Methotrexate

Summarized by Plex Health
Last Updated: 03 May 2022
methotrexate "methotrexate", by Unknown Photographer. Bottle of methotrexate. It is used to treat some types of cancer, rheumatoid arthritis, and severe skin conditions, such as psoriasis. Methotrexate stops cells from making DNA and may kill cancer cells. It is a...

Methotrexate is used to deal with forms of vasculitis which, although major, do not require therapy with cyclophosphamide. MTX often aids patients avoid cyclophosphamide and decreases patients' requirements for steroids. Specific forms of vasculitis treated with MTX include Wegener's granuloma t os is, Microscopic polyangiitis, Churg-Strauss syndrome, Behcet's disease, and others. At the Vasculitis Center, we suggest MTX when a patient's disease needs to be regulated or to keep a patient from relapsing. You require to recognize what you and your physicians should perform in order to check your problem while you get on MTX. We present our method to making use of MTX in a layout that consists of frequently asked concerns from Vasculitis Center patients. MTX works by dampening the inflammatory procedure connected with active vasculitis. The objective of utilizing MTX is to push the disease into remission as soon as possible, prior to the swelling causes permanent organ damages. Methotrexate is additionally used to deal with extreme psoriasis and rheumatoid arthritis in adults. Methotrexate is sometimes used to treat cancer while pregnant. Tell your physician if you are pregnant or strategy to conceive. Methotrexate can cause significant or deadly side effects. Methotrexate can damage an expected infant if the mom or the dad is using this medication. Do not offer this medication to a child without the recommendations of a physician. Your cancer therapies may be postponed based on the outcomes. Tell your dentist you presently use methotrexate if you require to be sedated for oral work. It is very essential that you take your medication as your doctor informs you. Your medication container may have several doses with guidelines for how to take once each week. Take the tablets on an empty stomach about one hr before a dish or 2 to 3 hours after a dish. Methotrexate oral fluid ought to be stored in the refrigerator. Absorbing large quantities of folic acid can decrease the cancer-fighting results of methotrexate. At least one week before you begin taking MTX, you need to stop taking multivitamins by mouth if they consist of folic acid. You need to not eat energy drinks, foods, and supplements that consist of 100 percent or more of the everyday value of folic acid while taking methotrexate.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
126941C20H22N8O5454.4CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)OCN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)OInChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1FBOZXECLQNJBKD-ZDUSSCGKSA-N(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid-1.8454.17131583454.17131583211704051293301100001
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