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Neratinib

Summarized by Plex Health
Last Updated: 02 May 2022

Neratinib is used alone or with other medicines to deal with early-stage HER2-positive breast cancer. Neratinib is used to treat HER2-positive breast cancer that is advanced or has spread to other components of the body. Neratinib is used for breast cancer only if your tumor tests positive for a protein called human skin development variable receptor 2. HER2 protein can speed the development of cancer cells. Neratinib is provided after you have received particular other cancer medicines. Neratinib might be used for purposes not detailed in this medication overview. You might be given anti-diarrhea medicines for the first 2 months of treatment with neratinib. If the mommy or the father is making use of neratinib, Neratinib can cause or hurt unborn infant birth defects. You may require to take this medicine daily for up to one year. Neratinib is occasionally taken daily in 21-day treatment cycles up until the medication quits working or up until you have severe side effects. For the first 2 months of therapy with neratinib, you may require to take medicine to prevent or promptly treat diarrhea. Your doctor may advise you have an anti-diarrhea medicine such as loperamide readily available in any way times while you are taking neratinib. Take the anti-diarrhea medicine specifically as suggested by your doctor. Get aware of the checklist of foods you need to prevent or eat to help regulate diarrhea. If you have more than 2 bowel activities in 1 day, inform your doctor. Avoid the missed dose and use your following dosage at the routine time.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
9915743C30H29ClN6O3557.0CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)CCCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/CN(C)CInChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+JWNPDZNEKVCWMY-VQHVLOKHSA-N(E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide4.9556.1989665556.1989665112881028114000001101
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