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Levothyroxine Used

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Last Updated: 16 October 2020

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General | Latest Info

Levothyroxine is a synthetic version of the principal thyroid hormone, Thyroxine that is made and released by the thyroid gland. Thyroid hormone increases the metabolic rate of cells of all tissues in the body. In fetus and newborn, thyroid hormones are important for growth and development of all tissues, including bones and the brain. In adults, thyroid hormones help to maintain brain function, utilization of food, and body temperature, among other effects. Generic AVAILABLE: Yes. Generic and branded tablets of Levothyroxine may differ: in amount of Levothyroxine they contain, absorption of Levothyroxine into the body, and distribution of Levothyroxine throughout the body. This means that ingestion OF 1 mg OF GENERIC Levothyroxine may not have the same effect on the body as 1 mg OF another GENERIC or branded Levothyroxine. Practically speaking, this means that when changing between Levothyroxine manufactured by different pharmaceutical companies, change in dose may be necessary to maintain the desired effect or to prevent toxicity. When switching between brands or generics, it is important to ensure that both preparations ARE equivalent or to check blood thyroid levels weekly. For adult hypothyroidism, Levothyroxine starts at 12. 5 - 125 mcg / day administered orally. Starting doses and dose changes may differ with individual patients based upon age, presence OF cardiovascular disease, development OF tolerance, side effects of medication, and blood levels OF thyroid hormone. It may take one to three weeks after initiating therapy with Levothyroxine or changing dose before effects ARE see. The goal of replacement therapy is to maintain normal blood thyroxine level. Initiation or discontinuation OF therapy with Levothyroxine in diabetic patients may create a need for an increase or decrease in the required dose OF insulin and / or antidiabetic drug,. Levothyroxine may increase the effect of blood thinners such as warfarin. Therefore, monitoring for blood clotting is necessary, and a decrease in the dose of warfarin may be necessary. Intravenous administration of epinephrine to patients with coronary artery disease may lead to complications ranging from difficulty in breathing to heart attack. These complications may occur more frequently among patients also taking Levothyroxine. Therefore, careful observation is needed when intravenous epinephrine is given to patients receiving Levothyroxine who also have coronary artery disease. Converting state OF hypothyroidism to a normal state with Levothyroxine may decrease actions OF certain beta - blocking drugs,. It may be necessary, therefore, to change the dose of beta - blocker. For the same reason, dose of digoxin, drug used to manage heart failure or irregular heart rhythm, also may need to be change. Converting hypothyroidism to euthyroid state with Levothyroxine may increase the blood level OF theophylline, and it may be necessary to change the dose OF theophylline. Taking Levothyroxine at the same time as calcium carbonate, ferrous sulfate, cholestyramine or colestipol may decrease the effect of Levothyroxine and lead to hypothyroidism. This occurs because Levothyroxine binds to these drugs and is not absorb.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Uses

Levothyroxine is used to treat underactive thyroid. It replaces or provides more thyroid hormone, which are normally produced by thyroid gland. Low thyroid hormone levels can occur naturally or when the thyroid gland is injured by radiation / medications or removed by surgery. Having enough thyroid hormone is important for maintaining normal mental and physical activity. In children, having enough thyroid hormones is important for normal mental and physical development. This medication is also used to treat other types of thyroid disorders. This medication should not be used to treat infertility unless it is caused by low thyroid hormone levels.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Side Effects

Levothyroxine should not be used alone or along with other treatments to treat obesity or cause weight loss. Levothyroxine may cause serious or life - threatening problems when given in large doses, especially when taken with amphetamines such as amphetamine, dextroamphetamine, and methamphetamine. Tell your doctor if you have any of the following symptoms while you are taking levothyroxine: chest pain, rapid or irregular heartbeat or pulse, uncontrollable shaking of part of your body, nervousness, anxiety, irritability, difficulty falling asleep or staying asleep, shortness of breath, or excessive sweating. Talk to your doctor about potential risks associated with this medication. Levothyroxine is used to treat hypothyroidism. It is also used with surgery and radioactive iodine therapy to treat thyroid cancer. Levothyroxine is in a class of medications called hormones. It works by replacing thyroid hormone that is normally produced by the body. Without thyroid hormone, your body cannot function properly, which may result in poor growth, slow speech, lack of energy, excessive tiredness, constipation, weight gain, hair loss, dry, thick skin, increased sensitivity to cold, joint and muscle pain, heavy or irregular menstrual periods, and depression. When taken correctly, levothyroxine reverses these symptoms. Levothyroxine comes as a tablet and capsule to take by mouth. It usually takes once a day on an empty stomach, 30 minutes to 1 hour before breakfast. Follow directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take levothyroxine exactly as direct. Do not take more or less of it or take it more often than prescribed by your doctor. Swallow capsules whole; do not chew or crush them. Do not remove the capsule from the package until you are ready to take it. Take tablets with a full glass of water as they may get stuck in your throat or cause choking or gagging. If you are giving levothyroxine to an infant, child, or adult who cannot swallow tablet,ss crush and mix it with 1 to 2 teaspoons of water. Only mix crush tablets with water; do not mix them with food or soybean infant formula. Give this mixture by spoon or dropper right away. Do not store it for later use. Your doctor will probably start you on a low dose of levothyroxine and gradually increase your dose. Levothyroxine controls hypothyroidism but does not cure it. It may take several weeks before you notice a change in your symptoms. Continue to take levothyroxine even if you feel well. Do not stop taking levothyroxine without talking to your doctor.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

What is levothyroxine?

Levothyroxine should not be used to treat obesity or weight problems. Dangerous side effects or death can occur from misuse of levothyroxine, especially if you are taking any other weight - loss medications or appetite suppressants. Since thyroid hormones occur naturally in the body, almost anyone can take levothyroxine. However, you may not be able to take this medicine if you have certain medical conditions. Tell your doctor if you have: untreated or uncontrolled adrenal gland disorder; thyroid disorder called thyrotoxicosis; or symptoms of heart attack. Thyroid nodule;s heart disease, blood clot, or blood - clotting disorder; diabetes; kidney disease; anemia; osteoporosis, or low bone mineral density; problems with your pituitary gland; or any food or drug allergies. Tell your doctor if you have recently received radiation therapy with iodine. If you become pregnant while taking levothyroxine, do not stop taking medicine without your doctor's advice. Having low thyroid hormone levels during pregnancy could harm both mother and baby. Your dose needs may be different during pregnancy. Tell your doctor if you are breast - feeding. Your dose needs may be different while you are nursing. Do not give this medicine to child without medical advice. Tirosint is not approved for use by anyone younger than 6 years old.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Warnings

Over - treatment with Levothyroxine may cause an increase in heart rate, cardiac wall thickness, and cardiac contractility and may precipitate Angina or arrhythmias, particularly in patients with cardiovascular disease and in elderly patients. Initiate SYNTHROID therapy in this population at lower doses than those recommended in younger individuals or in patients without cardiac disease. Monitor for cardiac arrhythmias during surgical procedures in patients with coronary artery disease receiving suppressive SYNTHROID therapy. Monitor patients receiving concomitant SYNTHROID and sympathomimetic agents for signs and symptoms of coronary insufficiency. If cardiac symptoms develop or worsen, reduce SYNTHROID dose or withhold it for one week and restart at lower dose. Myxedema coma is a life - threatening emergency characterized by poor circulation and hypometabolism, and may result in unpredictable absorption of Levothyroxine Sodium from the gastrointestinal tract. Use of oral thyroid hormone drug products is not recommended to treat myxedema coma. Administer thyroid hormone products formulated for intravenous administration to treat myxedema coma. Thyroid hormone increases metabolic clearance of glucocorticoids. Initiation of thyroid hormone therapy prior to initiating glucocorticoid therapy may precipitate acute adrenal crisis in patients with adrenal insufficiency. Treat patients with adrenal insufficiency with replacement glucocorticoids prior to initiating treatment with SYNTHROID. The Synthroid has a narrow therapeutic index. Over - or undertreatment with SYNTHROID may have negative effects on growth and development, cardiovascular function, bone metabolism, reproductive function, cognitive function, emotional state, gastrointestinal function, and glucose and lipid metabolism. Titrate dose of SYNTHROID carefully and monitor response to titration to avoid these effects. Monitor for presence of drug or food interactions when using SYNTHROID and adjust dose as necessary. Addition of Levothyroxine therapy in patients with Diabetes mellitus may worsen glycemic control and result in increased antidiabetic agent or insulin requirements. Carefully monitor glycemic control after starting, changing, or discontinuing SYNTHROID. Increase bone resorption and decreased bone mineral density may occur as a result of Levothyroxine over - replacement, particularly in post - menopausal women. Increased bone resorption may be associated with increased serum levels and urinary excretion of Calcium and phosphorous, elevations in bone alkaline phosphatase, and suppressed serum parathyroid hormone levels. Administer minimum dose of SYNTHROID that achieves the desired clinical and biochemical response to mitigate this risk.


SIDE EFFECTS

Adverse reactions associated with levothyroxine therapy are primarily those of hyperthyroidism due to therapeutic overdosage. They include the following: general: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating; central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia; cardiac: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest; pseudotumor cerebri and slip capital femoral epiphysis have been report in children receiving levothyroxine therapy. Overtreatment may result in craniosynostosis in infants and premature closure of epiphyses in children with resultant compromise adult height. Seizures have been reported rarely with institution of levothyroxine therapy. Inadequate levothyroxine dosage will produce or fail to ameliorate signs and symptoms of hypothyroidism. Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone products. These include urticaria, pruritus, skin rash, flushing, angioedema, various GI symptoms, fever, arthralgia, serum sickness and wheezing. Hypersensitivity to levothyroxine itself is not known to occur. In addition to the above events, following has been report, predominately when Levoxyl tablets were not taken with water: choking, gagging, tablet stuck in throat and dysphagia. Read entire FDA prescribing INFORMATION for Levoxyl

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Take as directed

Levothyroxine oral tablet is used for long - term treatment. It comes with serious risks if you do take it as prescribe. If you stop taking drug or do take it at all: Your thyroid hormones will remain low, which may result in low energy levels, tiredness, weakness, slower speech, constipation, or thickened skin. It may even lead to coma. If you miss doses or do take drugs on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, certain amount needs to be in your body at all times. If you take too much: you could have dangerous levels of drugs in your body. Symptoms of overdose can include: confusion, disorientation, stroke, shock coma. If you think youve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away. What to do if you miss dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects. How to tell if a drug is working: You should feel your symptoms of low thyroid hormone decrease. For instance, you should have more energy, less tiredness, and less weakness.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

8. Cautions with other medicines

Some medicines can interfere with thyroid hormones, so the dose of Levothyroxine may need to be change. They include: medicines for fits or seizures - such as carbamazepine and Phenytoin rifampicin amiodarone oestrogens - such as in combined contraceptive pills or hormone replacement therapy. Levothyroxine can change how other medicines work, so their doses may need to be alter. These medicines include: medicines for Diabetes - either insulin or tablets, Blood thinning medicine, warfarin. Some medicines should not be taken at the same time of day as Levothyroxine as they can reduce the amount of Levothyroxine your body takes in, including: antacids, Calcium salts, Iron salts orlistat, medicine used for weight loss sucralfate, medicine used to treat stomach ulcers, some cholesterol - lowering medicines such as colestyramine, colestipol or colesevelem read information leaflet supply with these medicines or speak to your pharmacist for advice on how much time to leave between taking these medicines and taking Levothyroxine.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Description and Brand Names

Symptoms of hypothyroidism depend on the health of the thyroid and efficient production of thyroid hormone, but can include: increased cholesterol levels, depression, fatigue, hair loss, memory loss, dry, rough skin, and constipation. Levothyroxine sodium is also used to treat other types of thyroid hormone and thyroid disorders and conditions. Levothyroxine sodium should not be used to treat infertility unless it is caused by low thyroid hormone levels. Levothyroxine sodium is available under the following different brand names: Synthroid, Levoxyl, L Thyroxine, Levo T, Levothroid, Levothyroxine T4, Levoxine, Tirosint, and Unithroid.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Precautions

In deciding to use medicine, risks of taking medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, following should be consider: tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non - prescription products, read the label or package ingredients carefully. Appropriate studies performed to date have not demonstrated Pediatric - specific problems that would limit the usefulness of Levothyroxine in children. Appropriate studies performed to date have not demonstrated Geriatric - specific problems that would limit the usefulness of Levothyroxine in the elderly. However, elderly patients are more likely to have age - related heart or blood vessel problems, which may require caution and adjustment in dose for patients receiving Levothyroxine. Studies in women suggest that this medication poses minimal risk to infants when used during breastfeeding. Although certain medicines should not be used together at all, in other cases, two different medicines may be used together even if interaction might occur. In these cases, your doctor may want to change dose, or other PRECAUTIONS may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any OF medicines listed below. Following INTERACTIONS have been selected on the basis of their potential significance and are not necessarily all - inclusive. Using this medicine with any OF following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both OF medicines. Midodrine Using this medicine with any OF following medicines may cause increased risk OF certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both OF medicines. Aluminum Carbonate, Basic Aluminum Hydroxide Aluminum Phosphate Calcium Acetate Calcium Carbonate Calcium Citrate Chlorotrianisene Cholestyramine Chromium Ciprofloxacin Colesevelam conjugate Estrogens conjugate Estrogens Synthetic conjugate Estrogens Synthetic B Dexlansoprazole Dienestrol Diethylstilbestrol Dihydroxyaluminum Aminoacetate Dihydroxyaluminum Sodium Carbonate Eltrombopag Esomeprazole esterify Estrogens Estradiol Estramustine Estriol Estropipate Ethinyl Estradiol Fosphenytoin Imatinib Iron Kelp Lansoprazole Lanthanum Carbonate Lopinavir Magaldrate Magnesium Carbonate Magnesium Hydroxide Magnesium Oxide Magnesium Trisilicate Mestranol Omeprazole Pantoprazole Patiromer Phenytoin Polyestradiol Phosphate Promestriene Quinestrol Rabeprazole Rifampin Ritonavir Semaglutide Sevelamer Simvastatin Tibolone certain medicines should not be Use at or around time OF eating food or eating certain types OF food since INTERACTIONS may occur. Using alcohol or tobacco with certain medicines may also cause INTERACTIONS to occur. Following INTERACTIONS have been selected on the basis of their potential significance and are not necessarily all - inclusive.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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