Parkinson’s disease

Summarized by Plex Health
Last Updated: 05 May 2022

Parkinson's disease is a brain disorder that causes unexpected or unmanageable activities, such as trembling, rigidity, and trouble with balance and coordination. As the disease proceeds, people might have difficulty speaking and strolling. While virtually anyone might be in danger for developing Parkinson's, some research studies recommend this disease influences more men than women. One clear risk is age: Although most individuals with Parkinson's first develop the disease after age 60, about 5% to 10% experience onset prior to the age of 50. The most prominent symptoms and signs of Parkinson's disease occur when nerve cells in the basal ganglia, an area of the brain that manages movement, end up being damaged and/or die. People with Parkinson's disease also lose the nerve endings that produce norepinephrine, the major chemical messenger of the supportive nerve system, which manages many functions of the body, such as heart rate and blood pressure. The loss of norepinephrine may help explain several of the non-movement features of Parkinson's, such as exhaustion, irregular high blood pressure, decreased movement of food with the digestion tract, and abrupt drop in high blood pressure when an individual stands from a resting or lying position. Many brain cells of people with Parkinson's disease consist of Lewy bodies, unusual globs of the protein alpha-synuclein. Researchers are trying to better comprehend the normal and abnormal functions of alpha-synuclein and its relationship to genetic mutations that impact Parkinson's and Lewy body dementia. Some cases of Parkinson's disease show up to be hereditary, and a couple of cases can be mapped to specific hereditary mutations.

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