Research has examined numerous possible uses of SAMe, and a substantial variety of studies on clinical depression and liver diseases have been finished. Some of the research studies used injected SAMe, which may not have the same impacts as SAMe taken as a dietary supplement. Data on the lasting safety of SAMe and its security for use while pregnant are too limited to attract any verdicts. SAMe may not be secure for people with bipolar affective disorder. There's academic reason to believe that taking SAMe may advertise Pneumocystis infection in people who are immunocompromised, such as those who are HIV-positive.
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