Prurigo Nodularis

"parthenium dermatitis manifesting clinically as polymorphic light eruption and prurigo nodularis- like lesions with vasculitis-like picture on histopathology.", by Lakshmi C, Srinivas CR, Pillai SB, Shanthakumari S. F6: Vertically oriented collagen bundles in the dermis and lymphocytes seen within vessel wall consistent with prurigo nodularis and lymphocytic vasculitis (H and E, ×10)...

Prurigo nodularis is a skin disease that causes hard, scratchy swellings to base on the skin. The itching can be extreme, creating people to damage themselves to the point of bleeding or pain. Scraping can cause more skin lesions to appear. Sometimes, people with PN have a background of other diseases including dermatitis, lymphoma, HIV infection, extreme anemia, or kidney disease. The main symptom of prurigo nodularis is the formation of difficult, very scratchy lumps on the skin. Marking might occur after nodules start to recover. The symptoms of PN can begin at any age however are most common in adults in between 20-60 years. People who have PN might become very concerned about the look of the nodules, and the intensely itchy skin may conflict with rest or with day-to-day tasks. This can cause people with PN to develop stress and anxiety. It is thought that nodules are more probable to develop when skin has been scratched or aggravated somehow. The act of a person damaging skin can cause the nodules to develop. Many individuals with PN have a background of dermatitis, other skin problem, or allergies. When people with PN have a skin biopsy, it can be seen that the nerves in the skin are thickened. It is thought that these thick nerves might send out more powerful signals to the brain that the skin is itchy. Nevertheless, specifically why the skin becomes scratchy in the first place is uncertain and may vary from individual to person.

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