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Levothyroxine Generic

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Last Updated: 28 September 2020

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General | Latest Info

Home PATIENTS Portal Thyroid Q & Q and: Thyroxine Preparations Most Endocrinologists believe that FDA methods FOR testing equivalence OF Thyroxine Preparations ARE seriously flaw. One OF problems with FDA methods is that they do not use TSH blood tests, cornerstone OF Thyroxine monitoring, to compare different Thyroxine preparations in STUDY participants. Another concern is many factors that can influence thyroxine absorption and availability to your body. There is variation in thyroxine content among various approved preparations with same state dose on tablet, in some cases greater than 10%. This is a potential problem if patients switch to Thyroxine Preparations. Thyroid disease often requires lifelong therapy and is best managed with consistent and precise treatment with the same brand OF Thyroid hormone. Your doctor may change your dose of Thyroid hormone, but the brand of your Thyroid hormone medication should be constant. When you go to the pharmacy, do not change the brand of your thyroid medication without checking with your doctor. You should not change from one brand of Thyroid medication to another, from your brand OF Thyroid medication to a GENERIC product, or from one GENERIC product to another without first checking with your doctor. Your insurance company or state aid program, however, may not pay FOR cost OF brand name drug or charge higher co - payment if you want a specific brand name drug. Repeat blood tests and visits to your doctor may be required if your Thyroxine preparation is change, and your dose may need to be readjust. Finally, be familiar with the shape and markings on your branded Levothyroxine product. Generic Levothyroxine products may contain brand name as part of labeling, so be sure to inspect your tablets when you receive refill. Take a look at our Patient Web Brochure HYPOTHYROIDISM To learn more about HYPOTHYROIDISM and how it is treat. Medical Disclaimer information contained in or made AVAILABLE through the American Thyroid Association Website is not intended to replace services of trained health professionals or to be a substitute for medical advice OF physicians. A user should consult a physician on all matters relating to his or her health, and particularly in respect to any symptoms that may require diagnosis or medical attention. The American Thyroid Association makes no representations or warranties with respect to any information offered or provided within or through the American Thyroid Association Website regarding treatment, action, or application of medication. Terms OF Use Privacy Policy

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

It's Equally Safe

Generic levothyroxine is just as safe as brand namesin United States, These include Synthroid, Levoxyl, Unithroid, and Tirosintbecause it has the same FDA - approve active ingredient. That say, some people are sensitive to fillers and additives found in inactive ingredients of levothyroxine, such as gluten, dyes, and lactose. If you re not sure what your prescription's ingredients contain, ask your pharmacist for a list. The study that was presented at the 2017 American Thyroid Association conference looked at almost 88 000 new hypothyroid patients who had just started treatment with either generic or brand - name levothyroxine. Researchers want to look at risk for hospitalization from cardiovascular problems, which are more likely both in hypothyroidism and in people taking levothyroxine. Another notable point is that the majority of patients, nearly 71%, were prescribed generic levothyroxine, while just over 22% were prescribed brand names. Researchers also found that over 60% of prescribers were primary care physicians, most of whom prescribed generics, while nearly 11% were endocrinologists who were significantly more likely to prescribe brand - name levothyroxine.


SIDE EFFECTS

Adverse reactions associated with levothyroxine therapy are primarily those of hyperthyroidism due to therapeutic overdosage. They include the following: general: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating; central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia; cardiac: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest; pseudotumor cerebri and slip capital femoral epiphysis have been report in children receiving levothyroxine therapy. Overtreatment may result in craniosynostosis in infants and premature closure of epiphyses in children with resultant compromise adult height. Seizures have been reported rarely with institution of levothyroxine therapy. Inadequate levothyroxine dosage will produce or fail to ameliorate signs and symptoms of hypothyroidism. Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone products. These include urticaria, pruritus, skin rash, flushing, angioedema, various GI symptoms, fever, arthralgia, serum sickness and wheezing. Hypersensitivity to levothyroxine itself is not known to occur. In addition to the above events, following has been report, predominately when Levoxyl tablets were not taken with water: choking, gagging, tablet stuck in throat and dysphagia.


What is Synthroid?

Brand - name Synthroid contains the active drug levothyroxine. And levothyroxine is also available as a generic drug. A Generic drug is an exact copy of active drug in brand - name medication. Generics is considered to be as safe and effective as the original drug. Even though Synthroid and levothyroxine have the same active ingredient, drugs may not be exactly identical. And switching between two drugs may cause large changes in your thyroid hormone levels. Because of this, your doctor may need to monitor you if you switch from one drug to another. It is best to stick with either brand - name medication or generic medication. But if you must switch between these versions, talk with your doctor. Theyll probably recommend that you have certain blood tests 4 to 6 weeks after making the switch. This allows your doctor to be sure that your thyroid hormone levels are within normal range.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Potencies May Differ

The key concern about generic Levothyroxine, and valid complaints by doctors, is that every time you get a refill, you can potentially get Levothyroxine made by a different generic manufacturer. Here's why this can be a problem. Levothyroxine is required by law to fall within 5% of its stated potency and the US Food and Drug Administration requires that this potency fall within 95% to 105%. Each company's formula for particular dosage of Levothyroxine tends to be consistent, so if drugmaker A's product is usually 96%, it will typically consistently run at about 96% potency. Similarly, if drugmaker B's Levothyroxine at particular dosage typically runs at 105% of potency, that will usually be consistent. So, using the example of 100 mcg Levothyroxine tablet, drugmaker A's 100 mcg tablet delivers 96 mcg of active Levothyroxine. Drugmaker B's delivers 105 mcg of active Levothyroxine. Going from drugmaker to B's product would be a difference of around 65 mcg per week, which is almost like taking an extra pill each week. Conversely, if you go from B to, it's like eliminating more than half a pill each week.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Levothyroxine Preparations

This issue of JCEM provides the US with new clinical data on L - thyroxine equivalence. Studies seem to reach opposite conclusions, but understanding of regulatory history shows the US that they assess different aspects of question. Before T 4 was comprehensively regulated by the Food and Drug Administration, Hansen asserted that 2 leading name brand preparations of LT4 were equivalent. Within 5 years, no less than 10 studies assessed the bioequivalence of these 2 products using various methods and concluded that they either were or were not equivalent. In 1997, due to concerns with product potency and variability, FDA declared LT4 preparations to be new drugs and required that all existing and future LT4 products be approved through the new Drug application process in order to remain on the US market. This establishes uniform expectations for drug performance and results in significant improvement in LT4 products available for clinical use. Nda products were unique formulations and were not considered interchangeable. This remained the case until the abbreviated NDA process of measuring relative bioavailability of LT4 products was implemented to provide a mechanism for assessing potential interchangeability of generic and reference name brand LT4 preparations. Shortcomings of traditional pharmacokinetic method result in modification of process to correct for endogenous T 4, but concerns remain about potentially clinically significant differences in LT4 dose of 12. 5% or more might not be recognized with pharmacokinetic approach in products designated as Bioequivalent by pharmacokinetic standard. Therapeutic equivalence codes are assigned once products meet bioequivalence specifications. Designation of AB was assigned if the standard for bioequivalence was meet, or products were rat as BX if this standard was not meet. Current therapeutic equivalence ratings are summarized in Table 1. Theoretical insensitivity of pharmacokinetics was confirmed when the reference drug, Synthroid, was compared to the generic candidate. Generic was recognized as therapeutically equivalent, given AB2 designation, and was advertise as interchangeable but the new generic was 12. 5% more bioavailables than referenced brand. Expert clinicians express great concern, and one of the studies in this issue of JCEM directly assesses this same comparison. Further LT4 Product improvement has occurred with the imposition of narrower potency requirement by FDA to minimize variability of same LT4 Product ingested from refill to refill. To meet the new goal of 95 - 105% of labeled content, some products have been reformulate. In both cases of reformulation, FDA has been showing data documenting that new formulations are therapeutically equivalent with older versions of same preparations by pharmacokinetic analysis, but previous therapeutic equivalence ratings have not been reassess. So now to new work that advances our understanding of bioequivalence, therapeutic equivalence, and potential interchangeability of LT4 products.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Special Considerations

Despite this, there are some individuals for whom generic Levothyroxine may not be advise. In particular: those who have had thyroid cancer: Fluctuating TSH, which can occur from inconsistent thyroid hormone replacement, can affect the body's ability to prevent cancer from returning. Discuss treatment options with your doctor. Those with certain allergies, digestive conditions, or who have DRUG absorption issues: in these cases, Tirosint softgel option that only contains Levothyroxine, gelatin, glycerin, and watermay be specifically recommend. It's important to note, however, that this DRUG is costly and not widely prescribe. It may not be covered by your insurance company at all or without explanation of need from your doctor. If these situations don't apply to you and you decide that changing to generic is the way to go for cost - saving reasons, be sure to speak with your doctor about the recommended schedule for checking your TSH levels. Getting several - month supply: When you fill prescription written to last you for several months, you 'll ensure that you are taking medication with the same potency and ingredients for that duration. Talk to Your pharmacist: Once you learn that you re stable on a particular generic, ask the pharmacist if it's possible to get refills from that same manufacturer. This may not always be possible, but it is worth ask.


Interactions

Many drugs affect thyroid hormone pharmacokinetics and metabolism and may alter therapeutic response to SYNTHROID. In addition, thyroid hormones and thyroid status have varying effects on pharmacokinetics and actions of other drugs. A Listing of drug - thyroidal axis interactions is contained in Table 2. The list of drug - thyroidal axis interactions in Table 2 may not be comprehensive due to the introduction of new drugs that interact with thyroidal axis or discovery of previously unknown interactions. Prescribers should be aware of this fact and should consult appropriate reference sources for additional information if drug - drug interaction with levothyroxine is suspect.


Pharmacology

Thyroid hormone synthesis and secretion is regulated by the hypothalamic - pituitary - thyroid axis. Thyrotropin - releasing hormone release from the hypothalamus stimulates secretion of thyrotropin - stimulating hormone, TSH, from the anterior pituitary. Tsh, in turn, is physiologic stimulus for synthesis and secretion of thyroid hormones, L - thyroxine and L - triiodothyronine, by thyroid gland. Circulating serum T 3 and T 4 levels exert feedback effect on both TRH and TSH secretion. When serum T 3 and T 4 levels increase, TRH and TSH secretion decrease. When thyroid hormone levels decrease, TRH and TSH secretion increase. Mechanisms by which thyroid hormones exert their physiologic actions are not completely understood, but it is thought that their principal effects are exerted through control of DNA transcription and protein synthesis. T 3 and T 4 diffuse into cell nucleus and bind to thyroid receptor proteins that attach to DNA. This hormone nuclear receptor complex activates gene transcription and synthesis of messenger RNA and cytoplasmic proteins. Thyroid hormones regulate multiple metabolic processes and play an essential role in normal growth and development, and normal maturation of the central nervous system and bone. Metabolic actions of thyroid hormones include augmentation of cellular respiration and thermogenesis, as well as metabolism of proteins, carbohydrates and lipids. Protein anabolic effects of thyroid hormones are essential to normal growth and development. Physiological actions of thyroid hormones are produced predominantly by T 3, majority of which is derived from T 4 by deiodination in peripheral tissues. Levothyroxine, at doses individualized according to patient response, is effective as replacement or supplemental therapy in hypothyroidism of any etiology, except transient hypothyroidism during recovery phase of subacute thyroiditis. Levothyroxine is also effective in suppression of pituitary TSH secretion in treatment or prevention of various types of euthyroid goiters, including thyroid nodules, Hashimoto's thyroiditis, multinodular goiter AND, as adjunctive therapy in management of thyrotropin - dependent welldifferentiated thyroid cancer.


Side Effects

Pseudotumor cerebri and slip capital femoral epiphysis have been reported in children receiving levothyroxine therapy. Overtreatment may result in craniosynostosis in infants and premature closure of epiphyses in children with resultant compromise adult height. Seizures have been reported rarely with institution of levothyroxine therapy. Inadequate levothyroxine dosage will produce or fail to ameliorate signs and symptoms of hypothyroidism. Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone products. These include urticaria, pruritus, skin rash, flushing, angioedema, various GI symptoms, fever, arthralgia, serum sickness and wheezing. Hypersensitivity to levothyroxine itself is not known to occur.


What is levothyroxine?

Generic bioequivalence data confirm medical societies concern about recently approved generic Levothyroxine preparations. Two organizations representing more than 5 400 Clinical Endocrinologists today warn patients taking Thyroid medication, prescribing physicians, and pharmacists dispensing these drugs that clinically important differences do, in fact, exist between one recently approved generic Levothyroxine preparation and the most widely prescribed brand of Levothyroxine. Members of these organizations, American Thyroid Association and American Association of Clinical Endocrinologists, specialize in treatment of hormonal disorders. Levothyroxine is taken by more than 13 million Americans to treat underactive Thyroid, Thyroid gland enlargement, nodules, or cancer. In June, Food and Drug Administration ruled that several generic Levothyroxine preparations had the same clinical effect and safety profile as certain branded products. As a result, pharmacists may substitute patients ' current Levothyroxine preparation for another, sometimes without their physicians ' approval. According to bioequivalence data used to acquire FDA approval, one recently approved generic Levothyroxine preparation is significantly more potent than the most widely used brand of Levothyroxine. Information from bioequivalence studies submitted to FDA show that new generics may be as much as one - eighth more potent than widely prescribed branded product. Furthermore, Levothyroxine is a drug known to have narrow toxic - to - therapeutic ratio with significant clinical consequences of even minor excessive or inadequate dosing. Potential adverse events include symptoms, osteoporosis, atrial fibrillation, worsening of heart disease, preterm delivery in pregnancy, impaired fetal brain development, and high cholesterol. Unfortunately, this information confirms our concern that current FDA standards defining equivalence of Levothyroxine products are too lax, says Carlos Hamilton, MD, AACE President. Switching between two products could compromise the effectiveness of treatment and even result in serious side effects. Ata and AACE have repeatedly expressed their concerns about FDA's recent decision to approve generic substitutes for Levothyroxine products and its implications for millions of Americans who depend on this drug. Societies have also made public their disappointment that FDA made their decision before considering input offered by Clinical Endocrinologists, recognize experts who care for Thyroid patients. Both the FDA and societies recommend that patients switching between Levothyroxine products have repeated Thyroid blood testing to be certain that treatment dose remain effective and safe. Under the policy of allowing generic Levothyroxine substitution, say Gregory Brent, MD, ATA Secretary, more frequent Thyroid function testing will be necessary. Regrettably, some patients and doctors will not even be aware of change in preparation before adverse events occur. Ata and AACE advise physicians caring for patients on Levothyroxine therapy to alert patients that their Levothyroxine preparation may be switched at pharmacy, Encourage patients to remain on their current Levothyroxine preparation when possible, Ensure that patients understand if they receive new Levothyroxine preparation that they will need to repeat Thyroid - stimulating hormone blood test four to six weeks later to determine if they need further dose adjustment.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Hashimoto's Thyroiditis

Fluctuating TSH, potential problem if your pharmacy switches between generic levothyroxine from different manufacturers, is particularly concern if you re a Thyroid cancer survivor. This population requires careful and consistent dosing in order to suppress TSH as a way to prevent cancer recurrence. If you 've had Thyroid cancer, talk to your doctor about the pros and cons of taking generics. For several years, liquid, softgel capsule form of levothyroxine has been available in the United States under the brand name Tirosint. It was designed primarily as a hypoallergenic, specialized form of levothyroxine for people who have digestive or intestinal issues, difficulties with absorption of thyroid medication, or allergies to fillers and binders in tablet formulations of levothyroxine drugs. A study that was presented at the 2017 American Thyroid Association conference compared the effectiveness of levothyroxine tablets, usual formulation, and softgels in patients who had total thyroidectomy for multinodular goiter. None of the patients had any issues with absorption. Around half of patients studied were given levothyroxine tablets, and the other half received softgel capsules at the same dosage, starting immediately after thyroid surgery. Patients with TSH, free thyroxine, and free triiodothyronine levels were evaluated after six weeks and then after 12 weeks. At both six and 12 weeks, patients taking softgel capsules had significantly lower TSH levels and at both measurement points, number of patients who had elevated TSH levels was above 3. 5 mcU / mldeemed hypothyroid for this studywas significantly higher in patients receiving tablets. Researchers conclude that even in patients who had no malabsorption or digestive issues, softgel formulation was more effective.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

USE

Most drugs do not differ much in their generic and brand name forms, so switching between two is not a big issue. Levothyroxine, however, is one of a handful of exceptions. Manufacturers of any preparation of levothyroxine must ensure that their drug is within 5 percent of its stated potency, which must be between 95 percent and 105 percent, per FDA. This leaves room for meaningful differences between your levothryoxine options. Give that the FDA allows such variation, it's easy to think that it can't have much effect. But levothyroxine has what's called a narrow therapeutic window, meaning that treatment must be fine - tune in order to achieve desired effects. Though the potency of one levothyroxine option may seem marginally different than another, discrepancy could lead you to take anywhere from around half a pill less or entire pill more over the course of a week if you make switcheven if you re taking the same dosage as you were before. This can dramatically influence your thyroid disease management. If you switch from brand name to generic preparation, you may notice that you don't feel as well on generic drug and may have symptoms of hypo - or hyperthyroidism. While this can be due to the drug's dosage and potency, it can also be due to: how much of levothyroxine is available for absorption by body amount of levothyroxine circulating in your body after dose. Some people are especially prone to exacerbating symptoms when making any change to their thyroid drug regimen. While chemical structure and safety profiles of brand - name and generic versions themselves are the same, even small differences in dosage strength can cause symptoms, which must be consider, especially if you are dealing with thyroid disease - related complications or co - occuring conditions, like heart disease. In addition, additional ingredients found in different versions of levothyroxine may pose safety concerns for people with allergies or sensitivities. Fillers and additives such as dyes, gluten, and lactose are also less consistent in generics than brand - name options because they originate from different manufacturers. If this is a concern for you, ask your pharmacist for a list of your prescribed drug's ingredients. Additional chemicals added to drugs are usually considered inert or inactive, but studies have found that these inactive ingredients can sometimes decrease the effectiveness of particular drug.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Tirosint Important Safety Information

Adverse reactions associated with TIROSINT therapy are primarily those of hyperthyroidism due to therapeutic overdosage. They include the following: general: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia, musculoskeletal: tremors, muscle weakness, muscle spasm, Cardiovascular: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest, Respiratory: dyspnea Gastrointestinal: diarrhea, vomiting, abdominal cramps, elevations in liver function tests Dermatologic: hair loss, flushing, rash Endocrine: decrease bone mineral density Reproductive: menstrual irregularities, impaired fertility seizures have been report rarely with institution of levothyroxine therapy. Pseudotumor cerebri and slip capital femoral epiphysis have been reported in children receiving levothyroxine therapy. Overtreatment may result in craniosynostosis in infants and premature closure of epiphyses in children with resultant compromise adult height. Hypersensitivity reactions to inactive ingredients have occurred in patients treated with Thyroid hormone products. These include urticaria, pruritus, skin rash, flushing, angioedema, various GI symptoms, fever, arthralgia, serum sickness and wheezing. Hypersensitivity to levothyroxine itself is not known to occur.


Side Effects

Adverse reactions associated with TIROSINT therapy are primarily those of hyperthyroidism due to therapeutic overdosage. They include the following: general: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia, musculoskeletal: tremors, muscle weakness, muscle spasm, Cardiovascular: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest, Respiratory: dyspnea Gastrointestinal: diarrhea, vomiting, abdominal cramps, elevations in liver function tests Dermatologic: hair loss, flushing, rash Endocrine: decrease bone mineral density Reproductive: menstrual irregularities, impaired fertility seizures have been report rarely with institution of levothyroxine therapy.


Uses

Levothyroxine is used to treat underactive thyroid gland. It replaces or provides more thyroid hormone, which are normally produced by thyroid gland. Low thyroid hormone levels can occur naturally or when the thyroid gland is injured by radiation / medications or removed by surgery. Having enough thyroid hormones is important for normal mental and physical activity. In children, having enough thyroid hormones is important for normal mental and physical development. This medication is also used to treat other types of thyroid disorders. This medication should not be used to treat infertility unless it is caused by low thyroid hormone levels.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Drug Class: Thyroid products

Levothyroxine sodium is a drug approved by FDA as an oral and injectable prescription thyroid hormone medication that is used to treat underactive thyroid and other conditions. Hypothyroidism is a medical term that refers to any state in which a person's thyroid hormone production is below normal. This medication replaces or provides thyroid hormone support, which is normally produced by the thyroid gland. Low thyroid hormone levels can occur naturally or when the thyroid gland is injured by radiation / medications or removed by surgery. Having enough thyroid hormones is important for maintaining normal mental health and physical activity. In children, having enough thyroid hormones is important for normal mental and physical development. Levothyroxine is also know as L - thyroxine.


Uses

Read Patient Information Leaflet if available from your pharmacist before you start taking levothyroxine and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually once daily on an empty stomach, 30 minutes to 1 hour before breakfast. Take this medication with a full glass of water unless your doctor directs you otherwise. If you are taking capsule form of this medication, swallow it whole. Do not split, crush, or chew. People who cannot swallow capsules whole should use tablet form of medication. For infants or children who cannot swallow whole tablets, crush the tablet and mix in 1 to 2 teaspoons of water, and give using a spoon or dropper right away. Do not prepare supply in advance or mix tablets in soy infant formula. Consult your pharmacist for more information. Dosage is based on your age, weight, medical condition, laboratory test results, and response to treatment. Use this medication regularly in order to get most benefit from it. To help you remember, take it at same time each day. Do not stop taking this medication without first consulting with your doctor. Thyroid replacement treatment is usually taken for life. There are different brands of levothyroxine available. Do not change brands without first consulting your doctor or pharmacist. Certain medications can decrease the amount of thyroid hormone that is absorbed by your body. If you are taking any of these drugs, separate them from this medication for at least 4 hours. Symptoms of low thyroid hormone levels include tiredness, muscle aches, constipation, dry skin, weight gain, slow heartbeat, or sensitivity to cold. Tell your doctor if your condition worsens or persists after several weeks of taking this medication.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Symptoms of Hypothyroidism

Symptoms of hypothyroidism are dependent on the health of the thyroid and efficient production of thyroid hormone, but can include: increased cholesterol levels, depression, fatigue, hair loss, memory loss, dry, rough skin, and constipation. Levothyroxine sodium is also used to treat other types of thyroid hormone and thyroid disorders and conditions. Levothyroxine sodium should not be used to treat infertility unless it is caused by low thyroid hormone levels. Levothyroxine sodium is available under the following different brand names: Synthroid, Levoxyl, L Thyroxine, Levo T, Levothroid, Levothyroxine T4, Levoxine, Tirosint, and Unithroid.


SIDE EFFECTS

Adverse reactions associated with levothyroxine therapy are primarily those of hyperthyroidism due to therapeutic overdosage. They include the following: general: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating; central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia; cardiac: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest; pseudotumor cerebri and slip capital femoral epiphysis have been report in children receiving levothyroxine therapy. Overtreatment may result in craniosynostosis in infants and premature closure of epiphyses in children with resultant compromise adult height. Seizures have been reported rarely with institution of levothyroxine therapy. Inadequate levothyroxine dosage will produce or fail to ameliorate signs and symptoms of hypothyroidism. Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone products. These include urticaria, pruritus, skin rash, flushing, angioedema, various GI symptoms, fever, arthralgia, serum sickness and wheezing. Hypersensitivity to levothyroxine itself is not known to occur. In addition to the above events, following has been report, predominately when Levoxyl tablets were not taken with water: choking, gagging, tablet stuck in throat and dysphagia. Read entire FDA prescribing INFORMATION for Levoxyl


What is levothyroxine?

Generic levothyroxine may differ slightly from Synthroid in terms of how well it is absorbed. That is why it is preferable to stick with either one if possible. Both the American Thyroid Association and the Endocrine Society recommend that patients remain on Synthroid if that is what was initially prescribe. If you are on generic levothyroxine, try to stick with the same generic manufactureryour pharmacist can help you with that. What about switching from Synthroid to desiccated Thyroid extract like Armour Thyroid? Many studies have compared Synthroid to desiccated Thyroid extract and revealed no differences in symptoms and neurocognitive measurements between the two groups.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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