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Levothyroxine 88 Mcg Tablet

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Last Updated: 29 November 2020

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General | Latest Info

Levothyroxine is used to treat underactive thyroid. It replaces or provides more thyroid hormone, which are normally produced by thyroid gland. Low thyroid hormone levels can occur naturally or when the thyroid gland is injured by radiation / medications or removed by surgery. Having enough thyroid hormone is important for maintaining normal mental and physical activity. In children, having enough thyroid hormones is important for normal mental and physical development. This medication is also used to treat other types of thyroid disorders. This medication should not be used to treat infertility unless it is caused by low thyroid hormone levels. Read Patient Information Leaflet if available from your pharmacist before you start taking levothyroxine and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually once daily on an empty stomach, 30 minutes to 1 hour before breakfast. Take this medication with a full glass of water unless your doctor directs you otherwise. If you are taking capsule form of this medication, swallow it whole. Do not split, crush, or chew. People who cannot swallow capsule whole should use tablet form of medication. For infants or children who cannot swallow whole tablets, crush the tablet and mix in 1 to 2 teaspoons of water, and give using a spoon or dropper right away. Do not prepare supply in advance or mix tablets in soy infant formula. Consult your pharmacist for more information. Dosage is based on your age, weight, medical condition, laboratory test results, and response to treatment. Use this medication regularly in order to get most benefit from it. To help you remember, take it at same time each day. Do not stop taking this medication without first consulting with your doctor. Thyroid replacement treatment usually takes for life. There are different brands of levothyroxine available. Do not change brands without first consulting your doctor or pharmacist. Certain medications can decrease the amount of thyroid hormone that is absorbed by your body. If you are taking any of these drugs, separate them from this medication by at least 4 hours. Symptoms of low thyroid hormone levels include tiredness, muscle aches, constipation, dry skin, weight gain, slow heartbeat, or sensitivity to cold. Tell your doctor if your condition worsens or persists after several weeks of taking this medication. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use and share it with your doctor and pharmacist. Do not start, stop, or change dosage of any medicines without your doctor's approval. Blood thinners digoxin sucroferric oxyhydroxide If you miss dose, take it as soon as you remember. If it is near time of next dose, skip miss dose. Take your next dose at regular time.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Uses

Levothyroxine is used to treat underactive Thyroid. It replaces or provides more Thyroid hormone, which is normally produced by Thyroid gland. Low Thyroid Hormone levels can occur naturally or when the Thyroid gland is injured by radiation / medications or removed by surgery. Having enough Thyroid Hormone is important for maintaining normal mental and physical activity. In children, having enough Thyroid Hormone is important for normal mental and physical development. This medication is also used to treat other types of Thyroid disorders. This medication should not be used to treat infertility unless it is caused by low Thyroid Hormone levels.


SIDE EFFECTS

Get emergency medical help if you have signs of allergic reaction to levothyroxine: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Fast or irregular heartbeats; chest pain, pain spreading to your jaw or shoulder; shortness of breath; fever, hot flashes, sweating; tremors, or if you feel unusually cold; weakness, tiredness, sleep problems; memory problems, feeling depressed or irritable; headache, leg cramps, muscle aches; feeling nervous or irritable; dryness of your skin or hair, hair loss; irregular menstrual periods; or vomiting, diarrhea, appetite changes, weight changes. Certain side effects may be more likely in older adults. Chest pain, irregular heartbeats; shortness of breath; tremors, muscle pain or weakness; headache, leg cramps; feeling nervous or irritable, trouble sleeping; increased appetite; feeling hot; weight loss; changes in your menstrual periods; diarrhea; or skin rash, partial hair loss. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What is levothyroxine?

Many other medicines can be affected by your thyroid hormone levels. Certain other medicines may also increase or decrease the effects of levothyroxine. Certain medicines can make this medicine less effective if taken at the same time. If you use any of the following drugs, avoid taking them within 4 hours before or 4 hours after you take levothyroxine: Calcium carbonate; cholestyramine, colesevelam, colestipol; ferrous sulfate iron supplement; sucralfate; sodium polystyrene sulfonate; stomach acid reducers-esomeprazole, lansoprazole, omeprazole, rabeprazole, Nexium, Prilosec, Prevacid, Protonix, Zegerid, and others; or antacids that contain aluminum or magnesium-Gaviscon, Maalox, Milk of Magnesia, Mintox, Mylanta, Pepcid Complete, and others. Many drugs can interact with levothyroxine. This includes prescription and over-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Side Effects

If you will be taking this medicine for a long time, it is very important that your doctor check the progress of you or your child at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood tests will be needed to check for unwanted effects. Levothyroxine should not be used for treatment of obesity or for the purpose of losing weight. This medicine is not effective for weight reduction. If take in large amounts, levothyroxine may cause serious unwanted effects. Hypothyroidism can sometimes cause infertility in men and women. Levothyroxine should not be used for treatment of infertility unless it is caused by hypothyroidism. For patients with Diabetes: It is very important that you keep track of your blood or urine sugar levels as instructed by your doctor. Check with your doctor right away if you notice any changes in your sugar levels. If you think you have become pregnant while using this medicine, tell your doctor right away. You may need a larger dose of levothyroxine while you are pregnant. Women who are post-menopausal or who use this medicine for a long time may have some bone loss, which could lead to Osteoporosis. Talk with your doctor if you have questions or concerns about this. Call your doctor right away if you or your child start to have rapid or irregular heartbeats, chest pain, leg cramps, headaches, nervousness, irritability, sleeplessness, tremors, change in appetite, weight gain or loss, vomiting, diarrhea, excessive sweating, heat intolerance, fever, changes in menstrual periods, hives, or skin rash. These could be symptoms of too much medicine in your body. Do not suddenly stop taking this medicine without first checking with your doctor. Your doctor may want you or your child to gradually reduce the amount you are using before stopping completely. Make sure any doctor or dentist who treats you knows that you or your child are using this medicine. You or your child may need to stop using this medicine several days before having surgery or medical tests. Temporary loss of hair may occur during the first few months of levothyroxine therapy. Ask your doctor about this if you have any concerns. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription-medicines and herbal or vitamin supplements.


Proper Use

This medicine will need to be taken for the rest of your life or your child's life. Do not stop taking this medicine or change your dose without first checking with your doctor. It may take several weeks before you start to notice that your symptoms are better. It is best to take this medicine on an empty stomach. Take it with a full glass of water at least 30 minutes to 1 hour before eating breakfast. Swallow capsule whole. Do not cut or crush it. Also, if you are taking multiple strengths of this medicine, remove capsules from blisters in advance to help you identify the strength of each capsule. For infants and children who cannot swallow tablet form, tablets can be crushed and mixed with small amount of water. You may use a spoon or dropper to give mixture. Use mixture right away and do not store it to use later. This medicine should come with patient instructions. Read and follow instructions carefully. Ask your doctor if you have any questions. This medicine may be mixed with water or be given directly into the mouth. If mixed with water, squeeze the contents of 1 single unit-dose ampule into a glass or cup containing water. Stir and drink it immediately. Add some water to a glass or cup and drink water. This will help get all of the medicine out of a glass or cup. Do not mix this medicine with any other liquid except water. Do not store mixture for later use. If take without water, squeeze medicine directly into mouth or into a spoon and swallow it immediately. This medicine should be take at least 4 hours before or 4 hours after these medicines: antacids, calcium supplements, stomach medicines, cholestyramine, colesevelam, colestipol, iron supplements, Kayexalate, orlistat, simethicone, and sucralfate. Cotton seed meal, dietary fiber, soybean flour, or walnuts may affect absorption of this medicine from your body. You may have to take this medicine at different time of day from when you eat these foods. Talk with your doctor more about this if you have concerns. Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Interactions

If you will be taking this medicine for a long time, it is very important that your doctor check the progress of you or your child at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood tests will be needed to check for unwanted effects. Levothyroxine should not be used for treatment of obesity or for the purpose of losing weight. This medicine is not effective for weight reduction. If taken in large amounts, Levothyroxine may cause serious unwanted effects. Hypothyroidism can sometimes cause infertility in men and women. Levothyroxine should not be used for treatment of infertility unless it is caused by Hypothyroidism. For Patients with Diabetes: It is very important that you keep track of your blood or urine sugar levels as instructed by your doctor. Check with your doctor right away if you notice any changes in your sugar levels. If you think you have become pregnant while using this medicine, tell your doctor right away. You may need a larger dose of Levothyroxine while you are pregnant. Women who are post-menopausal or who use this medicine for a long time may have some bone loss, which could lead to Osteoporosis. Talk with your doctor if you have questions or concerns about this. Call your doctor right away if you or your child start to have rapid or irregular heartbeats, chest pain, leg cramps, headaches, nervousness, irritability, sleeplessness, tremors, change in appetite, weight gain or loss, vomiting, diarrhea, excessive sweating, heat intolerance, fever, changes in menstrual periods, hives, or skin rash. These could be symptoms of too much medicine in your body. Do not suddenly stop taking this medicine without first checking with your doctor. Your doctor may want you or your child to gradually reduce the amount you are using before stopping completely. Make sure any doctor or dentist who treats you knows that you or your child are using this medicine. You or your child may need to stop using this medicine several days before having surgery or medical tests. Temporary loss of hair may occur during the first few months of Levothyroxine therapy. Ask your doctor about this if you have any concerns. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription-medicines and herbal or vitamin supplements. Over-treatment with Levothyroxine may cause an increase in heart rate, cardiac wall thickness, and cardiac contractility and may precipitate angina or arrhythmias, particularly in patients with cardiovascular disease and in elderly patients. Initiate THYRO-TABS therapy in this population at lower doses than those recommended in younger individuals or in patients without cardiac disease. Monitor for cardiac arrhythmias during surgical procedures in Patients with coronary artery disease receiving suppressive THYRO-TABS therapy. Monitor Patients receiving concomitant THYROTABS and sympathomimetic agents for signs and symptoms of coronary insufficiency. If cardiac symptoms develop or worsen, reduce THYRO-TABS dose or withhold for one week and restart at a lower dose.


Side Effects

Adverse reactions associated with THYRO-TABS therapy are primarily those of hyperthyroidism due to therapeutic overdosage. They include the following: general: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia Musculoskeletal: tremors, muscle weakness, muscle spasm Cardiovascular: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest Respiratory: dyspnea Gastrointestinal: diarrhea, vomiting, abdominal cramps, elevations in liver function tests Dermatologic: hair loss, flushing, rash Endocrine: decrease bone mineral density Reproductive: menstrual irregularities, impaired fertility seizures have been report rarely with institution of levothyroxine therapy.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

What is levothyroxine?

Taking levothyroxine with certain drugs may result in an increase in adverse effects. Examples of these drugs include: antidepressants such As amitriptyline and maprotiline. Side effects of both of these antidepressants and levothyroxine may increase when you take these drugs together. This may put you at risk of irregular heart rhythms. Sympathomimetic Drugs such as pseudoephedrine and albuterol. The effects of both sympathomimetic Drugs and levothyroxine may increase when you take these drugs together. This may put you at risk of serious heart problems. Blood thinners such as warfarin. Taking these drugs with levothyroxine may increase your risk of bleeding. Your doctor may need to decrease the dosage of your blood thinner if youre also taking levothyroxine. Ketamine. Taking this drug with levothyroxine may increase your risk of high blood pressure and fast heart rate.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Warnings

For people with heart problems: Levothyroxine can increase your risk of serious heart problems, such as heart attack, abnormal heart rhythm, and heart failure. This risk is increased if youve already had these problems. Tell your doctor if you have heart problems or a history of heart problems. Your doctor may decide to start you on lower dosage of Levothyroxine. For people with Diabetes: Let your doctor know if you have Diabetes. Taking Levothyroxine can make your Diabetes worse. Your doctor may monitor your blood sugar level more closely while you take this drug and adjust your Diabetes drugs if needed For people with Osteoporosis: Using Levothyroxine for a long time can cause decreases in your bone mineral density and put you at higher risk of bone fractures. For people with adrenal or Pituitary gland problems: Let your doctor know if you have any adrenal or Pituitary gland problems. Using Levothyroxine can cause changes to your levels of thyroid hormone that could make these problems worse. For people with blood clotting disorders: Let your doctor know if you have any blood clotting disorders. Taking Levothyroxine may make it more difficult for your blood to clot and make bleeding more likely.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Take as directed

Levothyroxine oral tablet is used for long-term treatment. It comes with serious risks if you do take it as prescribe. If you stop taking drug or do take it at all: Your Thyroid Hormones will remain low, which may result in low energy levels, tiredness, weakness, slower speech, constipation, or thicken skin. It may even lead to coma. If you miss doses or do take drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, certain amount needs to be in your body at all times. If You Take too much: You could have dangerous levels of drugs in your body. Symptoms of overdose can include: confusion, disorientation, stroke shock coma. If you think youve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away. What to do if you miss Dose: Take your Dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects. How to tell if a drug is working: You should feel your symptoms of low Thyroid Hormone Decrease. For instance, you should have more energy, less tiredness, and less weakness.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

USE

Take LEVO-T with a full glass of water as the tablet may rapidly disintegrate. Administer LEVO-T as a single Daily Dose, on an empty stomach, one-half to one hour before breakfast. Administer LEVO-T at least 4 hours before or after Drugs know to interfere with LEVO-T Absorption. Evaluate the need for dose adjustments when regularly administering within one hour of certain foods that may affect LEVO-T Absorption. Administer LEVO-T to infants and children who cannot swallow intact tablets by crushing the tablet, suspending freshly crushed tablet in a small amount of water and immediately administering suspension by spoon or dropper. Do not store suspension. Do not administer foods that decrease absorption of LEVO-T, such as soybean-base infant formula. The dose of LEVO-T for Hypothyroidism or pituitary TSH suppression depends on a variety of factors including: patient AGE, Body Weight, Cardiovascular status, concomitant medical conditions, concomitant medications, co-administer food and specific nature of the condition being treat. Dosing must be individualized to account for these factors and dose adjustments made based on periodic assessment of Patients ' clinical response and Laboratory Parameters. The Peak therapeutic Effect of giving dose of LEVO-T may not be attain for 4 to 6 weeks. Start LEVO-T at full replacement Dose in otherwise healthy, non-elderly individuals who have been hypothyroid for only a short time. The average full replacement dose of LEVO-T is approximately 1. 6 mcg Per Kg Per day. Adjust Dose by 12. 5 to 25 mcg increments every 4 to 6 weeks until the patient is clinically Euthyroid and serum TSH returns to normal. Doses greater than 200 mcg per day are seldom require. Inadequate response to daily doses of greater than 300 mcg per day is rare and may indicate poor compliance, malabsorption, drug interactions, or a combination of these factors. For elderly patients or patients with underlying cardiac disease, start with Dose of 12. 5 to 25 mcg per day. Increase dose every 6 to 8 weeks, as needed, until the patient is clinically Euthyroid and serum TSH returns to normal. The full replacement dose of LEVO-T may be less than 1 mcg per Kg per day in elderly patients. In Patients with severe longstanding Hypothyroidism, start with a dose of 12. 5 to 25 mcg per day. Adjust Dose in 12. 5 to 25 mcg increments every 2 to 4 weeks until the patient is clinically Euthyroid and serum TSH level is normalize. Start LEVO-T at full replacement dose in otherwise healthy, non-elderly individuals. Start with lower dose in elderly patients, patients with underlying Cardiovascular disease or patients with severe longstanding Hypothyroidism as described above. Serum TSH is not a reliable measure of LEVO-T Dose adequacy in Patients with secondary or tertiary Hypothyroidism and should not be used to monitor therapy. Use serum Free-T4 level to monitor adequacy of therapy in this patient population.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

INDICATION 2

Medically reviewed by Drugs. Com. Last updated on Jul 20 2020. Dosing should be individualized with consideration give to age, cardiovascular status, concomitant medical conditions, and specific nature of condition; follow clinical response and laboratory Parameters Closely As DOSE is Adjust: INITIAL DOSES: Primary Hypothyroidism: Healthy Individuals who have been Hypothyroid FOR Short Time INITIAL DOSE: 1. 6 mcg / kg orally once day-Adjust DOSE to 12. 5 to 25 mcg increments every 4 to 6 weeks until clinically Euthyroid and TSH returns to normal individuals over 50 years and / or Patients with Cardiovascular Disease: INITIAL DOSE: 12. 5 to 25 mcg orally once day-Adjust DOSE at 6 to 8-weeks intervals until clinically Euthyroid and TSH returns to normal Severe Longstanding Hypothyroidism: INITIAL DOSE: 12. 5 to 25 mcg orally once day-Adjust DOSE to increments OF 12. 5 to 25 mcg / day every 2 to 4 weeks until clinically Euthyroid and TSH returns to normal MAINTENANCE DOSE: Approximately 1. 6 mcg / kg / day is Full replacement DOSE MAXIMUM DOSE: 200 to 300 mcg / day Secondary or Tertiary Hypothyroidism:-Dosing As described above except serum Free-T4 level will be used to Monitor therapy; serum TSH levels are not reliable Measure and should not be use-Titrate until clinically Euthyroid and serum Free-T4 levels are restore to upper half OF normal range Comments:-DOSE should be individualize with regular monitoring OF clinical status and laboratory Parameters.-Peak Effect OF give DOSE May not be attain FOR 4 to 6 weeks.-NOT indicate FOR TREATMENT OF Hypothyroidism during recovery phase OF subacute thyroiditis.-Co-administer food and concomitant medications May significantly affect Absorption; Take on empty stomach and at least 4 hours before or after Drugs know to interfere with Levothyroxine Absorption. Use: As replacement therapy in Primary, Secondary, and Tertiary Congenital or acquire Hypothyroidism TSH levels should generally be suppressed to below 0. 1 IU / L-DOSE greater than 2 mcg / kg orally once day is usually required to achieve this degree OF suppression Comments:-Patients with high-Risk tumors may target greater level OF TSH suppression, however, this is not well define.-This Drug is not indicated FOR suppression OF benign Thyroid nodules and nontoxic diffuse goiter in iodine-sufficient Patients As there are no clinical benefits and overtreatment May induce hyperthyroidism. Use: As adjunct to surgery and radioiodine therapy in management OF thyrotropin-dependent well-differentiate Thyroid cancer. Parenteral Formulation:-INITIAL loading DOSE: 300 to 500 mcg IV once-MAINTENANCE DOSE: 50 to 100 mcg IV once day until patient can tolerate Oral therapy Comment:-Age, General physical condition, Cardiac Risk factors, severity and duration OF myxedema Coma should be considered when determining INITIAL and MAINTENANCE dosages.-Relative bioavailability between Oral and IV Levothyroxine is estimate to be 48 % to 74 %; due to individual differences, TSH levels should be Measure and DOSES Adjust accordingly. Use: FOR TREATMENT OF myxedema Coma.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Clinical Pharmacology

Table

HormoneRatio in ThyroglobulinBiologic Potencyt 1/2 (days)Protein Binding (%) a
Levothyroxine (T4)10 - 2016-7 b99.96
Liothyronine (T3)14299.5

Absorption of orally administered T4 from gastrointestinal tract ranges from 40 % to 80 %. The majority of SYNTHROID dose is absorbed from the jejunum and upper ileum. Relative bioavailability of SYNTHROID Tablets, compared to equal nominal dose of oral Levothyroxine Sodium solution, is approximately 93 %. T4 Absorption is increased by fasting, and decrease in malabsorption syndromes and by certain foods such as soybeans. Dietary fiber decreases bioavailability of T4. Absorption may also decrease with age. In addition, many drugs and foods affect T4 Absorption. Circulating Thyroid hormones are greater than 99 % bound to plasma proteins, including thyroxine-binding globulin, thyroxine-binding prealbumin, and albumin, whose capacities and affinities vary for each hormone. The higher affinity of both TBG and TBPA for T4 partially explains higher serum levels, slower metabolic clearance, and longer half-life of T4 compared to T3. Protein-bound Thyroid hormones exist in reverse equilibrium with small amounts of free hormone. Only unbound hormone is metabolically active. Many drugs and physiologic conditions affect the binding of Thyroid hormones to serum proteins. Thyroid hormones do not readily cross the placental barrier. T4 is slowly eliminate. The major pathway of thyroid hormone metabolism is through sequential deiodination. Approximately 80 % of Circulating T3 is derived from peripheral T4 by monodeiodination. The liver is a major site of degradation for both T4 and T3, with T4 deiodination also occurring at a number of additional sites, including kidney and other tissues. Approximately 80 % of the daily dose of T4 is deiodinated to yield equal amounts of T3 and reverse T3. T3 and rT3 are further deiodinated to diiodothyronine. Thyroid hormones are also metabolize via conjugation with glucuronides and sulfates and excrete directly into bile and gut where they undergo enterohepatic recirculation. Thyroid hormones are primarily eliminated by the kidneys. Portion of conjugated hormone reach colon unchanged and is eliminated in feces. Approximately 20 % of T4 is eliminated in stool. Urinary excretion of T4 decreases with age.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Contraindications

If you will be taking this medicine for a long time, it is very important that your doctor check the progress of you or your child at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood tests will be needed to check for unwanted effects. Levothyroxine should not be used for treatment of obesity or for the purpose of losing weight. This medicine is not effective for weight reduction. If taken in large amounts, Levothyroxine may cause serious unwanted effects. Hypothyroidism can sometimes cause infertility in men and women. Levothyroxine should not be used for treatment of infertility unless it is caused by hypothyroidism. For Patients with Diabetes: It is very important that you keep track of your blood or urine sugar levels as instructed by your doctor. Check with your doctor right away if you notice any changes in your sugar levels. If you think you have become pregnant while using this medicine, tell your doctor right away. You may need a larger dose of Levothyroxine while you are pregnant. Women who are post-menopausal or who use this medicine for a long time may have some bone loss, which could lead to Osteoporosis. Talk with your doctor if you have questions or concerns about this. Call your doctor right away if you or your child start to have rapid or irregular heartbeats, chest pain, leg cramps, headaches, nervousness, irritability, sleeplessness, tremors, change in appetite, weight gain or loss, vomiting, diarrhea, excessive sweating, heat intolerance, fever, changes in menstrual periods, hives, or skin rash. These could be symptoms of too much medicine in your body. Do not suddenly stop taking this medicine without first checking with your doctor. Your doctor may want you or your child to gradually reduce the amount you are using before stopping completely. Make sure any doctor or dentist who treats you knows that you or your child are using this medicine. You or your child may need to stop using this medicine several days before having surgery or medical tests. Temporary loss of hair may occur during the first few months of Levothyroxine therapy. Ask your doctor about this if you have any concerns. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription-medicines and herbal or vitamin supplements. Over-treatment with Levothyroxine may cause an increase in heart rate, cardiac wall thickness, and cardiac contractility and may precipitate angina or arrhythmias, particularly in patients with cardiovascular disease and in elderly patients. Initiate LEVO-T therapy in this population at lower doses than those recommended in younger individuals or in patients without cardiac disease. Monitor for cardiac arrhythmias during surgical procedures in patients with coronary artery disease receiving suppressive LEVO-T therapy. Monitor Patients receiving concomitant LEVOT and sympathomimetic agents for signs and symptoms of coronary insufficiency. If cardiac symptoms develop or worsen, reduce the LEVO-T dose or withhold for one week and restart at a lower dose.


Side Effects

Adverse reactions associated with LEVO-T therapy are primarily those of hyperthyroidism due to therapeutic overdosage. They include the following: general: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia Musculoskeletal: tremors, muscle weakness, muscle spasm Cardiovascular: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest Respiratory: dyspnea Gastrointestinal: diarrhea, vomiting, abdominal cramps, elevations in liver function tests Dermatologic: hair loss, flushing, rash Endocrine: decrease bone mineral density Reproductive: menstrual irregularities, impaired fertility seizures have been report rarely with institution of levothyroxine therapy.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Dosing Considerations

Avoid under-treatment or over-treatment with this drug. This may result in adverse effects. Initiate lower dose of medicine in the elderly, those with angina pectoris, cardiovascular disease, or in those with severe hypothyroidism. Long-term therapy decreases bone mineral density; use lowest dose in postmenopausal women and women using suppressive doses. Lower dose of Tirosint capsules may be required compared with standard T4 tablets for hypothyroidism in patients with impaired gastric acid secretion to reach their target TSH levels; Tirosint has shown improved absorption compared with conventional T4 tablets. Check for bioequivalence if switching brands / generics, or every week after switching from one levothyroxine sodium preparation to another.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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