Primary myelofibrosis is a condition identified by the build-up of mark tissue in the bone marrow, the tissue that produces blood cells. Initially, most people with primary myelofibrosis have no signs or symptoms. Eventually, fibrosis can lead to a reduction in the number of red cell, leukocyte, and platelets. Since blood cell formation in the bone marrow is disrupted, other organs such as the spleen or liver may start to create blood cells. People with splenomegaly might feel pain or fullness in the abdomen, specifically below the ribs on the left side. Primary myelofibrosis is most frequently identified in people aged 50 to 80 but can occur at any age.
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