Sitagliptin

Summarized by Plex Health
Last Updated: 02 May 2022
dpp-4 inhibitor sitagliptin prevents inflammation and oxidative stress of heart and kidney in two kidney and one clip (2k1c) rats. "dpp-4 inhibitor sitagliptin prevents inflammation and oxidative stress of heart and kidney in two kidney and one clip (2k1c) rats.", by Alam MA, Chowdhury MR, Jain P, Sagor MA, Reza HM. Fig4: Effect of sitagliptin on kidney fibrosis in 2K1C model rats. a Sham; b Sham + Sitagliptin; c 2K1C and d 2K1C + Sitagliptin. No pathological collagen tissue deposition was observed in Sham animals (a)...

Sitagliptin is used along with diet regimen and exercise to boost blood glucose control in adults with type 2 diabetes mellitus. Sitagliptin might be used for functions not detailed in this medication overview. Stop taking sitagliptin and call your doctor if you have symptoms of pancreatitis: serious pain in your upper stomach spreading out to your back, with or without vomiting. Managing diabetic issues is very essential while pregnant, and having high blood sugar might cause complications in both the baby and the mother. Your blood sugar level will require to be examined usually, and you may require other blood tests at your physician's office. Your medical professional may prescribe a glucagon injection package in instance you have serious hypoglycemia. Type 2 diabetes is a condition where the body does not make adequate insulin, or the insulin that it manages not work effectively. Sitagliptin is recommended for people who still have high blood sugar, even though they have a sensible diet and workout regularly. It additionally comes as tablets having a mixture of sitagliptin and another diabetic issues medicine called metformin. You need to take it on a daily basis to make certain your blood glucose remains as steady as possible. You take sitagliptin once a day. Sitagliptin phosphate monohydrate is described chemically as 7- [3amino-1oxo-4butyl] -5,678-tetrahydro-31,24-triazolo [4,3-a] pyrazine phosphate monohydrate. The structural formula is: Sitagliptin phosphate monohydrate is a white to beige, crystalline, non-hygroscopic powder. Each film-coated tablet computer of JANUVIA includes 32. 13, 64. 25, or 128. 5 mg of sitagliptin phosphate monohydrate, which amounts 25, 50, or 100 mg, specifically, of free base and the adhering to inactive components: microcrystalline cellulose, anhydrous dibasic calcium phosphate, croscarmellose salt, magnesium stearate, and sodium stearyl fumarate. Furthermore, the film covering has the complying with non-active components: polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, red iron oxide, and yellow iron oxide.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
4369359C16H15F6N5O407.31C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)CC(CC3=CC(=C(C=C3F)F)F)NC1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[[email protected]@H](CC3=CC(=C(C=C3F)F)F)NInChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1MFFMDFFZMYYVKS-SECBINFHSA-N(3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one0.7407.11807909407.1180790977566011042801100001
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