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Mmr Covid Protection

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Last Updated: 02 July 2021

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General | Latest Info

Friday, Sept. 4 2020 - New clinical trial will try to determine whether measles, mumps and Rubella Vaccine can protect health care workers from being infected with COVID - 19. Hundreds of millions of people have received MMR Vaccine since it was developed nearly 50 years ago. It's usually given to children before age 6. Growing evidence suggests that vaccines may also prevent COVID - 19. We know that MMR Vaccine is safe, and we think there are two main reasons that it could prevent COVID - 19, say researcher Dr. Michael Avidan, head of the Department of Anesthesiology at Washington University School of Medicine Louis. First is this vaccine includes small amounts of live but very weakened measles, mumps and Rubella viruses, Avidan explains in a University news release. This type of vaccine appears to strengthen the body's immune response to infections in general, not just to viruses in that particular vaccine. MMR Vaccine may also work because it protects against viruses that are similar to Coronavirus. Researchers think that antibodies made to MMR Vaccine might also fight SARS - CoV - 2. In addition, researchers hope that MMR Vaccine might make cases of COVID - 19 milder. The Trial is funded by a 9 million grant from the Bill and Melinda Gates Foundation, Wellcome Trust, Mastercard, and other public and philanthropic donors. Researchers hope to enroll as many as 30 000 health care workers around the world. Participants will be randomly selected to get MMR Vaccine or placebo. Most of those recruited for trial will receive booster,s as they likely receive vaccine as children. But in some countries where MMR Vaccine isn't widely give, health care workers may be receiving vaccine for the first time, researchers note. Countries involved in study include Canada, Ghana, Ireland, South Africa, Uganda, United Kingdom, United States, Zambia and Zimbabwe. Each study participant will be followed for five months, and the entire trial is expected to last about a year, researchers say. Scientists at University College London will compile data from the trial.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Training the immune system

The immune system fights off any foreign particles that enter the human body. Viral particles possess antigenic structures that respond through an adaptive immune system via antibody production. Antibodies are proteins that recognize invading pathogens by binding specifically to their surface antigenic proteins. This antibody - antigen binding is important for neutralizing and prevention of viral infections. So, viruses can be removed from the body by antibodies before they get a chance to infect cell. Production of antibodies can actively be induced via immunization. Humans are routinely immunized against several viral diseases like Measles, Rubella, mumps, hepatitis, hepatitis B, rotavirus, and poliomyelitis in early childhood. These immunizations usually induce broad immunity against viral particles, when live - attenuated whole viral particles are used in vaccines. We think that surface proteins of one or more of the above - mentioned viruses could share antigenic epitopes with Spike Glycoprotein of SARS - COV - 2. Therefore, general immunity of children against COVID - 19 could be related to antibodies that are produced through routine vaccination. Antibodies may then cross - react with antigenic epitopes of Spike Glycoprotein.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

The evidence behind the theory

Newswise Washington, DC - June 19 2020 - Administering MMR vaccine could serve as a preventive measure to dampen septic inflammation Associate with COVID - 19 infection, say a team of experts in this week's mBio, journal of American Society for Microbiology. Long - time collaborators and spouses Dr. Paul Fidel, Jr., Department Chair, Oral and Craniofacial Biology, and Associate Dean for Research, Louisiana State University Health School of Dentistry and Dr. Mairi Noverr, Professor of Microbiology & Immunology at Tulane University School of Medicine in New Orleans co - authored perspective article based on ideas stemming from Research in their labs. Vaccination with MMR in immunocompetent individuals has no contraindications and may be especially effective for health care workers WHO can easily be exposed to COVID - 19, say researchers. Live attenuated Vaccines seemingly have some nonspecific benefits as well as immunity to target pathogen.S Clinical trial with MMR in high - risk populations may provide low - risk - high - reward preventive measure in saving lives during the COVID - 19 pandemic, says Dr. Fidel. While we are conducting clinical trials, I don't think it's going to hurt anybody to have MMR vaccine that would protect against measles, mumps, and rubella with this potential add benefit of helping against COVID - 19. Mounting evidence demonstrates that live attenuated vaccines provide nonspecific protection against lethal infections unrelated to the target pathogen of the vaccine by inducing trained nonspecific innate immune cells to improve host responses against subsequent infections. Live attenuated Vaccines induce nonspecific effects representing trained innate immunity by training leukocyte precursors in bone marrow to function more effectively against broader infectious insults. In Dr. Noverr's laboratory, in collaboration with Dr. Fidel, vaccination with live attenuate fungal strain - induced trained innate protection against lethal polymicrobial sepsis. Protection was mediated by long - live myeloid - derive suppressor cells previously reported to inhibiting septic inflammation and mortality in several experimental models. Researchers say that the MMR vaccine should be able to induce MDSCs that can inhibit or reduce severe lung inflammation / sepsis Associate with COVID - 19. Mortality in COVID - 19 cases is strongly associated with progressive lung inflammation and eventual sepsis. Recent events provide support for researchers ' hypothesis. Milder symptoms seen in 955 sailors on USS Roosevelt WHO tested positive for COVID - 19 may have been a consequence of the fact that MMR vaccinations are given to all US Navy recruits. In addition, epidemiological data suggest a correlation between people in geographical locations WHO routinely receive MMR vaccine and reduced COVID - 19 death rates. Covid - 19 has not had a big impact on children, and researchers hypothesize that one reason children are protected against viral infections that induce sepsis is their more recent and more frequent exposures to live attenuated vaccines that can also induce trained suppressive MDSCs that limit inflammation and sepsis. Researchers propose clinical trial to test whether the MMR vaccine can protect against COVID - 19, but in the meantime, they suggest that all adults, especially health care workers and individuals in nursing homes, get the MMR vaccine.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Progressing to clinical trial

Covid - 19 is a disease caused by the novel betacoronavirus, severe acute respiratory Syndrome Coronavirus 2. The disease was first reported in December 2019 in Wuhan, China and the full genome was sequence and published by January 05 2020. By March 11 2020, COVID - 19 had spread globally and was declared pandemic, with, at time of writing, June 6 2020, there had been over 6 million people infected and 380 000 deaths. Diseases primarily affect respiratory tract and disease severity can range from very mild rhinorrhoea to severe acute respiratory distress Syndrome and death,. Non - respiratory symptoms such as anosmia, diarrhoea, rash, thromboembolic disorders, myocarditis and vasculitis have also been associated with COVID - 19,. The median incubation period is estimated to be 5 days with the majority developing symptoms by 11. 5 days. Covid - 19 patients have been shown to excrete viral nucleic acid at highest levels at onset of symptoms. This, and other epidemiological data suggest transmissibility within as yet undefined pre - symptomatic period. Clinical deterioration is usually delayed into the second week of illness and associated with laboratory features of immune - mediate cytokine storm causing widespread inflammation and disseminate intravascular coagulation, usually with low level viraemia,. The case fatality rate is consistently reported to be age dependent, with a higher percentage of elderly cases dying, although other factors are also associated with intensive care admission and mortality, including sex, hypertension, obesity and diabetes. Report case fatality rates have been between 0. 82% and 9. 64%, with variability in CFR likely due to testing frequency and access as well as other health system capacity factors in different locations. The Infection fatality rate is a better estimate of population mortality and is modelled to be between 0. 1% and 0. 41%. Sars - CoV - 2 is one of three coronaviruses that may cause severe respiratory diseases, including fatality, in humans and has been associated with major outbreaks in the last 20 years;. The other two viruses are severe acute respiratory Syndrome Coronavirus and Middle East respiratory Syndrome Coronavirus. Although there were some attempts at development of vaccines against SARS and MERS, including a small number of human Phase 1 clinical trials, there are no licenced vaccines for any Coronavirus as yet. In addition to these novel Epidemic viruses with zoonotic origins, there are four other endemic human coronaviruses in circulation, HCoV2 - 229E, - HKU1, - NL63 and - OC43 all predominantly causing mild symptoms of common cold.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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