Summarized by Plex Health
Last Updated: 02 May 2022
palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-jun/cox-2 signaling pathway. "palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-jun/cox-2 signaling pathway.", by Qin G, Xu F, Qin T, Zheng Q, Shi D, Xia W, Tian Y, Tang Y, Wang J, Xiao X, Deng W, Wang S. F2: Palbociclib inhibited breast cancer cell migration and invasion by suppressing vimentin and SnailA. MDA-MB-231 and T47D cells were treated with DMSO (control) or 7.5 μM or 15 μM palbociclib for 48 h after scratching....

Palbociclib is an oral medicine that is used to deal with specific types of breast cancer in adults. When taking palbociclib and might cause significant infections that can lead to fatality, low white blood cell matters are very common. Your doctor must examine your white blood cell matters previously and during therapy. If you develop low leukocyte counts throughout treatment, your health care provider might stop your therapy, decrease your dose, or may tell you to wait to start your therapy cycle. Palbociclib might cause serious side effects. Palbociclib is also being examined in the treatment of other types of cancer. Interpretation from the NCI Drug Dictionary, Detailed scientific meaning and other names for this medicine. Drugs are often examined to figure out if they can aid deal with or prevent problems apart from the ones they are approved for. This patient info sheet applies only to accepted uses the drug. Much of the info might additionally use to unauthorized uses that are being researched. Speculative Medulloblastoma Treatment Gets a Boost with Nanoparticles. Targeted Cancer Therapies. The molecular formula for palbociclib is C24H29N7O2. The chemical name is 6-acetyl-8cyclopentyl-5methyl-2 [5-pyridin-2yl] aminopyrido [2,3-d] pyrimidin-7one, and its structural formula is: Palbociclib is a yellow to orange powder with pKa of 7. 4 and 3. 9. At or below pH 4, palbociclib behaves as a high-solubility compound. Over pH 4, the solubility of the drug substance minimizes substantially. The light orange, light orange/caramel, and caramel opaque pill coverings consist of jelly, red iron oxide, yellow iron oxide, and titanium dioxide; the printing ink contains shellac, titanium dioxide, ammonium hydroxide, propylene glycol, and simethicone.

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