Plaquenil

Summarized by Plex Health
Last Updated: 04 May 2022

Plaquenil is used to avoid or treat malaria, a disease triggered by bloodsuckers that enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil can cause hazardous results on your heart, specifically if you additionally use specific other medications consisting of the antibiotic azithromycin. Taking Plaquenil long-lasting or at high dosages may cause permanent damage to the retina of your eye that could proceed to permanent vision troubles. The risk of retinal damage is higher in people with pre-existing eye problems, kidney disease, or people that also take tamoxifen. Call your physician as soon as possible if you have been revealed to malaria, or if you have fever or other symptoms of ailment during or after a remain in an area where malaria is common. 400 mg salt by mouth once a week Weight-based dosing: 6. 5 mg/kg salt orally once a week -Maximum dose: 400 mg salt/ dosage Comments: -This medication needs to be administered on the same day of each week. Use: For the treatment of malaria in geographical areas where chloroquine resistance is not reported U.S. CDC Recommendations: 310 mg base orally once a week Comments: -An option to chloroquine for treatment only in areas with chloroquine-sensitive malaria -Prophylaxis must start 1 to 2 weeks prior to travel to malarious areas; must proceed weekly while in malarious areas and for 4 weeks after leaving such areas -If malaria develops while utilizing this medication for chemoprophylaxis, it must not be used as part of the therapy program. Uses: For the treatment of chronic discoid lupus erythematosus and systemic lupus erythematosus. Use: For the treatment of chronic and severe rheumatoid arthritis 6. 5 mg/kg salt orally once a week Maximum dosage: 400 mg salt/ dosage Comments: -This medicine needs to be administered on the same day of each week. Use: For the treatment of malaria in geographic areas where chloroquine resistance is not reported U.S. CDC Recommendations: 5 mg/kg base by mouth once a week Maximum dose: 310 mg base/ dosage Comments: -An option to chloroquine for treatment only in areas with chloroquine-sensitive malaria -Prophylaxis must start 1 to 2 weeks before travel to malarious areas; must proceed once a week while in malarious areas and for 4 weeks after leaving such areas -If malaria develops while utilizing this medicine for chemoprophylaxis, it needs to not be used as part of the treatment program. Dosage: 13 mg/kg salt by mouth Second dose: 6. 5 mg/kg salt by mouth Third dose: 6. 5 mg/kg salt by mouth Fourth dosage: 6. 5 mg/kg salt by mouth Maximum Dose: -First dose: 800 mg salt/ dose -Second, 3rd, and 4th dosage: 400 mg salt/ dosage Comments: -Concomitant therapy with an 8-aminoquinoline compound is required for radical remedy of P vivax and P ovale infections. -Recommended for uncomplicated malaria in regions with chloroquine sensitivity -Recommended for uncomplicated malaria in all regions; if treating P vivax or P ovale infections, concomitant treatment with primaquine is advised.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
3652C18H26ClN3O335.9CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCOCCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCOInChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)XXSMGPRMXLTPCZ-UHFFFAOYSA-N2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol3.6335.1764402335.176440248.433102492301010001
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