Selumetinib

Summarized by Plex Health
Last Updated: 02 May 2022
the discovery of selumetinib "the discovery of selumetinib", by . More than 30 years of NCI-led and NCI-supported research culminated in clinical trials of selumetinib for kids with neurofibromatosis type 1 (NF1) and associated tumors called plexiform neurofibromas (PNs). With Food and Drug Administration (FDA)...

Selumetinib is used to treat neurofibromatosis in children a minimum of 2 years old. Selumetinib is for children with plexiform neurofibromas that can not be operatively eliminated. Selumetinib might be used for purposes not noted in this drug overview. Inform each of your doctor about all your medical problems, allergies, and all medications you use. Selumetinib must not be provided to a child more youthful than 2 years old. A girl that has gotten in adolescence might need to have a negative pregnancy test prior to beginning this therapy. Selumetinib can hurt unborn baby if the mother or daddy is using selumetinib. Take selumetinib with a complete glass of water on an empty stomach, at least 1 hour before or 2 hrs after a dish. Tell your medical professional if the child taking selumetinib has problem swallowing the pill whole. Do not take another dosage if you throw up soon after taking selumetinib. Wait till your next set up dose time to take the medicine again. If you have diarrhea, drink lots of liquids. Selumetinib can cause your heart to pump less blood than normal. Your heart function will need to be examined every 3 to 6 months while you are taking this medicine. Selumetinib can cause eye problems that might lead to blindness. Selumetinib dosages are based on body surface area. Your dosage needs may change if you gain or lose weight or if you are still expanding. Take the medication as soon as you can, however miss the missed out on dosage if your following dosage schedules in less than 6 hrs.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
10127622C17H15BrClFN4O3457.7CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCOCN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCOInChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)CYOHGALHFOKKQC-UHFFFAOYSA-N6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide3.6456.00001456.0000188.452303662700000001
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