Summarized by Plex Health
Last Updated: 08 May 2022
a pathway linking oxidative stress and the ran gtpase system in progeria. "a pathway linking oxidative stress and the ran gtpase system in progeria.", by Datta S, Snow CJ, Paschal BM. F3: Fibroblasts from HGPS patients have elevated ROS. (A) ROS detected in primary fibroblasts from control (8469) and progeria patients (1972, 1498, and 3199) using DCF. (B) Histograms comparing total ROS levels in control (black...

Progeria is additionally referred to as Hutchinson-Gilford progeria disorder or the "Benjamin Button" disease. A mutation in the LMNA genetics causes progeria. Most children with progeria don't live past age 13. This leads youngsters with progeria to age swiftly. As children with progeria grow older, they get diseases you would expect to see in people age 50 and older, including bone loss, solidifying of the arteries, and heart problem. Children with progeria usually die of cardiovascular disease or strokes. Progeria does not affect a child's knowledge or brain development. A child with the condition isn't any more likely to get infections than other kids, either. Progeria is uncommon problem. It is remarkable due to the fact that its symptoms strongly resemble normal human aging, yet it occurs in young kids. It is not passed down via families. It is hardly ever seen in more than one child in a family. Development failure throughout the first year of life; Narrow, contracted or wrinkled face; Baldness; Loss of brows and eyelashes; Short stature; Large head for dimension of face; Open soft area; Small jaw; Dry, scaly, slim skin; Limited series of activity; Teeth, delayed or lacking formation; The timeless type of progeria is called Hutchinson-Gilford progeria syndrome, called for the medical professionals who first defined it. Affected individuals commonly die from heart disease throughout late childhood. Therefore the study of progeria is radiating a light on the aging procedure in a manner that might more than the long-term pretty profound.

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