Riluzole
Summarized by Plex Health
Last Updated: 02 May 2022
"riluzole-triggered gsh synthesis via activation of glutamate transporters to antagonize methylmercury-induced oxidative stress in rat cerebral cortex.", by Deng Y, Xu ZF, Liu W, Xu B, Yang HB, Wei YG. fig4: The figure showed the immunohistochemistry assay of 8-OHdG in cerebral cortex after MeHg exposure and riluzole pretreatment. Light microphotographs were for control (a), riluzole alone (b), MeHg alone (c), and riluzole + MeHg (d)...
Riluzole is used to deal with amyotrophic lateral sclerosis, called ALS or Lou Gehrig's disease. Riluzole is not a remedy for ALS, yet it might prolong survival for patients in the very early stages of the disease or prolong the time up until a tracheostomy is needed. This medication is available only with your physician's prescription.
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Sources:
https://www.drugs.com/mtm/riluzole.html
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd432c13-389e-46b3-8891-0cf1a5880...
https://www.mayoclinic.org/drugs-supplements/riluzole-oral-route/description/drg-20065853
Research Papers' Summaries
PubChem - CovalentUnitCount
(Table source)| CID | MolecularFormula | MolecularWeight | CanonicalSMILES | IsomericSMILES | InChI | InChIKey | IUPACName | XLogP | ExactMass | MonoisotopicMass | TPSA | Complexity | Charge | HBondDonorCount | HBondAcceptorCount | RotatableBondCount | HeavyAtomCount | IsotopeAtomCount | AtomStereoCount | DefinedAtomStereoCount | UndefinedAtomStereoCount | BondStereoCount | DefinedBondStereoCount | UndefinedBondStereoCount | CovalentUnitCount |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5070 | C8H5F3N2OS | 234.20 | C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N | C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N | InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13) | FTALBRSUTCGOEG-UHFFFAOYSA-N | 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine | 3.6 | 234.00746845 | 234.00746845 | 76.4 | 238 | 0 | 1 | 7 | 1 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
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