Mal de Meleda is unusual skin disorder that starts in very early infancy. Affected people have a condition referred to as palmoplantar keratoderma, in which the skin of the palms of the hands and soles of the feet ends up being thick, hard, and callused. In mal de Meleda, the thickened skin is also found on the back of the feet and hands and on the wrists and ankles. Some people with mal de Meleda have recurrent fungal infections in the enlarged skin, which can lead to a solid smell.
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