Summarized by Plex Health
Last Updated: 02 May 2022

SADDAN is a rare disorder of bone growth characterized by skeletal, brain, and skin problems. All people with this problem have very short stature with especially short arms and legs. Structural problems of the brain cause seizures, profound developmental delay, and intellectual special needs. Numerous affected people have had episodes in which their breathing quits or slows for brief durations. Acanthosis nigricans, a progressive skin disorder defined by thick, dark, velvety skin, is another characteristic feature of SADDAN that develops in early stage or early childhood years.

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