Mood Disorders

"chronic unpredictable stress (cus)-induced anxiety and related mood disorders in a zebrafish model: altered brain proteome profile implicates mitochondrial dysfunction.", by Chakravarty S, Reddy BR, Sudhakar SR, Saxena S, Das T, Meghah V, Brahmendra Swamy CV, Kumar A, Idris MM. pone-0063302-g002: CUS in zebrafish mimics established molecular markers of rodent mood disorder models and attenuates adult neurogenesis.Effects of the 15-day chronic unpredictable stress (CUS) protocol on the levels of CRF, ppp3r1a (calcineurin) and BDNF, which...

When you think of mood disorders, clinical depression and bipolar disorder likely come to mind. Clinical depression and bipolar illness can be mentally debilitating, making it challenging to live life to its maximum. Persistent Depressive Disorder, a newer medical diagnosis that combines chronic significant depressive disorder and dysthymic disorder, is a condition where a person is depressed for a minimum of 2 years. Relentless Depressive Disorder is a less extreme type of anxiety. Less severe, Persistent Depressive Disorder causes chronic or durable grumpiness that ranges in seriousness. In children and teens, moods can be cranky for a minimum of 1 year to be called Persistent Depressive Disorder. PDD can occur alone or with other psychiatric or mood disorders, although not with mania or hypomania. Just like anxiety, PDD is more common in women than in men. A family history of mood disorders is not unusual. This mood disorder has a tendency to show up earlier than major anxiety, although it can start anytime from childhood to later in life. In addition to chronic low moods, common symptoms of this mood disorder include: Feelings of hopelessness or helplessness; Trouble resting or daytime drowsiness; Poor appetite or consuming too much; Poor concentration; Fatigue or low energy; Low self-confidence; Trouble focusing or making choices. A diagnosis of PDD in adults calls for a minimum of a two-year background of depressed mood for the majority of the day on most days, in addition to at least two of the symptoms noted over. Although some symptoms might overlap, you might be less likely to carry weight or rest changes with PDD than with anxiety.

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