Summarized by Plex Health
Last Updated: 02 May 2022
evidence for different mechanisms of 'unhooking' for melphalan and cisplatin-induced dna interstrand cross-links in vitro and in clinical acquired resistant tumour samples. "evidence for different mechanisms of 'unhooking' for melphalan and cisplatin-induced dna interstrand cross-links in vitro and in clinical acquired resistant tumour samples.", by Spanswick VJ, Lowe HL, Newton C, Bingham JP, Bagnobianchi A, Kiakos K, Craddock C, Ledermann JA, Hochhauser D, Hartley JA. F2: DNA ICL and γ-H2AXfoci formation in A549cells following treatment witheither cisplatin or melphalan.A: Representative comet images from A549 cells either untreated, or treated with 50 μM melphalan for 1 hour. Drug-treated samples shown were...

Melphalan, known as L-phenylalanine mustard, phenylalanine l-pam, mustard, or l-sarcolysin, is a phenylalanine by-product of nitrogen mustard. Melphalan is a bifunctional alkylating agent that is active against selected human neoplastic diseases. It is understood chemically as 4- [bisamino] - L-phenylalanine. The molecular formula is C 13H 18Cl 2N 2O 2 and the molecular weight is 305. 20. The structural formula is: Melphalan is the active L-isomer of the compound and was first manufactured in 1953 by Bergel and Stock; the D-isomer, called medphalan, is less active versus certain animal tumors, and the dosage required to generate impacts on chromosomes is larger than that called for with the L-isomer. The racemic kind is referred to as merphalan or sarcolysin. Melphalan is almost insoluble in water and has a pKa 1 of ~ 2. 5 Melphalan Hydrochloride for Injection is supplied as a sterilized, nonpyrogenic, white to off-white lyophilized cake or powder. Each single-use vial has melphalan hydrochloride matching to 50 mg melphalan and 20 mg povidone. Melphalan Hydrochloride for Injection is reconstituted using the sterilized diluent supplied. Each vial of sterilized diluent consists of salt citrate 0. 2 g, propylene glycol 6. 0 mL, ethanol 0. 52 mL, and Water for Injection to an overall of 10 mL. Melphalan Hydrochloride for Injection is carried out intravenously.

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PubChem - CovalentUnitCount

(Table source)
460612C13H18Cl2N2O2305.20C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCClC1=CC(=CC=C1C[[email protected]@H](C(=O)O)N)N(CCCl)CCClInChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1SGDBTWWWUNNDEQ-LBPRGKRZSA-N(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid-0.5304.0745332304.074533266.626502481901100001
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