Sulfasalazine

Summarized by Plex Health
Last Updated: 02 May 2022
effect of thiol-reducing agents and antioxidants on sulfasalazine-induced hepatic injury in normotermic recirculating isolated perfused rat liver. "effect of thiol-reducing agents and antioxidants on sulfasalazine-induced hepatic injury in normotermic recirculating isolated perfused rat liver.", by Heidari R, Esmailie N, Azarpira N, Najibi A, Niknahad H. f3-tr-32-133: Histopathological changes of perfused rat liver treated with sulfasalazine (H&E staining). (A) control group perfused with Krebs-Henseleit buffer for 180 mins. No significant pathological changes except for a mild sinusoidal dilation was detected in...

Since it is known to decrease the pain and swelling in arthritis, Sulfasalazine is prescribed to people with rheumatoid arthritis. Since it is a sulfa medication, people with a sulfa allergy ought to not use sulfasalazine. Along with rheumatoid arthritis, sulfasalazine is also recommended for the treatment of other autoimmune problems and inflammatory bowel disorder. Your doctor will prescribe the medicine to you at a low dosage to prevent side effects. Sometimes, people with rheumatoid arthritis might have to take up to 6 pills in a day. One of the most common side effects of sulfasalazine are acid indigestion and feeling sick. Drink lots of fluids when taking sulfasalazine to assist prevent possible kidney issues. To make certain it's risk-free for you, tell your physician before starting the medicine if you: have ever before had an allergy to sulfasalazine, pain killers, or any other salicylates such as methyl salicylate or choline salicylate; have ever before had an allergy to any other medicine; have uncommon blood problem called porphyria; have any problems with your kidneys or liver; are pregnant, trying to get pregnant or breastfeeding. Taking sulfasalazine can make it harder for your body to absorb folic acid, and folic acid assists protect against major abnormality of the infant's brain or spine. You might require to take folic acid supplements if you take sulfasalazine throughout maternity. Sulfasalazine may not boost your symptoms right away, and you might still require your other medications for some time.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
5339C18H14N4O5S398.4C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)OC1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)OInChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)NCEXYHBECQHGNR-UHFFFAOYSA-N2-hydroxy-5-[[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl]benzoic acid-0.7398.06849073398.0684907315065703962800000001
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