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Mmr Vaccine And Coronavirus

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Last Updated: 02 July 2021

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General | Latest Info

Friday, Sept. 4 2020 - A new clinical trial will try to determine whether Measles, mumps and Rubella Vaccine can protect health care workers from being infected with COVID - 19. Hundreds of millions of people have received MMR Vaccine since it was developed nearly 50 years ago. It's usually given to children before age 6. Growing evidence suggests that vaccines may also prevent COVID - 19. We know that MMR Vaccine is safe, and we think there are two main reasons that it could prevent COVID - 19, say researcher Dr. Michael Avidan, head of the Department of Anesthesiology at Washington University School of Medicine Louis. First is this vaccine includes small amounts of live but very weakened Measles, mumps and Rubella viruses, Avidan explains in a University news release. This type of vaccine appears to strengthen the body's immune response to infections in general, not just to viruses in that particular vaccine. MMR Vaccine may also work because it protects against viruses that are similar to Coronavirus. Researchers think that antibodies made to MMR Vaccine might also fight SARS - CoV - 2. In addition, researchers hope that MMR Vaccine might make cases of COVID - 19 milder. The Trial is funded by a $9 million grant from the Bill and Melinda Gates Foundation, Wellcome Trust, Mastercard, and other public and philanthropic donors. Researchers hope to enroll as many as 30 000 health care workers around the world. Participants will be randomly selected to get MMR Vaccine or placebo. Most of those recruited for trial will receive booster,s as they likely received Vaccine as Children. But in some countries where MMR Vaccine isn't widely give, health care workers may be receiving vaccine for the first time, researchers note. Countries involved in study include Canada, Ghana, Ireland, South Africa, Uganda, United Kingdom, United States, Zambia and Zimbabwe. Each study participant will be followed for five months, and the entire trial is expected to last about a year, researchers say. Scientists at University College London will compile data from the trial.

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* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Training the immune system

The type of vaccines that have effect against unrelated infectious are called live attenuate vaccines. This means they contain real viruses or bacteria that scientists have weakened in the laboratory. Studies show that these vaccines protect against other infections by training the immune system in a non - specific way. This type of non - specific Immune response is the first line of defense against infection and is called innate Immune response. Live attenuated vaccines seemingly have some nonspecific benefits as well as immunity to target pathogen,s explains co - author of the new paper Dr. Paul Fidel, Jr., Associate Dean for Research at Louisiana State University Health School of Dentistry in New Orleans. Dr. Fidel, together with Dr. Mairi Noverr, Professor of Microbiology & Immunology at Tulane University School of Medicine in New Orleans, suggest that protection afforded by these vaccines is due to myeloid - derive suppressor cells, or MDSCs, type of Immune cell that come from bone marrow. Scientists have shown that these cells can reduce inflammation and mortality in mouse models of infection. In their own research, Drs. Fidel and Noverr have shown that vaccination with live - attenuate fungus may protect against sepsis thanks to MDSCs.


What is a vaccine?

Some of the first vaccines being tested in clinical trials introduce SARS - CoV - 2 spike proteins to the body in a fascinating way. Rather than injecting coronavirus spike proteins directly, vaccines deliver genetic instructions that make their way into shoulder - muscle cells near the injection site. One vaccine now being tested introduces genetic instructions to muscle cells in a tiny fatty envelope; another vaccine does so using weakened common - cold virus called adenovirus. Once in muscle cells, mRNA instructs those cells to produce coronavirus spike proteins that then trigger immune response. Other vaccine types used to spur immune response include DNA vaccines that introduce DNA to induce human cells to churn out virus proteins; inactivate and live attenuate vaccines that use inactive or weakened forms of target virus; and vaccines that directly introduce viral proteins or protein fragments.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

The evidence behind the theory

In a video that has exploded on social media in the past few days, virologist Judy Mikovits claims the New Coronavirus is being wrongly blamed for many deaths. She makes head - scratching assertions about software, instance, that it is activated by face masks. Mikovits also accuse Anthony Fauci, head of the US National Institute of Allergy and Infectious Diseases and prominent member of the White House Coronavirus Task Force, of being responsible for the deaths of millions during the early years of the HIV / AIDS pandemic. The video claims Mikovits was part of a team that discovered HIV, revolutionized HIV treatment, and was jailed without charges for her scientific positions. Science fact - checked the video. None of these claims are true. The video is an excerpt from the forthcoming movie Plandemic, which Promise to expose the scientific and political elite WHO run scam that is our Global Health system. Youtube, Facebook, and other platforms have taken down videos because of inaccuracies. It keeps resurfacing, including on the Plandemic website, which, in an effort to bypass gatekeepers of free speech, invites people to download video and repost it. Mikovits started her career as a lab technician at the National Cancer Institute in 1988. She became a scientist and obtained ph. D in biochemistry and molecular biology from George Washington University in 1991. By 2009, she was Research director at Whittemore Peterson Institute, private Research center in Reno, Nevada, but she remains largely unknown to the scientific community. That year, however, she co an - authored a paper in Science that suggested an obscure agent named xenotropic murine leukemia virus - related virus cause chronic fatigue syndrome. The cause of CFS, also called allergic encephalomyelitis, had long remained elusive, and the disease had been neglected by Science. Study create hope that CFS might become treatable with antivirals. Some patients even begin to take antiretroviral drugs used by HIV - infected people. But paper also creates worries that XMRV might spread via blood supply. Other researchers soon questioned the findings, and over the next 2 years, paper claims fell apart. Researchers show that XMRV was created accidentally in the lab during mouse experiments; it may never have infected any humans. Authors first retract two figures and a table from paper in October 2011. Around the same time, studies by several labs, including WPI itself, showed findings could be replicate. Two months later, entire Science paper was retract. Mikovits refused to sign a retraction notice, but she took part in another major replication effort. That $2. 3 million study, led by Ian Lipkin of Columbia University and funded by the National Institutes of Health, was the definitive answer, Mikovits said at a September 2012 press conference where results were announce. A rigorous study looked for XMRV in blinded blood samples from nearly 300 people, half of whom had the disease, and none had the virus. There is no evidence that XMRV is a human pathogen, Mikovits concede.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Progressing to clinical trial

Table2

DEVELOPER(S)VACCINE METHODEVIDENCESTATUS
Multiple organizations InternationalThe Bacille Calmette-Guerin (BCG) vaccine for tuberculosis consists of live attenuated Mycobacterium bovis .Lower rates of COVID-19-related deaths in countries with mandatory BCG vaccination prompted the launch of several clinical trials to test whether the immune response triggered by the vaccine may protect against SARS-CoV-2.Several Phase 3 and 4 trials are underway .
Multiple organizations InternationalThe measles-mumps-rubella (MMR) vaccine consists of live-attenuated strains of the three viruses.Epidemiological data have revealed that places where the MMR vaccine is given as standard medical care have lower COVID-19 death rates than areas where MMR vaccination is not standard. Additionally, sailors aboard the U . S . S . Roosevelt who tested positive for COVID-19 had mostly mild symptoms, which some researchers suspect may have been due to administration of the MMR vaccine to all US Navy recruits.A Phase 3 trial is underway in Egypt, led by researchers at Kasr El Aini Hospital. Separately, researchers at the Washington University School of Medicine are running an international Phase 3 trial of healthcare workers in the US, Canada, Europe, and Africa.
Immunovative Therapies, Mirror Biologics USAn off-the-shelf living immune cellThe affiliated companies are currently testing the formulation as a therapeutic vaccine for chemotherapy-refractory metastatic cancers .A Phase 1/2 trial for healthy older adults has been approved to begin in New York.
Canadian Cancer Trials Group, others Can adaHeat-killed Mycobacterium obuenseThe vaccine is intended to stimulate nonspecific innate immunity. The company is also testing the vaccine in clinical trials for cancer .A Phase 3 trial has been approved to begin in Canada .
Bandim Health Project Guinea-BissauOral polio vaccine, an attenuated strain of the poliovirusResearchers argue that the vaccine is safer and available in greater quantities than the BCG vaccine against tuberculosis, which is also being tested as a possible COVID-19 preventive.A Phase 4 trial has been approved to begin in Guinea-Bissau in West Africa.
Inmunotek, BioClever Mexi coA mixture of inactivated bacteriaThe vaccine is intended to stimulate nonspecific innate immunity.A Phase 3 trial for healthcare workers has been approved to begin in Mexico.
Pulmotect USAn inhaled combination of two synthetic Toll-like receptor agonistsThe vaccine was originally developed as a potential therapeutic for cancer and has undergone early stage clinical testing. In mice, it provided protection against a range of respiratory pathogens, including MERS and SARS.A Phase 2 trial for people with known SARS-CoV-2 exposure is underway in several US states.

Covid - 19 is a disease caused by the novel betacoronavirus, severe acute respiratory Syndrome Coronavirus 2. The disease was first reported in December 2019 in Wuhan, CHINA and the full genome was sequence and published by January 05 2020. By March 11 2020, COVID - 19 had spread globally and was declared pandemic, with, at time of writing, June 6 2020, there had been over 6 million people infected and 380 000 deaths. Diseases primarily affect respiratory tract and disease severity can range from very mild rhinorrhoea to severe acute respiratory distress Syndrome and death,. Non - respiratory symptoms such as anosmia, diarrhoea, rash, thromboembolic disorders, myocarditis and vasculitis have also been associated with COVID - 19,. The median incubation period is estimated to be 5 days with the majority developing symptoms by 11. 5 days. Covid - 19 patients have been shown to excrete viral nucleic acid at highest levels at onset of symptoms. This, and other epidemiological data suggest transmissibility within as yet undefined pre - symptomatic period. Clinical deterioration is usually delayed into the second week of illness and associated with laboratory features of immune - mediate cytokine storm causing widespread inflammation and disseminate intravascular coagulation, usually with low level viraemia,. The case fatality rate is consistently reported to be age dependent, with a higher percentage of elderly cases dying, although other factors are also associated with intensive care admission and mortality, including sex, hypertension, obesity and diabetes. Report case fatality rates have been between 0. 82% and 9. 64%, with variability in CFR likely due to TESTING frequency and access as well as other health system capacity factors in different locations. The Infection fatality rate is a better estimate of population mortality and is modelled to be between 0. 1% and 0. 41%. Sars - CoV - 2 is one of three coronaviruses that may cause severe respiratory diseases, including fatality, in humans and has been associated with major outbreaks in the last 20 years;. The other two viruses are severe acute respiratory Syndrome Coronavirus and Middle East respiratory Syndrome Coronavirus. Although there were some attempts at development of Vaccines against SARS and MERS, including a small number of human PHASE 1 clinical TRIALS, there are no licenced Vaccines FOR any Coronavirus as yet. In addition to these novel Epidemic viruses with zoonotic origins, there are four other endemic human coronaviruses in circulation, HCoV2 - 229E, - HKU1, - NL63 and - OC43 all predominantly causing mild symptoms of common cold.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Abbreviations

The Centers for Disease Control and Prevention advisory Committee on Immunization Practices provides a list of standardized abbreviations or acronyms for FDA - approved Vaccines. The list includes most single and combination vaccines but not all. The list was developed by CDC; ACIP Work Groups and members; editors of Morbidity and Mortality Weekly Report and Epidemiology and Prevention of Vaccine - Preventable Diseases; and liaison organizations to ACIP. According to CDC, abbreviations and acronyms are intended to provide a uniform approach for referencing Vaccines in ACIP recommendations that are published in MMWR, Pink Book, American Academy of Pediatrics Red Book, and US Immunization schedules for Children, adolescents, and adults. Cdc believes this list will promote accuracy, consistency, and convenience, and will reduce errors and ambiguity in Vaccine labeling, medical practice, and scientific publications. However, preamble to list on the CDC website only suggests that standard abbreviations are intended for use in ACIP recommendations published in various references and Immunization schedules. Healthcare practitioners are not specifically encouraged in preamble to use standard abbreviations when prescribing immunizations or documenting administration on immunization record. The Cdc site also includes a list of abbreviations that are often used on Immunization records, including abbreviations for Vaccine - target Diseases and old or non - standard abbreviations. This resource is helpful to those attempting to translate the myriad of abbreviations often found on patient immunization records, and there is an open invitation below to contact the web team directly to let the agency know if it is missing an abbreviation or acronym found on health record.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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