Palifermin
Summarized by Plex Health
Last Updated: 02 May 2022
-for-the-treatment-of-caustic-esophageal-burns.png "efficacy of keratinocyte growth factor (palifermin) for the treatment of caustic esophageal burns.")
"efficacy of keratinocyte growth factor (palifermin) for the treatment of caustic esophageal burns.", by Numanoğlu KV, Tatli D, Bektaş S, Er E. f3-etm-08-04-1087: Regular mucosal, submucosal and muscular structures were observed in the palifermin-treated group. A slight increase in collagen accumulation was observed in the muscularis mucosa (magnification, ×100; staining, hematoxylin-eosin and Masson’s trichrome)....
Palifermin is used to aid recover or protect against mouth sores and abscess in people being treated with chemotherapy and stem cell treatment. Palifermin is used in people receiving radiation treatment to deal with blood cancers. palifermin is not a therapy for the cancer itself. Palifermin may also be used for purposes not listed in this drug overview. Inform each of your healthcare providers about all your medical problems, allergic reactions, and all medications you use. Palifermin might cause growth in tumors that are not associated to a blood cancer. If you have a background of any type of tumor, talk to your medical professional. Palifermin may hurt unborn infant. Use effective contraception to protect against pregnancy, and inform your doctor if you conceive. palifermin may impact fertility, whether you are a man or a woman. A doctor will give you this injection prior to and after your chemotherapy treatment. Palifermin ought to not be given within 24 hrs prior to you obtain your chemotherapy.
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Research Papers' Summaries
PubChem - CovalentUnitCount
(Table source)| CID | MolecularFormula | MolecularWeight | CanonicalSMILES | IsomericSMILES | InChI | InChIKey | IUPACName | XLogP | ExactMass | MonoisotopicMass | TPSA | Complexity | Charge | HBondDonorCount | HBondAcceptorCount | RotatableBondCount | HeavyAtomCount | IsotopeAtomCount | AtomStereoCount | DefinedAtomStereoCount | UndefinedAtomStereoCount | BondStereoCount | DefinedBondStereoCount | UndefinedBondStereoCount | CovalentUnitCount |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 135252604 | C44H30N6 | 642.7 | C1=CC=C(C=C1)C2=NC(=NC(=N2)C3=CC=C(C=C3)N4C5=C(C=C(C=C5)N(C6=CC=CC=C6)C7=CC=CC=C7)C8=C4N=CC=C8)C9=CC=CC=C9 | C1=CC=C(C=C1)C2=NC(=NC(=N2)C3=CC=C(C=C3)N4C5=C(C=C(C=C5)N(C6=CC=CC=C6)C7=CC=CC=C7)C8=C4N=CC=C8)C9=CC=CC=C9 | InChI=1S/C44H30N6/c1-5-14-31(15-6-1)41-46-42(32-16-7-2-8-17-32)48-43(47-41)33-23-25-36(26-24-33)50-40-28-27-37(30-39(40)38-22-13-29-45-44(38)50)49(34-18-9-3-10-19-34)35-20-11-4-12-21-35/h1-30H | JBKCTKNWQIVOFC-UHFFFAOYSA-N | 9-[4-(4,6-diphenyl-1,3,5-triazin-2-yl)phenyl]-N,N-diphenylpyrido[2,3-b]indol-6-amine | 10.5 | 642.25319498 | 642.25319498 | 59.7 | 993 | 0 | 0 | 5 | 7 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
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