Ritonavir
Summarized by Plex Health
Last Updated: 02 May 2022
"the bile acid sensor fxr protects against dyslipidemia and aortic plaques development induced by the hiv protease inhibitor ritonavir in mice.", by Mencarelli A, Cipriani S, Renga B, Francisci D, Palladino G, Distrutti E, Baldelli F, Fiorucci S. pone-0013238-g008: Diagramatic representation of the effect exerted by FXR and PPARĪ± ligands on dyslipidemia and accelerated atherosclerosis caused by the HIV-PI ritonavir.Exposure to ritonavir causes SREBP1c activation in the liver and monocytes. In circulating monocytes...
Ritonavir is an antiviral medication that avoids human immunodeficiency virus from increasing in your body. HIV is the virus that causes acquired immune deficiency syndrome. Ritonavir will not protect against or heal HIV infection or AIDS. It helps keep HIV from reproducing and appears to reduce the damage of the immune system. This may help postpone problems that are usually connected to AIDS or HIV disease from taking place. Ritonavir will not keep you from spreading out HIV to other people. People that receive this medication may proceed to have other troubles associated to AIDS or HIV disease. This medication is readily available only with your medical professional's prescription.
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Sources:
https://www.drugs.com/mtm/ritonavir.html
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a32cb2e3-d4e5-4bbf-9d88-20b2b249e...
https://www.mayoclinic.org/drugs-supplements/ritonavir-oral-route/description/drg-20067063
Research Papers' Summaries
PubChem - CovalentUnitCount
(Table source)| CID | MolecularFormula | MolecularWeight | CanonicalSMILES | IsomericSMILES | InChI | InChIKey | IUPACName | XLogP | ExactMass | MonoisotopicMass | TPSA | Complexity | Charge | HBondDonorCount | HBondAcceptorCount | RotatableBondCount | HeavyAtomCount | IsotopeAtomCount | AtomStereoCount | DefinedAtomStereoCount | UndefinedAtomStereoCount | BondStereoCount | DefinedBondStereoCount | UndefinedBondStereoCount | CovalentUnitCount |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 392622 | C37H48N6O5S2 | 720.9 | CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O | CC(C)C1=NC(=CS1)CN(C)C(=O)N[[email protected]@H](C(C)C)C(=O)N[[email protected]@H](CC2=CC=CC=C2)C[[email protected]@H]([[email protected]](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O | InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1 | NCDNCNXCDXHOMX-XGKFQTDJSA-N | 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate | 6 | 720.31276100 | 720.31276100 | 202 | 1040 | 0 | 4 | 9 | 18 | 50 | 0 | 4 | 4 | 0 | 0 | 0 | 0 | 1 |
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