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Rifabutin

Summarized by Plex Health
Last Updated: 02 May 2022
rifabutin-associated hypopyon uveitis and retinal vasculitis with a history of acute myeloid leukemia. "rifabutin-associated hypopyon uveitis and retinal vasculitis with a history of acute myeloid leukemia.", by Smith WM, Reddy MG, Hutcheson KA, Bishop RJ, Sen HN. Fig2: Fluorescein angiography montages of the right and left eyes: a, b Baseline (prior to discontinuation of rifabutin). c, d Five weeks after stopping rifabutin. e, f Four months after stopping rifabutin...

Rifabutin is used to avoid mycobacterium avium complex in people with HIV infection. Rifabutin is also used with other medicines to deal with consumption in people with HIV. Rifabutin might additionally be used for purposes not provided in this medicine overview. Rifabutin can make birth control tablets less reliable. Ask your doctor about utilizing non hormone birth control to avoid maternity. If it distress your stomach, rifabutin may be taken with food. The chemical name for rifabutin is 1',4-didehydro-1deoxy-1,4-dihydro-5'-1 oxorifamycin XIV or -6,16,18,20-tetrahydroxy-1'-isobutyl-14-methoxy-7,915,17,19,21,25-heptamethyl-spiro [9,4-2H-furo [2',3':7,8] naphth [1,2-d] imidazole-2,4'-piperidine] -5,10,26-trione-16-acetate. Rifabutin has a molecular formula of C46H62N4O11, a molecular weight of 847. 02 and the complying with structure: Rifabutin is a red-violet powder soluble in chloroform and methanol, moderately soluble in ethanol, and very slightly soluble in water. Its log P value is 3. 2. MAC is an infection brought on by two comparable germs, Mycobacterium avium and Mycobacterium intracellulare. MAC also may occur in other patients whose body immune system is not working appropriately. Symptoms of MAC in people with obtained immunodeficiency syndrome include fever, evening sweats, cools, weight-loss, and weakness. Rifabutin is an antibiotic and works to stop the development or kill of certain microorganisms. It will not help against infections. This medication is available only with your physician's prescription.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
135398743C46H62N4O11847.0CC1C=CC=C(C(=O)N=C2C(=C3C(=C4C2=NC5(N4)CCN(CC5)CC(C)C)C6=C(C(=C3O)C)OC(C6=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)O)CC[[email protected]]1/C=C/C=C(\C(=O)N=C2C(=C3C(=C4C2=NC5(N4)CCN(CC5)CC(C)C)C6=C(C(=C3O)C)O[[email protected]@](C6=O)(O/C=C/[[email protected]@H]([[email protected]]([[email protected]]([[email protected]@H]([[email protected]@H]([[email protected]@H]([[email protected]]1O)C)O)C)OC(=O)C)C)OC)C)O)/CInChI=1S/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,48,52-55H,16-19,21H2,1-11H3/b13-12+,20-15+,24-14-,47-36?/t23-,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1ZWBTYMGEBZUQTK-PVLSIAFMSA-N[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,32-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23-dioxospiro[8,33-dioxa-24,27,29-triazapentacyclo[23.6.1.14,7.05,31.026,30]tritriaconta-1(32),2,4,9,19,21,24,26,30-nonaene-28,4'-piperidine]-13-yl] acetate4.7846.44150881846.441508812092110051456109903301
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