Multiple Endocrine Neoplasia

Summarized by Plex Health
Last Updated: 02 May 2022

Multiple endocrine neoplasia is a group of disorders that influence the body's network of hormone-producing glands called the endocrine system. Multiple endocrine neoplasia commonly includes tumors in at least 2 endocrine glands; tumors can additionally develop in other body organs and tissues. The most common sign of multiple endocrine neoplasia type 1 is overactivity of the parathyroid glands. One of the most common sign of multiple endocrine neoplasia type 2 is a type of thyroid cancer called medullary thyroid carcinoma. Some people with this disorder also develop a pheochromocytoma, which is an adrenal gland tumor that can cause dangerously high blood pressure. Multiple endocrine neoplasia type 2 is split into three subtypes: type 2A, type 2B, and familial medullary thyroid carcinoma. The signs and symptoms of multiple endocrine neoplasia type 2 are reasonably consistent within any one family. Multiple endocrine neoplasia type 4 appears to have signs and symptoms similar to those of type 1, although it is triggered by mutations in a various genetics.

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