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Levothyroxine And Antacids

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Last Updated: 15 October 2020

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Using Calcium carbonate together with levothyroxine may decrease the effects of levothyroxine. You should separate administration of levothyroxine and Calcium carbonate by at least 4 hours. If your doctor does prescribes these medications together, you may need dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. The timing of meals relative to your levothyroxine dose can affect absorption of medication. Therefore, levothyroxine should be taken on a consistent schedule with regard to time of day and relation to meals to avoid large fluctuations in blood levels, which may alter its effects. In addition, absorption of levothyroxine may be decreased by foods such as soybean flour, cotton seed meal, walnuts, dietary fiber, Calcium, and Calcium fortified juices. These foods should be avoided within several hours of dosing if possible. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. When levothyroxine is given during continuous enteral nutrition for more than 7 days, tube feeding should be interrupted for at least one hour before and one hour after dose of levothyroxine. You may need more frequent blood tests to monitor levothyroxine levels. Calcium absorption may be increased by taking it with food. However, foods high in oxalic acid, or phytic acid may decrease Calcium absorption. Calcium may be taken with food to increase absorption. Consider spacing Calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Introduction

S everal studies have shown that certain medications can cause malabsorption of levothyroxine sodium when they are coadministered. These medications include bile acid - binding resins, iron salts, sucralfate, aluminum - containing antacids, raloxifene, chromium picolinate, sevelamer HCl, colesevelam HCl, and lanthanum carbonate. The mechanism by which this malabsorption occurs is presumed to be binding of medication to thyroid hormone, forming an insoluble or nonabsorbable complex. Calcium carbonate, which is commonly used for prevention and treatment of osteoporosis, has also been shown to reduce levothyroxine sodium absorption. However, other commonly used calcium supplements, including calcium citrate and calcium acetate, have not been prospectively study. As the population ages, increasing numbers of patients are taking either calcium carbonate or calcium citrate to prevent or treat osteoporosis. Additionally, many patients with advanced renal disease are treated with calcium acetate to lower serum phosphate. It is therefore important to determine if malabsorption of levothyroxine occurs with concurrent use of either of these calcium preparations. To evaluate these potential interactions with thyroid hormone, we conducted single - dose absorption studies of levothyroxine in normal volunteers, with and without simultaneous administration of these agents.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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