Pilocarpine
Summarized by Plex Health
Last Updated: 02 May 2022
"detrimental effect of post status epilepticus treatment with rock inhibitor y-27632 in a pilocarpine model of temporal lobe epilepsy.", by Kourdougli N, Varpula S, Chazal G, Rivera C. F4: Y-27632 treatment during epileptogenesis alters KCC2 expression in the CA3 region. (A) Immunohistochemical stainings with KCC2 antibody (red) and NeuN (green) in the CA3 region of control vehicle- (A1,3) and Y-27632-treated animals (A2,4). The...
Pilocarpine tablets are used to treat dryness of the mouth and throat triggered by a decrease in the amount of saliva that may occur after radiation therapy for cancer of the head and neck or in patients with Sjogren's syndrome. This medication may assist you talk without needing to sip fluids. Pilocarpine may also be used to deal with dry skin of the eyes triggered by Sjogren's syndrome.
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Sources:
https://www.mayoclinic.org/drugs-supplements/pilocarpine-oral-route/description/drg-200654...
Research Papers' Summaries
PubChem - CovalentUnitCount
(Table source)| CID | MolecularFormula | MolecularWeight | CanonicalSMILES | IsomericSMILES | InChI | InChIKey | IUPACName | XLogP | ExactMass | MonoisotopicMass | TPSA | Complexity | Charge | HBondDonorCount | HBondAcceptorCount | RotatableBondCount | HeavyAtomCount | IsotopeAtomCount | AtomStereoCount | DefinedAtomStereoCount | UndefinedAtomStereoCount | BondStereoCount | DefinedBondStereoCount | UndefinedBondStereoCount | CovalentUnitCount |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5910 | C11H16N2O2 | 208.26 | CCC1C(COC1=O)CC2=CN=CN2C | CC[[email protected]]1[[email protected]](COC1=O)CC2=CN=CN2C | InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 | QCHFTSOMWOSFHM-WPRPVWTQSA-N | (3S,4R)-3-ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one | 1.1 | 208.121177757 | 208.121177757 | 44.1 | 245 | 0 | 0 | 3 | 3 | 15 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 1 |
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