by a pharmacist. It will come with a plastic syringe or spoon to help you measure the right dose. If you do not have a syringe or measuring spoon, ask your pharmacist for one. Do not use kitchen teaspoon as it will not give the right amount. If you forget to take a dose, take it as soon as you remember, unless it's almost time for your next dose. In which case, just skip forget dose. Do not take 2 doses together to make up for missed dose. If you often forget often dose, it may help to set alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine. Taking an extra dose of Levothyroxine by accident is unlikely to harm you. If you accidentally take more than 1 extra dose, you get side effects such as racing heart beat or chest pain - these may not happen straight away, it can be several days before they come on. Your doctor will do regular blood tests to check levels of thyroid hormones in your body before and after starting Levothyroxine. These will allow your doctor to adjust the dose to suit you. At the start of treatment, you can expect to have blood tests often. Once your hormone levels are stable, you 'll usually have a blood test after 4 to 6 months, and after that once a year.


SIDE EFFECTS

Applies to levothyroxine: oral capsule liquid fill, oral solution, oral tablet along with its needed effects, levothyroxine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur, they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking levothyroxine: chest pain or discomfort decreases urine output, difficult or labored breathing difficulty with swallowing, dilate neck veins, extreme fatigue, fainting fast, slow, irregular, pounding, or racing heartbeat or pulse fever, heat intolerance, hives or welts, skin itching, rash, or redness irregular breathing irritability menstrual changes nausea pain or discomfort in arms, jaw, back, or neck sweating swelling of eyes, face, lips, throat, or tongue tightness in chest tremors blur or double vision dizziness eye pain lack or slowing of normal growth in children limp or walk favoring one leg pain in hip or knee seizures severe headache get emergency help immediately if any of following symptoms of overdose occur while taking levothyroxine: change in consciousness cold, clammy skin confusion disorientation fast or weak pulse lightheadedness loss of consciousness sudden headache sudden loss of coordination sudden slurring of speech some side effects of levothyroxine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: abdominal or stomach cramps, change in appetite, crying diarrhea, false or unusual sense of well - being, fear or nervousness, feeling not well or unhappy feeling of discomfort feeling of warmth feeling things are not real feelings of suspicion and distrust hair loss headache increase appetite mental depression muscle weakness quick to react or overreact emotionally rapidly changing moods redness of face, neck, arms, and occasionally, upper chest restlessness trouble getting pregnant trouble sitting still unusual tiredness or weakness vomiting weight gain or loss

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Mild Hypothyroidism

The first study to look at long - term incidence of overt hypothyroidism was the Whickham survey, which found that rise of serum TSH above 2 mIU / l was associated with increased risk of hypothyroidism, which increased further if anti - TPO antibodies were positive. The survey found that twofold rise in serum TSH would increase probability from 1 to 4% and this risk further increase to 38% if positive for anti - TPO antibodies. Similarly, another recent study showed that the rate of progression to overt hypothyroidism was more in patients having TSH > 10 mIU / l but, for those who had TSH between 4. 5 and 10. 0 mIU / l, rate was higher in those who were anti - TPO antibodies positive. The Resolution of SCH at end of 2 years was higher in those with TSH of 4. 5 - 6. 9 mIU / l compared with those with high TSH levels. In another study, both male and female patients aged > 55 years were followed for up to 72 months and it was found that TSH level normalized in 52% of those patients who had serum TSH between 5. 0 and 9. 9 mIU / l. However, increase in TSH levels with advancing age and upper limit of TSH reference range are still controversial and under debate. Most patients with mild - SCH are asymptomatic and only a few of them have typical hypothyroid symptoms. A large questionnaire - based study on 25 862 patients shows significant difference, although small, in symptoms between euthyroid and SCH patients. The most frequent symptoms reported were problems with memory, slowness of thinking, muscle cramps, muscle weakness, tiredness, dry skin, feeling colder, hoarseness of voice, puffy eyes and more constipation. Jorde and colleagues found that there was no difference in symptoms of hypothyroidism between SCH patients having TSH < 10 mIU / l compared with healthy controls except for tiredness. A recent review looked at current evidence and found no significant difference in symptoms in patients with SCH and euthyroid controls. Randomize trials which look at the effect of levothyroxine therapy in patients having mild - SCH are considered insufficient to support levothyroxine treatment in this group and benefits seen in available trials are either very minor or of no benefit. One of studies which compared beneficial effects of levothyroxine treatment in SCH patients having TSH between 5. 0 and 10. 0 mIU / l with placebo found no benefit. Similarly, many other recent studies have not shown any improvement in symptoms such as anxiety, mood and cognition in elderly patients. However, there is also some evidence of benefits regarding symptom improvement with levothyroxine treatment in patients having TSH < 10 mIU / l. In summary, most patients with mild - SCH have either very few symptoms or no symptoms and there is some evidence, albeit insufficient, of improvement in tiredness by levothyroxine treatment. It is well known that thyroid hormones act on the heart and vasculature. Research has been conducted recently to determine the effects of SCH on the cardiovascular system.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Subclinical Hypothyroidism

Hypothyroidism is defined as failure of the Thyroid gland to produce sufficient Thyroid hormone to meet the metabolic demands of the body. Untreated hypothyroidism can contribute to hypertension, dyslipidemia, infertility, cognitive impairment, and neuromuscular dysfunction. Data derived from the National Health and Nutrition Examination Survey suggests that about one in 300 people in the United States has hypothyroidism. 1 prevalence increases with age, and is higher in females than in males. 2 It is estimated that nearly 13 million Americans have undiagnosed hypothyroidism. 3 hypothyroidism may occur as a result of primary gland failure or insufficient Thyroid gland stimulation by the hypothalamus or pituitary gland. Primary gland failure can result from congenital abnormalities, autoimmune destruction, iodine deficiency, and infiltrative diseases. Autoimmune Thyroid disease is the most common etiology of hypothyroidism in the United States. 4 Iatrogenic forms of hypothyroidism occur after thyroid surgery, radioiodine therapy, and neck irradiation. 5 Disorders generally associated with transient hypothyroidism include postpartum thyroiditis, subacute thyroiditis, silent thyroiditis, and thyroiditis associated with Thyroid - stimulating hormone receptor - blocking antibodies. 5 central causes of hypothyroidism typically present with other manifestations of hypothalamic or pituitary dysfunction, and are characterized by inappropriately normal or low levels of TSH relative to insufficient Thyroid hormone. Drugs classically associated with Thyroid dysfunction include lithium, amiodarone, interferon alfa, interleukin - 2, and tyrosine kinase inhibitors. 6 7 hypothyroidism is a clinical disorder commonly encountered by primary care physician. Untreated hypothyroidism can contribute to hypertension, dyslipidemia, infertility, cognitive impairment, and neuromuscular dysfunction. Data derived from the National Health and Nutrition Examination Survey suggests that about one in 300 people in the United States has hypothyroidism. Prevalence increases with age, and is higher in females than in males. Hypothyroidism may occur as a result of primary gland failure or insufficient Thyroid gland stimulation by the hypothalamus or pituitary gland. Autoimmune Thyroid disease is the most common etiology of hypothyroidism in the United States. Clinical symptoms of hypothyroidism are nonspecific and may be subtle, especially in older people. The best laboratory assessment of thyroid function is the serum Thyroid - stimulating hormone test. There is no evidence that screening asymptomatic adults improves outcomes. In the majority of patients, alleviation of symptoms can be accomplished through oral administration of synthetic levothyroxine, and most patients will require lifelong therapy. Combination triiodothyronine / thyroxine therapy has no advantages over thyroxine monotherapy and is not recommend. Among patients with subclinical hypothyroidism, those at greater risk of progressing to clinical disease, and who may be considered for therapy, include patients with Thyroid - stimulating hormone levels greater than 10 mIU per L and those who have elevated Thyroid peroxidase antibody titers.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Dosing Considerations

Avoid under - treatment or over - treatment with this drug. This may result in adverse effects. Initiate lower dose of medicine in the elderly, those with angina pectoris, cardiovascular disease, or in those with severe hypothyroidism. Long - term therapy decreases bone mineral density; use lowest dose in postmenopausal women and women using suppressive doses. Lower dose of Tirosint capsules may be required compared with standard T4 tablets for hypothyroidism in patients with impaired gastric acid secretion to reach their target TSH levels; Tirosint has shown improved absorption compared with conventional T4 tablets. Check for bioequivalence if switching brands / generics, or every week after switching from one levothyroxine sodium preparation to another.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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