Pulmonary Hypertension

"glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats.", by Yang PS, Kim DH, Lee YJ, Lee SE, Kang WJ, Chang HJ, Shin JS. Fig3: Expression pattern of HMGB1 in the pulmonary vascular lesion. Immunohistochemical staining with anti-HMGB1 antibody (brown color) and counterstaining with hematoxylin was performed on lung tissues of normal control rats and MCT-induced pulmonary hypertension rats...

Pulmonary hypertension happens when the pressure in the capillary leading from the heart to the lungs is too high. With pulmonary hypertension, the blood vessels to the lungs develop an increased amount of muscle mass in the wall of the blood vessels. Due to the fact that the blood does not have to take a trip very far, the pressure in this side of the heart and in the artery taking blood from the right ventricle to the lungs is normally low, usually much lower than systolic or diastolic blood pressure. The symptoms of pulmonary hypertension throughout the preliminary stage of the disease are common to many other medical problems. If you have it, the blood vessels that lug blood from your heart to your lungs come to be tough and narrow. Your heart needs to work more challenging to pump the blood via. Over time, your heart weakens and can refrain from doing its job and you can develop cardiac arrest. As PH worsens, you might locate it hard to do any exercises. They entail treating the heart or lung disease, medications, oxygen, and occasionally lung transplantation. Pulmonary hypertension is a rare problem that can influence people of all ages, but it's more common in people who have another heart or lung condition. If you have a type of pulmonary hypertension called pulmonary arterial hypertension, you might not have any symptoms up until the condition is rather advanced. Since its symptoms are comparable to those of many other heart and lung conditions, appropriately detecting pulmonary hypertension can occasionally take time.

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