Summarized by Plex Health
Last Updated: 02 May 2022
cardiac magnetic resonance assessment of interstitial myocardial fibrosis and cardiomyocyte hypertrophy in hypertensive mice treated with spironolactone. "cardiac magnetic resonance assessment of interstitial myocardial fibrosis and cardiomyocyte hypertrophy in hypertensive mice treated with spironolactone.", by Coelho-Filho OR, Shah RV, Neilan TG, Mitchell R, Moreno H, Kwong R, Jerosch-Herold M. fig04: Short‐axis, mid‐level sections of cardiac tissue from the left ventricle (LV) in mice treated with l‐NAME (A and C), and spironolactone and l‐NAME (B and D), after 7 weeks of l‐NAME. Short‐axis sections stained...

Spironolactone oral tablets contain 25 mg, 50 mg, or 100 mg of the aldosterone antagonist spironolactone, USP 17-hydroxy-7 -mercapto-3oxo-17 -pregn-4ene-21-carboxylic acid -lactone acetate, which has the following structural formula: Spironolactone, USP is openly soluble in benzene and chloroform; soluble in ethyl acetate and in alcohol, somewhat soluble in ether, in methanol and in repaired oils and virtually insoluble in water. Inactive components include calcium sulfate dihydrate, corn starch, ferric oxide black, ferric oxide red, ferric oxide yellow, peppermint, hypromellose, magnesium stearate, polyethylene titanium, povidone, and glycol dioxide. Spironolactone also treats fluid retention in people with heart disease, cirrhosis of the liver, or a kidney disorder called nephrotic disorder. Spironolactone is used to treat a condition or identify in which you have too much aldosterone in your body. If you are pregnant, your physician ought to decide whether you take spironolactone. Your doctor may sometimes change your dose. You may take spironolactone with or without food, yet take it the same way each time. High blood pressure often has no symptoms. You may need to use high blood pressure drug for the rest of your life. Decreasing high blood pressure can reduce the risk of strokes and heart attacks. Spironolactone is also used to minimize the need for a hospital stay for heart failure. Spironolactone is a potassium-sparing diuretic. This medication is additionally used to avoid or deal with hypokalemia. This medicine is readily available only with your medical professional's prescription.

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PubChem - CovalentUnitCount

(Table source)
5833C24H32O4S416.6CC(=O)SC1CC2=CC(=O)CCC2(C3C1C4CCC5(C4(CC3)C)CCC(=O)O5)CCC(=O)S[[email protected]@H]1CC2=CC(=O)CC[[email protected]@]2([[email protected]@H]3[[email protected]@H]1[[email protected]@H]4CC[[email protected]]5([[email protected]]4(CC3)C)CCC(=O)O5)CInChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1LXMSZDCAJNLERA-ZHYRCANASA-NS-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate2.9416.20213067416.2021306785.781800522907700001
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