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Naltrexone

Summarized by Plex Health
Last Updated: 02 May 2022
ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats. "ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats.", by Mattioli TA, Milne B, Cahill CM. F2: Intensity of astrocyte labelling in the dorsal lumbar spinal cord of rats. (A) Representative photomicrographs acquired by confocal microscopy of spinal cord sections labelled for the astrocytic protein, glial fibrillary acidic protein (GFAP). Spinal...

Intramuscular prolonged release Naltrexone is a drug authorized by the Food and Drug Administration to treat both Opioid Use Disorder and Alcohol Use Disorder as a Medication-Assisted Treatment option. Naltrexone can be suggested and provided by any expert accredited to prescribe medications, and is offered in a pill kind for Alcohol Use disorder or as an extended-release intramuscular injectable for Alcohol and Opioid Use disorder. Naltrexone is not a suggested MAT option for any individual more youthful than 18 years old, or for patients experiencing other wellness problems. To lower the risk of withdrawal symptoms created by OUD, patients should wait at least 7 days after their last use short-acting opioids and 10 to 14 days for long-acting opioids, prior to beginning naltrexone. Patients taking naltrexone needs to not use any other opioids or immoral drugs; drink alcohol; or take sedatives, tranquilizers, or other drugs. The medicine is not a cure for addiction. Naltrexone is not a narcotic. It works by obstructing the results of narcotics, particularly the "high' feeling that makes you intend to use them. Naltrexone will cause withdrawal symptoms in people who are physically reliant on narcotics. The size of time this takes might depend on which narcotic you took, the amount you took, and the length of time you took it. Prior to you start taking this medicine, make sure to inform your physician if you think you are still having withdrawal symptoms. This medicine is offered only with your physician's prescription. Utilizing these medicines in the 7 to 14 days before beginning naltrexone can cause unexpected opioid withdrawal symptoms. After getting naltrexone, your body will be more sensitive to opioids if you use an opioid medication in the future. It is not recognized whether naltrexone will harm an expected infant. If you use opioid medication while you are pregnant, your infant can end up being dependent on the medication. Children born dependent on opioids may need clinical therapy for a number of weeks. Naltrexone injections are only part of a full therapy program that may consist of added forms of therapy and/or surveillance.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
5360515C20H23NO4341.4C1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)O)O5)OC1CC1CN2CC[[email protected]]34[[email protected]@H]5C(=O)CC[[email protected]]3([[email protected]]2CC6=C4C(=C(C=C6)O)O5)OInChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1DQCKKXVULJGBQN-XFWGSAIBSA-N(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one1.9341.16270821341.162708217062102522504400001
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