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Levsin Sl

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Last Updated: 16 September 2020

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General | Latest Info

Levsin SL is one of the principal anticholinergic / antispasmodic components of belladonna alkaloids used to treat many different stomach and intestinal disorders, including peptic ulcer and irritable bowel syndrome. Levsin SL is also used to control muscle spasms in the bladder, kidneys, or digestive tract, and to reduce stomach acid, and is sometimes used to reduce tremors and rigid muscles in people with symptoms of Parkinson's disease. Levsin SL may be available in generic form. Common side effects of Levsin SL include: dizziness, drowsiness, blurred vision, dry mouth, vision problems, headache, trouble sleeping, constipation, flushing, dry skin, decrease sweating, nervousness, nausea, vomiting, bloating, heartburn, changes in taste, problems with urination, impotence, loss of interest in sex, or trouble having orgasm. Tell your doctor if you have unlikely but serious side effects of Levsin SL, including: mental / mood changes, fast or irregular heartbeat, loss of coordination, or slur speech. The dose of Levsin SL for adults and children 12 years of age and older is 1 to 2 Tablets every four hours or as needed. Do not exceed 12 Tablets in 24 hours. For pediatric patients 2 to under 12 years of age: to 1 tablet every four hours or as needed Do not exceed 6 tablets in 24 hours. Tablets may be taken sublingually, orally or chew. Levsin SL may interact with amantadine, haloperidol, MAO inhibitors, phenothiazines, or antidepressants. Tell your doctor all the medications and supplements you use. Levsin SL should be used only when prescribed during pregnancy. This drug pass into breast milk. Consult your doctor before breastfeeding. Our Levsin SL side Effects Drug Center provides a comprehensive view of available drug information on potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 - 800 - FDA - 1088. Get emergency medical help if you have signs of allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using hyoscyamine and call your doctor at once if you have: anxiety, confusion, hallucinations, unusual thoughts or behavior; weakness, memory problems; slurred speech; problems with balance or muscle movement; diarrhea; or pounding heartbeats or fluttering in your chest. Dizziness, drowsiness, feeling weak or tire; decreased sweating, decreased urination; blurred vision; rash; dry mouth, decreased sense of taste; stomach pain, nausea, vomiting, bloating; diarrhea, constipation; headache; sleep problems; or impotence, loss of interest in sex, or trouble having orgasm. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 - 800 - FDA - 1088. Read the entire detailed patient monograph for Levsin SL

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

SIDE EFFECTS

Dizziness, drowsiness, blurred vision, dry mouth, headache, trouble sleeping, constipation, flushing, dry skin, and decreased sweating may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. To relieve dry mouth, suck on hard candy or ice chips, chew gum, drink water or use saliva substitute. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if any of these unlikely but serious side effects occur: mental / mood changes, fast / irregular heartbeat, difficulty urinating, decreased sexual ability, loss of coordination, slur speech, vomiting. Get medical help right away if you have any very serious side effects, including: eye pain / swelling / redness, vision changes. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occur. Symptoms of serious allergic reaction may include: rash, itching / swelling, severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 - 800 - FDA - 1088 or at www. Fda. Gov / medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1 - 866 - 234 - 2345.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Uses

Hyoscyamine is used to treat a variety of stomach / intestinal problems such as cramps and irritable bowel syndrome. It is also used to treat other conditions such as bladder and bowel control problems, cramping pain caused by kidney stones and gallstones, and Parkinson's disease. In addition, it is used to decrease side effects of certain medications and insecticides. This medication works by decreasing acid production in the stomach, slowing down natural movements of the gut, and relaxing muscles in many organs. Hyoscyamine also lessens the amount of certain body fluids. This medication belongs to the class of drugs know as anticholinergics / antispasmodics.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use and share it with your doctor and pharmacist. Do not start, stop, or change dosage of any medicines without your doctor's approval. Some products that may interact with this drug are: certain anti - arrhythmic drugs, anticholinergic drugs, antispasmodic drugs, certain anti - Parkinson's drugs, certain azole anti - fungal drugs, belladonna alkaloids, bisphosphonate drugs, corticosteroids, digoxin, MAO inhibitors, potassium tablets / capsules, pramlintide. Tell your doctor or pharmacist if you are taking other products that cause drowsiness, such as opioid pain or cough relievers, alcohol, marijuana, drugs for sleep or anxiety, muscle relaxants, or antihistamines. Check labels on all your medicines because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. This product can affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Indications and dosages

Levsin is effective as adjunctive therapy in treatment of peptic ulcer.S It can also be used to control gastric secretion, visceral spasm and hypermotility in spastic colitis, spastic bladder, cystitis, pylorospasm, and associated abdominal cramps. May be used in functional intestinal disorders to reduce symptoms such as those seen in mild dysenteries, diverticulitis, and acute enterocolitis. For use as adjunctive therapy in treatment of irritable bowel syndrome and functional gastrointestinal disorders. Also used as adjunctive therapy in treatment of neurogenic bladder and neurogenic bowel disturbances. Also used in the treatment of infant colic. Levsin is indicated along with morphine or other narcotics in symptomatic relief of biliary and renal colic; as a drying agent in relief of symptoms of acute rhinitis; in therapy of parkinsonism to reduce rigidity and tremors and to control associated sialorrhea and hyperhidrosis. May be used in therapy of poisoning by anticholinesterase agents.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Warnings

In the presence of high environmental temperature,s heat prostration can occur with drug use. Diarrhea may be an early symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. In this instance, treatment with this drug would be inappropriate and possibly harmful. Like other anticholinergic agents, Levsin / SL may produce drowsiness, dizziness or blurred vision. In this event, patients should be warned not to engage in activities requiring mental alertness such as operating motor vehicles or other machinery or to perform hazardous work while taking this drug. Psychosis has been reported in sensitive individuals given anticholinergic drugs including hyoscyamine sulfate. Cns signs and symptoms include confusion, disorientation, short - term memory loss, hallucinations, dysarthria, ataxia, euphoria, anxiety, fatigue, insomnia, agitation and mannerisms, and inappropriate affect. These CNS signs and symptoms usually resolve within 12 to 48 hours after discontinuation of the drug.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

DOSAGE AND ADMINISTRATION

Medically reviewed by drugs. Com. It was last updated on Apr 21 2020. Levsin / SL tablets contain 0. 125 mg hyoscyamine sulfate formulated for sublingual administration. However, tablets may be chewed or taken orally. Levsin / SL is one of the principal anticholinergic / antispasmodic components of belladonna alkaloids. The empirical formula is 2 H 2 SO 4 2H 2 O and the molecular weight is 712. 85. Chemically, it is benzeneacetic acid, ~-, 8 - methyl - 8azabicyclo oct - 3yl ester, -, sulfate, dihydrate with the following structure: each tablet also contains as inactive ingredients: FD & C blue 1, lactose monohydrate, magnesium stearate, mannitol, starch and stearic acid. Levsin / SL inhibits specifically actions of acetylcholine on structures innervate by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These peripheral cholinergic receptors are present in autonomic effector cells of smooth muscle, cardiac muscle, sinoatrial node, atrioventricular node, and exocrine glands. At therapeutic doses, it is completely devoid of any action on autonomic ganglia. Levsin / SL inhibits gastrointestinal propulsive motility and decreases gastric acid secretion. Levsin / SL also controls excessive pharyngeal, tracheal and bronchial secretions. Levsin / SL is absorbed totally and completely by sublingual administration as well as oral administration. Once absorb, Levsin / SL disappears rapidly from blood and is distributed throughout the entire body. The half - life of Levsin / SL is 2 to 3 hours. Levsin / SL is partly hydrolyze to tropic acid and tropine but the majority of the drug is excreted in urine unchanged within the first 12 hours. Only traces of this drug are found in breast milk. Levsin / SL passes the blood brain barrier and placental barrier. Tablets can be taken orally with the same pharmacological effects occurring; however, effects may not occur as rapidly as with sublingual administration. Levsin / SL is effective as adjunctive therapy in treatment of peptic ulcer.S It can also be used to control gastric secretion, visceral spasm and hypermotility in spastic colitis, spastic bladder, cystitis, pylorospasm, and associated abdominal cramps. May be used in functional intestinal disorders to reduce symptoms such as those seen in mild dysenteries, diverticulitis, and acute enterocolitis. For use as adjunctive therapy in treatment of irritable bowel syndrome and functional gastrointestinal disorders. Also used as adjunctive therapy in treatment of neurogenic bladder and neurogenic bowel disturbances. Also used in the treatment of infant colic. Levsin / SL is indicated along with morphine or other narcotics in symptomatic relief of biliary and renal colic; as a drying agent in relief of symptoms of acute rhinitis; in therapy of parkinsonism to reduce rigidity and tremors and to control associated sialorrhea and hyperhidrosis. May be used in therapy of poisoning by anticholinesterase agents. Glaucoma; obstructive uropathy; obstructive disease of gastrointestinal tract: paralytic ileus, intestinal atony of elderly or debilitated patients; unstable cardiovascular status in acute hemorrhage; severe ulcerative colitis; toxic megacolon complicating ulcerative colitis; myasthenia gravis. In the presence of high environmental temperature,s heat prostration can occur with drug use.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

HOW SUPPLIED

Levsin / SL tablets 0. 125 mg are round, blue colored tablets that are imprinted with AP on one side and 113 on the other. Bottles of 100 tablets NDC 68220 - 113 - 10 Bottles of 500 tablets NDC 68220 - 113 - 50 stored at controlled room temperature of 20 - 25C; excursions permitted to15 - 30C. Please refer to current USP. Dispense in tight, light - resistant containers as defined in USP / NF with child - resistant closure. Manufacture for: Alaven Pharmaceutical LLC, Marietta, GA 30067. Address medical inquiries to: Alaven Pharmaceutical LLC, 2260 Northwest Parkway, Suite, Marietta, GA 30067 or call toll free 1 - 888 - 317 - 0001. Rev: 02 / 08.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

PRECAUTIONS

The Anticholinergic effects of hyoscyamine may be significant and are additive to other anticholinergic medications. This is especially true for older adult,sss but may also occur with any patient. Consider the anticholinergic burden of all applicable medication therapies and consider the potential for additive side effects. Hyoscyamine decreases bronchial secretions and should be used cautiously in patients with chronic pulmonary disease. Inspissation and formation of bronchial plugs may occur in these patients. Hyoscyamine should be used cautiously in patients with hepatic disease, renal impairment, or renal disease. The drug is metabolized by liver and resultant metabolites as well as unchanged drugs are excreted in the kidneys. Further, hyoscyamine can cause urinary retention. Hyoscyamine is therefore contraindicate in patients with bladder obstruction or other urinary tract obstruction because it may aggravate urinary retention. In addition, hyoscyamine should be used with caution in patients with prostatic hypertrophy. Hyoscyamine is contraindicated for use in patients with myasthenia gravis because anticholinergic competes with small amount of acetylcholine that has potential to act in the body in these patients. However, hyoscyamine may be administered if it is used to reduce adverse muscarinic effects of cholinesterase inhibitor. Hyoscyamine should be similarly used with extreme caution in patients with autonomic neuropathy. Hyoscyamine is contraindicated in patients with glaucoma. Mydriatic effect of hyoscyamine causes an increase in intraocular pressure, thereby potentially precipitating acute attack of glaucoma. Psychosis has been reported in sensitive individuals given anticholinergic drugs. Central nervous system signs and symptoms include confusion, disorientation, short term memory loss, hallucinations, dysarthria, ataxia, coma, euphoria, decreased anxiety, fatigue, insomnia, agitation and mannerisms, and inappropriate effects These CNS signs and symptoms usually resolve within 12 to 48 hours after discontinuation of the drug. Hyoscyamine causes tachycardia. Use cautiously in patients with unstable cardiac disease, especially cardiac arrhythmias, congestive heart failure, coronary artery disease, and mitral stenosis. Additionally, increases in heart rate may be undesirable in patients with hyperthyroidism or acute hemorrhage with unstable cardiovascular status. Like other anticholinergic agents, hyoscyamine may produce drowsiness, dizziness or blurred vision. In this event, patients should be warned not to engage in activities requiring mental alertness such as driving or operating machinery or performing hazardous work while taking this drug. The Anticholinergic effects of hyoscyamine may make eyes dry. This can cause increased lens awareness, or blurred vision for wearers of contact lenses. Use of hyoscyamine may decrease sweating, resulting in heat prostration or heat stroke; Patients with fever or those who may be exposed to elevated environmental temperatures should be careful Hyoscyamine can decrease gastric motility and tone. This can aggravate GI obstruction or ileus and / or exacerbate retention in patients with pyloroduodenal obstruction. Hyoscyamine should not be used in patients with GI obstruction, paralytic ileus, intestinal atony, severe ulcerative colitis, or toxic megacolon. Further, hyoscyamine should be administered with extreme caution in persons with suspected or known infectious diarrhea such as dysentery, gastroenteritis, or pseudomembranous colitis.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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