Simvastatin

Summarized by Plex Health
Last Updated: 03 May 2022

Simvastatin is a prodrug of 3-hydoroxy-3methylglutaryl coenzyme A reductase inhibitor that is derived synthetically from a fermentation item of Aspergillus terreus. Simvastatin is butanoic acid, 2,2-dimethyl -,123788 a-hexahydro-3,7-dimethyl-8 [2-ethyl] -1 naphthalenyl ester, [1S- [1,3,7,8,-8a] The molecular formula of simvastatin is C 25H 38O 5 and its molecular weight is 418. 57. Simvastatin tablets, USP for oral use consist of 5 mg, 10 mg, 20 mg, 40 mg or 80 mg of simvastatin, USP and the following inactive components: ascorbic acid, citric acid monohydrate, hydroxypropyl cellulose, hypromellose, iron oxide yellow, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized maize talc, titanium, and starch dioxide. Your physician might suggest simvastatin if you have a family history of cardiovascular disease, or a long-lasting health problem such as rheumatoid arthritis, or type 1 or type 2 diabetic issues. Simvastatin is additionally available as tablets combined with other medications that lower cholesterol: Cholib, incorporated with fenofibrate; Inegy, incorporated with ezetimibe. Lots of people with high cholesterol do not have any symptoms, yet keep taking simvastatin even if you really feel well. Do not take simvastatin if you're pregnant. Simvastatin is also used to lower the risk of stroke, heart attack, and other heart problems in people with diabetes mellitus, coronary heart problem, or other risk variables. Your physician might need to change your treatment plan if you use specific anti-biotics or antifungal medications, hepatitis C drug, heart medication, or medications to deal with HIV/AIDS. Use effective contraception to stay clear of maternity while you are taking this medication. Your physician might occasionally change your dose to see to it you get the most effective results.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
54454C25H38O5418.6CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)CCCC(C)(C)C(=O)O[[email protected]]1C[[email protected]](C=C2[[email protected]]1[[email protected]]([[email protected]](C=C2)C)CC[[email protected]@H]3C[[email protected]](CC(=O)O3)O)CInChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1RYMZZMVNJRMUDD-HGQWONQESA-N[(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate4.7418.27192431418.2719243172.870601573007700001
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