Rifapentine

Summarized by Plex Health
Last Updated: 02 May 2022
development and in vitro characterization of drug delivery system of rifapentine for osteoarticular tuberculosis. "development and in vitro characterization of drug delivery system of rifapentine for osteoarticular tuberculosis.", by Wu J, Zuo Y, Hu Y, Wang J, Li J, Qiao B, Jiang D. f1-dddt-9-1359: SEM images of unloaded PLGA microspheres and RPMs.Notes: (A) RPMs0, (B) RPMs20, (C) RPMs50, (D) RPMs100. RPMs0 denotes unloaded PLGA microspheres, RPMs20, RPMs50, and RPMs100 denote rifapentine-loaded PLGA microspheres with 20, 50, and 100...

PRIFTIN is a rifamycin antimycobacterial medicine showed in patients 12 years old and older for the therapy of active lung tuberculosis brought on by Mycobacterium tuberculosis in combination with several anti-tuberculosis drugs to which the isolate is susceptible. The 150 mg tablets consist of, as non-active active ingredients: calcium stearate, disodium EDTA, FD&C Blue No. 2 aluminum lake, hydroxypropyl cellulose, hypromellose USP, microcrystalline cellulose, polyethylene glycol, pregelatinized starch, propylene glycol, salt ascorbate, salt lauryl sulfate, sodium starch glycolate, artificial red iron oxide, and titanium dioxide. Rifapentine is a rifamycin acquired antimicrobial and has a similar account of microbiological activity to rifampicin. The molecular weight is 877. 04. The molecular formula is C47H64N4O12. The chemical name for rifapentine is rifamycin, 3- [imino] methyl] - or 3- [N-formimidoyl] rifamycin or 5,6917,19,21-hexahydroxy-23-methoxy-2,412,16,18,20,22- heptamethyl-8 [N-formimidoyl] -2,7- naphtho [2,1-b] furan-1,11- dione 21-acetate. It has the adhering to structure.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
135403821C47H64N4O12877.0CC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C=NN5CCN(CC5)C6CCCC6)CC[[email protected]]1/C=C/C=C(\C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)[[email protected]](O4)(O/C=C/[[email protected]@H]([[email protected]]([[email protected]]([[email protected]@H]([[email protected]@H]([[email protected]@H]([[email protected]]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C=N/N5CCN(CC5)C6CCCC6)/CInChI=1S/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14-,48-23+/t24-,26+,27+,28+,33-,38-,39+,43+,47-/m0/s1WDZCUPBHRAEYDL-GZAUEHORSA-N[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-[(E)-(4-cyclopentylpiperazin-1-yl)iminomethyl]-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate6.7876.45207349876.452073492201730061566309904401
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