Pityriasis Lichenoides

Summarized by Plex Health
Last Updated: 04 May 2022
pityriasis lichenoides chronica – like drug eruption developing during pembrolizumab treatment for metastatic melanoma "pityriasis lichenoides chronica – like drug eruption developing during pembrolizumab treatment for metastatic melanoma", by . fig1: A and B, Pityriasis lichenoides chronica–like drug eruption. The lower legs show several, 3- to 4-mm, red-brown, thin papules with centrally adherent micaceous scale and intermixed erosions....

Pityriasis lichenoides is a skin condition defined by small, raised pink areas that tend to come together in groups. There are two main types of PL: a severe form called pityriasis lichenoides et varioliformis acuta, and a milder, longer-lasting form called pityriasis lichenoides chronica. There is additionally unusual, serious variant of PLEVA called febrile ulceronecrotic PLEVA, connected with high fever and complications that may influence other body systems. PLEVA begins suddenly and may cause shedding or itching. PLC might develop over days, is less annoying, and lasts longer than PLEVA. Areas related to PLC generally discolor within 3 to 4 weeks, yet new areas may after that show up. Therapy alternatives may include antibiotics, phototherapy, PUVA, or drugs that reduce the immune system response in serious cases. The precise root cause of pityriasis lichenoides continues to be unidentified. The most typically reported connected infections in people with PL are Epstein-Barr virus, Toxoplasma gondii, and human immunodeficiency virus. Other infections that have been related to PL include cytomegalovirus, parvovirus, Staphylococcus aureus, and group A beta-haemolytic streptococci. Most cases of pityriasis lichenoides often tend to resolve by themselves gradually. First therapy for PL usually contains topical or systemic corticosteroids, or oral prescription antibiotics. A combination of tablets referred to as Psoralens with UVA may additionally be practical, yet brings a higher risk of side effects. Extreme forms of the disease may be handled by drugs that reduce the immune response. Info about specific drugs that may be used to treat PL is available on Medscape Reference's site below.

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