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Last Updated: 02 May 2022
inhibition of nf- κ b pathway and modulation of mapk signaling pathways in glioblastoma and implications for lovastatin and tumor necrosis factor-related apoptosis inducing ligand (trail) combination therapy "inhibition of nf- κ b pathway and modulation of mapk signaling pathways in glioblastoma and implications for lovastatin and tumor necrosis factor-related apoptosis inducing ligand (trail) combination therapy", by . pone.0171157.g004: Anti-tumor effect of lovastatin on glioblastoma animal model and induction of DR5 expression by peri-tumoral administration of lovastatin in nude mice.(A) The U87 MG cells were treated with different concentrations of lovastatin for 48...

Lovastatin is a cholesterol decreasing agent isolated from a stress of Aspergillus terreus. Lovastatin is [1 S- [1,3,7,8,8 a] -1,237 8,8a-hexahydro-3,7-dimethyl-8 [2-ethyl] -1 naphthalenyl 2-methylbutanoate. The empirical formula of lovastatin is C 24H 36O 5 and its molecular weight is 404. 55. Lovastatin tablets USP are provided as 10 mg, 20 mg and 40 mg tablets for oral administration. In enhancement to the active ingredient lovastatin, each tablet has the following inactive active ingredients: D&C Yellow No. 10 Aluminum Lake, FD&C Blue No. 2 Aluminum Lake, lactose anhydrous, lactose monohydrate, magnesium stearate, microcrystalline cellulose and pregelatinized corn starch. Once if you become pregnant, quit taking lovastatin and tell your medical professional at. Stop taking this medication and inform your medical professional simultaneously if you conceive. Even if you have no symptoms, tests can aid your medical professional determine if lovastatin is reliable. You might need to quit using lovastatin for a short time if you have surgical treatment or a medical emergency situation. Take the medication as quickly as you can, yet avoid the missed dose if it is nearly time for your following dose. This medicine may also aid protect against medical issues created by fat clogging the blood vessels. It might also be used to avoid specific types of heart and capillary troubles in patients with risk aspects for heart issues. Lovastatin comes from the group of medicines called HMG-CoA reductase preventions, or statins. It works to reduce the quantity of cholesterol in the blood by obstructing an enzyme that is required by the body to make cholesterol. This medicine is readily available only with your medical professional's prescription.

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PubChem - CovalentUnitCount

(Table source)
53232C24H36O5404.5CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)CCC[[email protected]](C)C(=O)O[[email protected]]1C[[email protected]](C=C2[[email protected]]1[[email protected]]([[email protected]](C=C2)C)CC[[email protected]@H]3C[[email protected]](CC(=O)O3)O)CInChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1PCZOHLXUXFIOCF-BXMDZJJMSA-N[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate4.3404.25627424404.2562742472.866601572908800001
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