Naloxone

Summarized by Plex Health
Last Updated: 08 May 2022
comparative usability study of a novel auto-injector and an intranasal system for naloxone delivery. "comparative usability study of a novel auto-injector and an intranasal system for naloxone delivery.", by Edwards ET, Edwards ES, Davis E, Mulcare M, Wiklund M, Kelley G. Fig1: Naloxone nasal atomization kit (LMA® MAD Nasal™; Teleflex Inc., Morrisville, NC, USA) components and packaging. In descending order: Outer packaging for naloxone and delivery syringe (top); plastic delivery syringe; glass vial of naloxone hydrochloride;...

Naloxone is a drug authorized by the Food and Drug Administration designed to quickly reverse opioid overdose. Administered when a patient is showing signs of opioid overdose, naloxone is a short-term therapy and its effects do not last lengthy. A specialist should analyze the need to recommend naloxone for patients that are obtaining medication-assisted therapy or otherwise considered a risk for opioid overdose. Candidates for naloxone are those who: Take high dosages of opioids for lasting management of chronic pain; Receive revolving opioid drug regimens; Have been released from emergency clinical treatment adhering to opioid poisoning or drunkenness; Take particular extended-release or long-acting opioid drug; Those who have had a period of abstaining to consist of those lately released from incarceration. Pregnant women can be securely provided naloxone in limited doses under the supervision of a physician. It is essential to bear in mind to replace drug when the expiry day passes and if revealed to temperatures below 39 F or above 104 F.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
5284596C19H21NO4327.4C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)OC=CCN1CC[[email protected]]23[[email protected]@H]4C(=O)CC[[email protected]]2([[email protected]]1CC5=C3C(=C(C=C5)O)O4)OInChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1UZHSEJADLWPNLE-GRGSLBFTSA-N(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one2.1327.14705815327.147058157059402522404400001
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