Moxetumomab Pasudotox
Summarized by Plex Health
Last Updated: 04 May 2022
Moxetumomab pasudotox-tdfk is made up of a recombinant, murine immunoglobulin variable domain genetically integrated to a truncated type of Pseudomonas exotoxin, PE38, that hinders protein synthesis. Moxetumomab pasudotox-tdfk has an approximate molecular weight of 63 kDa and is produced in E. coli cells by recombinant DNA modern technology. LUMOXITI for shot is supplied as a sterile, preservative-free, white to beige lyophilized cake or powder in a single-dose vial for reconstitution and dilution before intravenous mixture. After reconstitution with 1. 1 mL Sterile Water for Injection, USP, the resulting 1 mg/mL option allows a withdrawal volume of 1 mL. Prior to intravenous mixture, the reconstituted vial of remedy are included in an infusion bag having 50 mL of 0. 9% Sodium Chloride Injection, USP and 1 mL of IV Solution Stabilizer. IV Solution Stabilizer is a sterile, preservative-free, anemic to slightly yellow, clear remedy devoid of visible bits and supplied in a single-dose vial. The LUMOXITI and IV Solution Stabilizer vial stoppers are not made with natural rubber latex.
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Sources:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d6510282-1a57-4614-9859-299a227a0...
Research Papers' Summaries
PubChem - CovalentUnitCount
(Table source)| CID | MolecularFormula | MolecularWeight | CanonicalSMILES | IsomericSMILES | InChI | InChIKey | IUPACName | XLogP | ExactMass | MonoisotopicMass | TPSA | Complexity | Charge | HBondDonorCount | HBondAcceptorCount | RotatableBondCount | HeavyAtomCount | IsotopeAtomCount | AtomStereoCount | DefinedAtomStereoCount | UndefinedAtomStereoCount | BondStereoCount | DefinedBondStereoCount | UndefinedBondStereoCount | CovalentUnitCount |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 135350821 | C33H49N5O4S | 611.8 | CCC(=O)NC(CC1=NC2=C(S1)C=C(C=C2)C(C)C)C(=O)NC(CNC(=O)C(=C)CCN3CCOCC3)C4CCCCC4 | CCC(=O)NC(CC1=NC2=C(S1)C=C(C=C2)C(C)C)C(=O)NC(CNC(=O)C(=C)CCN3CCOCC3)C4CCCCC4 | InChI=1S/C33H49N5O4S/c1-5-30(39)35-27(20-31-36-26-12-11-25(22(2)3)19-29(26)43-31)33(41)37-28(24-9-7-6-8-10-24)21-34-32(40)23(4)13-14-38-15-17-42-18-16-38/h11-12,19,22,24,27-28H,4-10,13-18,20-21H2,1-3H3,(H,34,40)(H,35,39)(H,37,41) | INAMQTHRAHVNST-UHFFFAOYSA-N | N-[2-cyclohexyl-2-[[2-(propanoylamino)-3-(6-propan-2-yl-1,3-benzothiazol-2-yl)propanoyl]amino]ethyl]-2-methylidene-4-morpholin-4-ylbutanamide | 5.2 | 611.35052623 | 611.35052623 | 141 | 936 | 0 | 3 | 7 | 14 | 43 | 0 | 2 | 0 | 2 | 0 | 0 | 0 | 1 |
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