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Sickle Cell Reagent Set

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Last Updated: 20 November 2020

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BioMedomics Sickle SCAN is a multiplexed, qualitative, point-of-care immunoassay to aid in rapid diagnosis of Sickle Cell disorders. The test is made up of three indicators which detect the presence of hemoglobins, S, and C, allowing users to rapidly distinguish between normal, carrier, and Sickle Cell Disease samples. Sickle SCAN has both combined sensitivity and specificity of > 99 % and provides results in 5 minutes, making it one of the fastest and most accurate Tests in the world. Sickle Cell Disease is an inherited blood disorder which often causes red blood cells to become Sickle-shape through presence of abnormal Hemoglobin S variant. Highly rigid Sickle-shape blood may have difficulty passing through small blood vessels, blocking normal blood flow, damaging tissues, and ultimately leading to many of complications of SCD. Additionally, RBCs containing mostly Hemoglobin S live only about 16 days compared to 120 days for normal red blood cells. To initiate life-saving therapies, early diagnosis of SCD is key. Before Sickle SCAN, SCD diagnosis was only possible using complex lab equipment. In low-resource regions where SCD is responsible for 9 % of all under-five infant mortality, infrastructure challenges make central lab testing impractical. Sickle SCAN helps overcome diagnostic gap. Ideal for providing quick and accurate results at point-of-care, test requires no supporting equipment and can also be used preventatively for genetic counseling to reduce the incidence of Sickle Cell births. BioMedomics Sickle SCAN Tests for Sickle Cell Trait, Sickle Cell anemia and HbSC Disease. Sickle Cell Trait: People with one Sickle Cell gene and one normal gene have a Sickle Cell Trait. SCT patients usually do not exhibit any of the symptoms of Sickle Cell Disease but have the potential to pass Trait onto their children. If both parents have SCT, there is a 25 % chance their child will be an SCD patient. Sickle Cell Disease: Sickle Cell Disease, inherit blood disorder, often causes red blood cells to become Sickle shape through presence of abnormal Hemoglobin S variant. More rigid Sickle-shape blood may have difficulty passing through small blood vessels, blocking normal blood flow, damaging tissues, and ultimately leading to many of the complications of Sickle Cell Disease. HbSC Disease: HbSC Disease patients have Hemoglobin C and Hemoglobin S, which are both abnormal hemoglobins. HbSC Disease is a milder sickling disorder, and symptoms are similar to that of SCDs but are less frequent and less severe. Other tests typically used for diagnosis of Sickle Cell Disease and Trait are: Hemoglobin Electrophoresis, Hemoglobin isoelectric focusing, and Hemoglobin fractionation by HPLC. Hemoglobin S Solubility testing is sometimes used only for diagnosing Sickle Cell Disease, but it cannot be used for newborn screening and has very low predictive value. With the exception of Solubility testing, all of these Tests need to be conducted in a lab setting, and when considering the cost of sample transportation, equipment, and technicians involve, these lab Tests can be more costly and time-consuming than point-of-care Tests.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Introduction

Table

Results SeenConditionGenes
Slightly decreased Hb A; Moderate amount Hb S (about 40%)Sickle cell traitOne gene copy for Hb S ( heterozygous )
Majority Hb S; Increased Hb F (up to 10%); No Hb ASickle cell diseaseTwo gene copies for Hb S ( homozygous )

A Reference range for your tests can be found in your Laboratory report. They are typically found to be right of your results. If you do not have your lab report, consult your healthcare provider or laboratory that perform Test to obtain Reference range. Laboratory test results are not meaningful by themselves. Their meaning comes from comparison to Reference Ranges. Reference ranges are values expected for a healthy person. They are sometimes call normal values. By comparing your Test results with reference values, you and your healthcare provider can see if any of your test results fall outside the range of expected values. Values that are outside expect ranges can provide clues to help identify possible conditions or diseases. While the accuracy of laboratory testing has significantly evolved over the past few decades, some lab-to-lab variability can occur due to differences in testing equipment, chemical reagents, and techniques. This is the reason why so few Reference Ranges are provided on this site. It is important to know that you must use the range supplied by the laboratory that perform your test to evaluate whether your results are within normal limits. For more information, please read the article Reference range and What They Mean. Sickle Cell Anemia is an inherited disorder that leads to production of an abnormal type of Hemoglobin called Hemoglobin S. Sickle Cell tests determine the presence and relative amount of Hemoglobin S in blood sample or detect mutations in genes that produce Hemoglobin to help diagnose Sickle Cell Anemia and / or identify people With Sickle Cell trait. Hemoglobin is a protein in red blood cells that bind to oxygen in the lungs and carries it to tissues throughout the body. Typically, Hemoglobin makes up most of Hemoglobin found in normal RBCs in adults, with small amounts of Hemoglobin A2 and Hemoglobin F. Before babies are born, they normally produce large amounts of Hemoglobin F, which is then replaced by Hb AS, predominant Hemoglobin shortly after birth. Sickle Cell disease is an inherited condition, passed from parents to children. Inheriting mutations in genes that code for production of Hemoglobin can lead to abnormal types of Hemoglobin, such AS Hb S and Hemoglobin C. Hemoglobin Cis one of the more common Hemoglobin variants and may cause no symptoms or mild illness. Sickle Cell disease and anemiaa person who inherits two abnormal gene copies, one of which is Hb S gene, has Sickle Cell disease person who inherits two Hb S gene copies has Sickle Cell Anemia, most common and serious for of Sickle Cell disease. A Sickle Cell trait person who inherits one normal Hemoglobin gene copy from one parent and Hb S gene copy from other parent has a Sickle Cell trait and is a Sickle Cell carrier. Carriers generally don't experience signs and symptoms associated with Sickle Cell disease but can pass mutation to their children.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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