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Stem Cell Research Foundation

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Last Updated: 23 October 2020

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Site navigation utilizes arrow, enter, escape, and space bar key commands. Left and right arrows move across top level links and expand / close menus in sub levels. Up and Down arrows will open main level menus and toggle through sub tier links. Enter and space open menus and escape close them as well. Tab will move on to the next part of the site rather than go through menu items. As a service to our field, ISSCR identifies Stem Cell - related Funding Opportunities across many domains of biomedical Research. Organizations and opportunities listed below are independent of any ISSCR programs or Funding Alexander von Humboldt Foundation Sponsorship Programmes: Fellowships and Research Awards non - profit Foundation established by the Federal Republic of Germany For Promotion of International Research cooperation. The funding range includes Research Awards and Fellowships for applicants both abroad and from Germany. Research Programmes. Alliance For Regenerative Rehabilitation and Training Center National Network that supports expansion of scientific knowledge, expertise and methodologies across fields of Regenerative Medicine and Rehabilitation through education, Training, Research support, and Funding Opportunities. Funding Opportunities. Alzheimers Research Trust, UK's leading research charity for dementia. Funds Researchers in the UK working on all aspects of translational pathway including basic research, early detection, risk factor identification, alleviation and progress towards effective treatments for Alzheimers and related dementias. International collaborations with UK - base lead researcher consider. Research Programmes. The American Cancer Society Offering range of research grants and career development grants. Research programs and Funding. American Health Assistance Foundation Funds Research on Alzheimer's disease, glaucoma, and macular degeneration. Awards are separate by research area. Biotechnology and Biological Sciences Research Council, UK BBSRC provides funding to scientists working at UK universities and in BBSRC - sponsored Research Institutes. Generally, researchers can apply at any time for Funding for Research that is within the Committee's authority, preferably in priority areas identified by the Committee. Studentships and Fellowships are also available. Research Funding. British Heart Foundation British Heart Foundation is the major funder of basic and clinical cardiovascular research in the UK, with a series of research grant funding schemes at all levels. For details, access research pages on the BHF website. Applications are accepted throughout the year. California Institute of Regenerative Medicine Funds basic and applied biomedical Research focus on developing diagnostics and therapies and on other vital research opportunities that will lead to life - saving medical treatments. Grants are made only to California - based research institutions. View list of current Funding Opportunities. Deutsche Forschungsgemeinshaft offers a wide range of Funding Opportunities to Research scientists in Germany, For Research Training For German Young investigators and For Promotion of Scientific contact between Germany and the research community worldwide Deadlines: Largely on continuous application system, European Molecular Biology Organisation offers awards and financial support for scientists at all stages of their careers that help To create environment where Researchers can achieve their best work.

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Upcoming Funding Opportunities

The California Institute for Regenerative Medicine makes grants and provides loans for Stem Cell Research, research facilities, and other research opportunities at California universities and research institutions. The Connecticut Stem Cell Research Program provides grants - in - aid for conducting embryonic or human adult Stem Cell Research. Maryland Technology Development Corporation provides emerging technology companies and university researchers with funding and specialized technical assistance. Stem Cell Institute of New Jersey UMDNJ - Robert Wood Johnson Medical School and Rutgers, State University of New Jersey have jointly established the Stem Cell Institute of New Jersey. The mission of the Institute is to carry out research, training, and clinical studies on application of stem cells to treatment and cure of human disease. New York Stem Cell Science Supports basic, apply, translational or other Research and Development activities that will advance scientific discoveries in fields related to Stem Cell biology. The National Center for Regenerative Medicine Center builds upon Research and Clinical Programs at its founding institutions - Case Western Reserve University, Cleveland Clinic, University Hospitals Case Medical Center, athersys, and Ohio State University - in heart disease, cancer, genetic Disorders, and neurodegenerative diseases, coupled with Research on non - embryonic Stem cells at these institutions. The center seeks to translate innovative laboratory research into clinical and commercial arenas to replace and repair diseased tissues and organs. The Interstate Alliance on Stem Cell Research fosters effective interstate collaboration, helps states develop Research Programs, and promotes efficient and responsible use of public funds. For more information, Download Stem Cell Research: State Initiatives, 2006 Report from Library of Congress's Congressional Research Service. Links included here connect you to other Internet sites that operate independently of NIH. Nih is not responsible for the availability or content of other sites. Permission to reproduce information at other sites may be require. Nih does not endorse, warrant, or guarantee information, services, or products described or offered at these external sites.

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Support Alternatives

Susan G. Komen for Cure Foundation has been in the news because of its clash with the Parenthood Federation of America. But another aspect of Komen's activities hasn't received much attention: Komen's position on research using Human embryonic Stem Cells. Despite raising millions of dollars for breast Cancer Research, Komen hasn't funded any of this work, prompting questions about whether that decision is rooted in politics. We find this disappointing and really fairly ironic for a group that is for cure to walk away from research that many scientists think could unlock cures for diseases, including cancer, says Sean Tipton of Coalition for Advancement of Medical Research, which lobbies for Research With Human embryonic Stem Cells. Many scientists think human embryonic Stem Cells could lead to cures for many ailments, including heart disease, Diabetes, some forms of blindness and possibly Cancer. But human embryos have been destroyed to obtain some of the cells. So research has long been controversial. Anything that involves reproductive biology, whether it's sex survey among high school students or contraceptive services, abortion, immediately stirs up political passions, says Daniel Greenberg, who studies intersection of science and politics. No one from Komen agreed to be interviewed for this story. But officials maintain that group doesn't have a formal Ban on Research involving Human embryonic Stem Cells. They say they just haven't found anything worth funding yet. But Tipton and others say there are many ways Stem Cells could help fight breast Cancer. Embryonic - Stem - Cell work is a powerful research tool for all kinds of diseases and conditions, and breast cancer would certainly be one of those candidates, Tipton say. For example, Stem Cells could be used to study genetic causes of breast cancer, decipher the basic biology of breast cancer tumors and perhaps test new drugs to treat the disease, Tipton and others say. Now, it turns out, Komen is alone. Neither the American Cancer Society nor the American Heart Association funds research into Human embryonic Stem Cells. That's frustrating for many scientists. Funding science is supposed to be based on merit, says George Q. Daley, Stem - Cell researcher at Harvard University. Scientific funding should support the best ideas. And if someone has brilliant idea relevant to breast Cancer Research or heart disease that uses Human embryonic Stem Cells, it d be a huge lose opportunity to have one of these foundations refuse to fund it. Charitable groups can be skittish about politically sensitive research because of fears of alienating some of the legions of volunteers and donors they depend on for survival, Greenberg say. These groups live on handouts from the public and they are very, very concerned about offending any donors or potential donors. It's very easy to scare them off, Greenberg say. Various groups that have particular issue to push know about this sensitivity and vulnerability of charitable organizations and they re able to manipulate it very well. Rise Marie Robertson, chief science officer at American Heart Association.

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Spinal Cord Injury

The spinal Cord is a collection of millions of nerve cells inside our spine that send signals to and from the brain. Damage to this important and delicate tissue is often permanent and can result in paralysis. There are presently no effective treatments for restoring Spinal Cord function. However, several current clinical studies are testing the safety and effectiveness of Stem Cells as treatments. These Treatments hope to at least partially restore function to the Spinal Cord. Several studies have shown promising results, but definitive outcomes are still unknown. Inflammation and toxins released by damaged cells At site of Spinal Injury often cause further harm to surrounding cells. Researchers are developing treatments that reduce inflammation and soak up toxins and free radicals to minimise additional damage. Spinal Cord Injuries often damage neurons and supporting cells that wrap & insulate neurons. Damaging supporting cells can cause otherwise functional neurons to die. Researchers are studying how Stem Cells might be used to replace neurons and their supporting cells to greatly improve patients ' chances of recovering function. Most Stem Cell Treatments presently in clinical trials rely on transplanted Stem Cells to automatically repair damaged areas of the Spinal Cord. It is not know how reliable and reproducible this treatment will be for different patients and types of injuries. Stem Cell Treatments for Spinal cords are thought to work best if offered in a short time - frame after injury. Scarring At site of injury can hinder effectiveness of treatment, so this also needs to be address. It isnt yet clear how much function can be restored with Stem Cell Treatments presently in clinical trials. The Spinal Cord is a delicate tissue encase in and protected by hard vertebrae of the spinal column. Together, brain and the Spinal Cord form the body's Central Nervous System. The spinal cord is made up of millions of nerve cells that carry signals to and from the brain and into other parts of the body. This information allows the US to sit, run, go to the toilet and breathe. The main cell type found in the Spinal Cord, neuron, conveys information up and down the Spinal Cord in the form of electrical signals. Axon is a long, slender projection of neuron that conducts these signals away from the neuron's cell body. Each neuron has only one axon, and it can be as long as the entire Spinal Cord, up to 45cm in an adult human. Axons that carry messages down the Spinal Cord are called motor axons. They control the muscles of internal organs and those of legs and arms. They also help regulate blood pressure, body temperature, and body response to stress. Axons that travel up cord carry sensory information from skin, joints and muscles and from internal organs. These are sensory axons. Neurons in the Spinal Cord also need support from other cell types.

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Type 1 (Juvenile) Diabetes

It stands to reason that only by understanding the root causes of diseases like Diabetes can we hope to develop effective therapies. Modern biomedical research is best at finding treatments for diseases that have relatively simple causes and well - understood genetic risk factors. Unfortunately, Type 1 Diabetes has very complex genetics, with many genes each making relatively small, poorly understood contributions to disease risk. Further, there are no animal models that accurately reflect human disease. Thus, despite expenditure of hundreds of millions of research dollars, no cures for T1D have been develop. T1d is particularly challenging to study in human patients. By TIME, patient is diagnosed with T1D, also know as Juvenile Diabetes, destruction of insulin - producing beta cells by the Immune system is nearly complete. Because of this, there is no way to discover what it was that led persons Immune system to attack beta cells in the first place. Even if it were possible to identify future T1D patients before Immune attack on beta cells begin, disease onset and progression could not be studied in these individuals due to inaccessibility of Pancreas - where beta cells are found - in living people


Diabetes

In 2017, research gathered and analyzed 13 studies published between 2006 and 2016 comprising 342 patients who received stem cells like those abundant in cord blood and another 111 who received stem cells like those abundant in cord tissue to treat their diabetes. While not everyone responds to treatment, researchers observe improved glucose control and reduced dependence on insulin lasting up to four years. While the results show promise for treatment of Diabetes using stem cells, they still leave a few questions unanswered, including who were ideal candidates, what was the best route of administration, what was the optimal dose and was there a need for multiple transfusions.


Making Beta Cells

The fourth approach is not to turn other cells into beta cells but to get beta cells to make more of themselves. Thanks to work coming out of the Melton lab, it is now understood that beta cells in the pancreas do make more of themselves, albeit very slowly and at a low rate. This replication slows down even further with age. These findings suggest that a possible strategy for type II diabetes and very early - diagnosed T1D is to increase beta cell replication rate. Intrigue by the fact that the number of beta cells increases significantly in pregnant mammals, Melton lab studied differences in genes that are on or off before, during, and after pregnancy. Researchers identified several causal factors that led to the recent formation of a three - way joint development agreement between a lab, biotechnology company, and large pharmaceutical company to develop drugs that could affect this pathway. If successful, this development will result in a drug that can directly raise the number of beta cells by stimulating replication.


Stem Cell Educator Therapy

The newly developed Stem Cell Educator uses novel Cell identified by Dr. Yong Zhao as having embryonic and hematopoietic characteristics. Dr. Zhao says these cord blood - stem cells can be used to re - educate lymphocytes and stop autoimmune responses. Educators circulate patients ' blood through a close - loop system that separates mononuclear cells from whole blood, briefly co - culture them with adherent cord blood - Stem cells and returns re - educate cells to patient circulation. Stem Cell Educators do not introduce new stem cells into patients in comparison with other Stem Cell - base therapies. In addition, in prior trials, Dr. Zhao said educator eliminates the need for prior matching and treatment takes as few as 8 - 10 hours.

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Auto-Immune Disorders

Autoimmune disorders occur when the body fails to tell the difference between self and non - self. When this happen, body makes antibodies that are directed towards the body's own tissues. These are called auto - antibodies. Autoantibodies attack normal, healthy cells by mistake. Autoimmune Diseases can affect various organs and organ systems. Immune system activity causes inflammation of affected tissue, which can lead to damage that affects normal function. In the United States, AT least 23. 5 million people are affected by Autoimmune disorder. These disorders are one of the leading causes of death and disability. Traditional treatment methods focus on reducing normal immune system activity, often impacting other aspects of overall health and mobility. Use of steroid - base medications and therapies is common for many Autoimmune Diseases, but these necessary treatments can have side effects that damage healthy tissue and affect physical health in the long run. Dr. Todd Malan offers Stem Cell therapy for patients with a range of Autoimmune disorders that has been effective in restoring health and function of damaged tissue For both improving overall health and disease management. At Center For Regenerative Cell Medicine in Scottsdale, AZ we are currently studying and offering treatment for the following disorders:


What is Autoimmune Diseases?

The accompanying article illustrates statistics on clinical trials from the past five years. Many of these clinical trials rely on stem cells to modulate patients ' immune system, but not to completely replace them A Worldwide review article published by Chen & Ding in Feb. 2016 identified 16 trials using MSC Cell therapy for MS patients, conducted in 11 countries and using a variety of graft sources: MSC from bone marrow, from umbilical cord tissue, and from adipose tissue. Our accompanying article finds that among 58 clinical trials for any autoimmune disease that were registered over the past five years, 62% of patients are receiving MSC therapy. One new approach to treating MS patients using MSC is a phase 1 clinical trial at Tisch MS Research Center in New York. Trial, led by Center director Dr. Saud Sadiq, uses autologous MSC from patients ' bone marrow which they manipulate in the laboratory to derive neural progenitor stem cells. In this Tisch trial, patients do not receive chemotherapy, and cord Blood Stem cells are administered via three intrathecal injections of 2 - 10 million cells per dose at 3 month intervals. Although this Tisch trial was only intended to assess the safety of the intrathecal method of Stem Cell delivery, they report that 70% of 10 MS patients treated so far had improvement in their level of disability. The transition to treating autoimmune diseases with MSC instead of HSC leads to many new options for patients. On one hand, today children could use MSC from their own cord tissue or placenta for personalized Stem Cell therapy of any autoimmune disease they may develop later in life. On the other hand, banks of donated perinatal stem cells could become sources for off - shelf stem cell therapies in which patients do not have to provide their own stem cells. The accompanying story of Hepsi Zsoldos tells how donated cord blood helped one patient with autoimmune disease. The future of Stem Cell therapy for autoimmune diseases such as MS shows great hope. If anything, patients now face a bewildering variety of clinical trial choices, in terms of what stem cells trials are using, how patients are prepared, and how cells are deliver. Hopefully, next decade of research will bring some clarity to competing efforts to stop and ultimately cure MS.

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Overview

Recent advances in biomedical research have raised hope of curing diseases such as Parkinsons Disease, diabetes, Alzheimers, AIDS, spinal cord injury, heart failure and cancer. These diseases are the result of death of specific types of cells, such as nerve cells and cells in the pancreas that produce insulin. For reasons not entirely understood, dead cells are not automatically replaced by new cells. This is in contrast to other tissues, such as skin and blood, that routinely replace dying cells with new cells. New Cells that can replace dead cells are recruited from reserve supply of cells that have maintained potential to divide and multiply when called upon. They also also have maintain potential to mature into specific type of cell that is needed. Such cells with lasting ability to divide and mature into new functional cells when needed are termed Stem Cells. Scientists have discovered that stem cells can grow to high numbers in laboratory culture dishes, and then be encouraged to differentiate into specific cell types, such as heart muscle cells and nerves. Experiments with laboratory mice have demonstrated that stem cells grown in laboratories can replace dead cells in organs such as the heart, which apparently do not have its own supply of stem cells. These encouraging results have spawned numerous studies to learn to apply Stem cell therapy to humans. The principal problem facing biomedical scientists studying stem cells is the source of stem cells for tissues and organs that do not have their own supply. Alternate sources of Stem Cells are fetal tissues and abandon, frozen embryos in infertility clinics. These sources are morally unacceptable to many US citizens and research has been stalled by moral outrage and lack of government funding. Until more advances are made in understanding how to reprogram adult cells to become Stem Cells, best way to accomplish this is to use human eggs. Some methods of generating human Stem Cells from human eggs do not require that eggs be fertilized by sperm. Although still controversial, use of unfertilized human eggs to generate Stem Cells is more acceptable to many US citizens. To advance treatment opportunities, foundation is raising funds to help bridge the gap created by lack of government funding. The Foundation hops to fund and carry on innovative projects to discover how to produce Stem Cells from unfertilized human eggs.


What are stem cells?

Unfertilized human eggs activated in laboratory, term parthenotes, can divide into stem cells with capacity to develop into any body tissue type. In 2001, BRF trustee, Dr. Jose Cibelli, used monkey eggs to report the first derivation of primate parthenote stem cells. Scientists throughout the world are now using monkey parthenote stem cells for various studies, including one that alleviates Parkinsons disease in monkey model. Dr. Cibelli and BRF Director, Dr. Ann Kiessling, extended this work to human eggs in 2002. Their pioneering research shows that, like monkey eggs, human eggs could be activated in the lab to divide into many cells, giving hope that line of human parthenote stem cells could be develop.

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Text of measure

There is hereby established California Institute for Regenerative Medicine. To make grants and loans for Stem Cell research, for research facilities, and for other vital research opportunities to realize therapies, protocols, and / or medical procedures that will result in, as speedily as possible, cure for, and / or substantial mitigation of, major diseases, injuries, and orphan diseases. To support all stages of the process of developing cures, from laboratory research through successful clinical trials. To establish appropriate regulatory standards and oversight bodies for research and facilities development. Section 3. No funds authorized for, or made available to, Institute shall be used for research involving human reproductive cloning. Section 4. Funds authorized for, or made available to, Institute shall be continuously appropriate without regard to the fiscal year, be available and used only for purposes provided in this Article, and shall not be subject to appropriation or transfer by the Legislature or Governor for any other purpose. Section 5. There is hereby established right to conduct Stem Cell research which includes research involving adult Stem cells, cord blood Stem cells, pluripotent Stem cells, and / or progenitor cells. Pluripotent Stem cells are cells that are capable of self - renewal, and have broad potential to differentiate into multiple adult cell types. Pluripotent Stem cells may be derived from somatic cell nuclear transfer or from surplus products of in vitro fertilization treatments when such products are donated under appropriate informed consent procedures. Progenitor cells are multipotent or precursor cells that are partially differentiate, but retain the ability to divide and give rise to differentiated cells. Section 6. Notwithstanding any other provision of this Constitution or any law, institute, which is established by the state government, may utilize state issued tax - exempt and taxable bonds to fund its operations, medical and scientific research, including therapy development through clinical trials, and facilities. Section 7. Notwithstanding any other provision of this Constitution, including Article VII, or any law, Institute and its employees are exempt from civil service.

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Opposition

In 2001, President George W. Bush issued rule limiting federal Funding For Research involving Human Embryonic Stem cells, including funds from the National Institutes of Health, world's largest single source of funds for Stem Cell Research. 1 For institutions that use nonfederal Funding sources to continue Stem Cell Research, rules require use of alternative laboratory space and equipment that has not been purchased or built with federal funds. 2 in reaction to federal policy, Citizens of California take Stem Cell Research into their own hands: in 2004, voters passed the California Research and Cures Initiative, which amended the state constitution to make Stem Cell Research a constitutional right and created an institution—the California Institute For Regenerative Medicine —to fund, facilitate, and provide Oversight For Stem Cell Research in State. 3 Initiative provides a mechanism to fund Stem Cell Research with $3 billion over a decade through sale of public bonds, with interest payable from the State's general fund, amounting to an additional $3 billion. The initiative was specifically designed to protect Stem Cell Research in California from many typical impediments, including unpredictability of funding, legislative interference, and regulatory restrictions. The cirm is a semiautonomous institution; although it operates as an agency of the State executive branch, its governing Board, Independent Citizens Oversight Committee, is responsible for CIRM's governance and administration. Icoc also administers CIRM's financing, together with California Stem Cell Research and cure Finance Committee, State agency created by the Initiative to handle bond issues. Icoc also coordinates 3 policy - setting working groups mandated by the Initiative: Scientific and Medical Research Funding, Scientific and Medical Research Facilities, and Scientific and Medical Accountability Standards. We undertake subjective review of CIRM's history, including its political and legal aspects and present status. We conducted semistructured interviews and discussions with 17 key stakeholders: principal supporters and opponents of the Initiative campaign; past and present CIRM officers and staff; ICOC members; State legislators; critics of CIRM; and representatives of watchdog organizations. Interviews were tailored to elicit information or opinions on aspects of subject most germane to each interviewee's knowledge of and role in CIRM activities. We follow initial stages of interviews with discussion and further questions to pursue in greater depth significant themes that arose during interviews. Four respondents interviewed early in the project were subsequently reinterviewed. All respondents gave informed consent and were guaranteed confidentiality. No requested interviews were refuse. We also analyze government documents, litigation briefs and opinions, transcripts of CIRM meetings and other materials from CIRM Web site, media accounts, and policy papers and materials from other sources, including advocacy organizations and watchdog groups. We do not attempt formal tabulation of interview responses beyond listing several relevant themes, to ensure that they are covered in future interviews or reinterviews.

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Background

Innovation Award: With motto, We will not rest until we find Cure, Cystic Fibrosis Foundation is geared towards successful development and delivery of treatments, therapies and cure for every person with Cystic Fibrosis. Cf Foundation has added decades to the lives of people with disease as a direct result of advances in treatment and care made possible through its innovative business model - venture philanthropy. The Foundation recently unveiled its Path to Cure Research agenda aimed at addressing root genetic causes of disease and is currently funding industry programs aiming at gene delivery with the goal of progressing into clinical studies in 2021. Inspiration Award: Emily Whitehead Foundation is a nonprofit organization committed to raising funds to invest in the most promising pediatric Cancer Research. Tom and Kari Whitehead found EWF in honor of their daughter Emily, first child in the world to receive CAR T - Cell therapy, training her own cells to fight Cancer. Her inspiring story focuses public attention on the potential for cancer immunotherapy to transform Cancer treatment, as well as the need to support lifesaving Cancer immunotherapy research. The foundation provides support to pediatric cancer patients and promotes awareness of the disease through education and sharing other inspiring stories. Advocacy Award: Gift of Life Marrow Registry was established in 1991 by Jay Feinberg and his family after Jay received life - saving bone marrow transplant. Gift of Life is dedicated to saving lives and facilitating bone marrow and Blood Stem Cell transplants for patients with leukemia, lymphoma, sickle Cell and other diseases. In 2019, Gift of Life open world first apheresis Center fully integrated within Registry, Dr. Miriam and Sheldon G. Adelson Gift of Life - Be Match Stem Cell Collection Center. With Collection Center and rapidly expanding donor database, Gift of Life will launch a biobank to advance cellular therapies using allogeneically source cells in 2020. Leadership Award: Ret. Major General Bernard Burn Loeffke, PhD. Is highly decorated Special Forces officer, diplomat and medical officer. He survived two helicopter crashes and was wound in combat. After the Vietnam War, he served as Army Attache at the US Embassy in Moscow, first Defense Attache at the US Embassy in Beijing, staff officer in White House, and Director of the Commission on White House Fellows. His last command was Commanding General of Army South. After 35 years in the Military, he became a medical officer traveling around the world on relief missions to third and Fourth World countries. Presently, at age 85, he champions hydrocephalus and wound warrior communities. He continues to serve as an inspiration and supporter of building peaceful international relations through medical partnerships and played a pivotal role as keynote speaker at the inaugural 2019 World Stem Cell Summit CHINA. He is called the Peace General in Latin America. In CHINA, he is simply known as General, our friend.

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Sources

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