Stiff-Person Syndrome

"lockjaw in stiff-person syndrome with autoantibodies against glycine receptors.", by Doppler K, Schleyer B, Geis C, Grünewald B, Putz E, Villmann C, Sommer C. F2: GlyR antibody bindingAntibodies bind to extracellular domain of glycine receptor subunits. HEK293 cells were cotransfected with GFP and with different glycine receptor subunits 1, 2, 3. Cells were incubated with purified patient IgG (I–L)...

Stiff-person syndrome is uncommon obtained neurological disorder characterized by progressive muscular tissue stiffness and duplicated episodes of agonizing muscle spasms. Muscle rigidity typically varies and usually takes place along with the muscular tissue convulsions. Convulsions may occur arbitrarily or be set off by a variety of various occasions consisting of unexpected noise or light physical contact. Although the precise cause of SPS is unknown, it is thought to be an autoimmune disorder and sometimes occurs together with other autoimmune disorders. Stiff-person syndrome is considered by many researchers to be a spectrum of disease ranging from the involvement of just one area of the body to an extensive, swiftly progressive form that consists of participation of the brain stem and spinal cord.

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