Metoclopramide

"effects of metoclopramide on esophageal motor activity and esophagogastric junction compliance in healthy volunteers.", by Mikami H, Ishimura N, Fukazawa K, Okada M, Izumi D, Shimura S, Okimoto E, Aimi M, Ishihara S, Kinoshita Y. f1-jnm-22-112: Esophageal motor activity with and without metoclopramide. Examination of a representative subject using high-resolution manometry. Esophageal peristaltic contractions (segments 1–3) and resting lower esophageal sphincter (LES) pressure were augmented after intravenous administration of metoclopramide....

Metoclopramide hydrochloride is a white crystalline, odor free substance, openly soluble in water. Chemically, it is 4-amino-5chloro-N [2-ethyl] -2 methoxy benzamide monohydrochloride monohydrate. Molecular weight: 354. 3 Metoclopramide Injection, USP is a clear, anemic, sterile service with a pH of 2. 5 to 6. 5 for intravenous or intramuscular administration. This item is light delicate. If either shade or particle is observed, it needs to be checked before use and disposed of. 2 mL single dose vials; 10 mL and 30 mL single dose vials. pH readjusted, when necessary, with hydrochloric acid and/or sodium hydroxide. Tell your doctor or pharmacologist if you: have had a sensitive response to metoclopramide or any other medicines in the past; have ever before had blood loss from your stomach or intestines; have kidney or liver issues; have a sluggish heart beat; have a tumor on your adrenal gland; have unusual inherited blood disorder such as porphyria, methaemoglobinemia, or NADH cytochrome-b5 deficiency; have ever had involuntary muscle mass spasms when taking medications such as metoclopramide or antipsychotics; have Parkinson's disease, or epilepsy, or a background of seizures or fits; are attempting to get pregnant, you're already pregnant or if you're nursing. Metoclopramide oral is used for 4 to 12 weeks to treat heartburn triggered by gastroesophageal reflux in people who have used other drugs without alleviation. Do not use this medication if you've ever had muscle mass movement troubles after using metoclopramide or comparable medicines, or if you've had a movement disorder called tardive dyskinesia. Metoclopramide might damage a coming infant if you use the medication during late maternity. High doses or long-lasting use metoclopramide can cause a severe movement disorder that may not be relatively easy to fix.

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