Panobinostat

Summarized by Plex Health
Last Updated: 02 May 2022
combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia. "combining the differentiating effect of panobinostat with the apoptotic effect of arsenic trioxide leads to significant survival benefit in a model of t(8;21) acute myeloid leukemia.", by Salmon JM, Bots M, Vidacs E, Stanley KL, Atadja P, Zuber J, Johnstone RW. Fig2: The combined effects of panobinostat and arsenic trioxide (ATO) include the differentiation ofA/E9a;NrasG12D-leukemic blasts by panobinostat and induction of apoptosis by ATO. (A) Flow cytometry analysis of the cell surface expression of c-Kit; Sca1;...

Panobinostat is used in combination with other drugs to treat numerous myeloma in adults who have obtained at least two other types of therapy. Panobinostat might also be used for functions not listed in this medicine overview. Panobinostat can cause fatal or major heart problems. Call your physician if you have serious diarrhea or stomach aches, or if you get dried out. Tell your doctor right away if you have any bleeding that will not quit, blood in your urine or stools, wooziness, complication, coughing or vomiting up blood. Panobinostat can hurt a coming child if the papa or the mom is making use of panobinostat. Comply with all directions on your prescription tag and read all drug overviews or instruction sheets. Your medical professional may occasionally change your dosage. Panobinostat is usually taken 3 times per week up until your doctor informs you to quit the medication. Take with a full glass of water at the same time of day, with or without food. If the medicine from a damaged pill enters your eyes or on your skin, wash your skin with soap and water or rinse your eyes with water. Do not take another capsule if you throw up soon after taking panobinostat. Panobinostat can cause serious diarrhea or dehydration. Use these medications for as long as your physician has prescribed. Store the blister pack inside the initial carton at room temperature level, away from light, moisture, and warm. Eliminate a capsule only when you prepare to take it. Use the medication as soon as you can, but skip the missed dose if you are greater than 12 hours late for the dosage.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
6918837C21H23N3O2349.4CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NOCC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NOInChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+FPOHNWQLNRZRFC-ZHACJKMWSA-N(E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide3349.17902698349.1790269877.247404372600001101
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