Sunitinib

Summarized by Plex Health
Last Updated: 02 May 2022
sunitinib impedes brain tumor progression and reduces tumor-induced neurodegeneration in the microenvironment. "sunitinib impedes brain tumor progression and reduces tumor-induced neurodegeneration in the microenvironment.", by Hatipoglu G, Hock SW, Weiss R, Fan Z, Sehm T, Ghoochani A, Buchfelder M, Savaskan NE, Eyüpoglu IY. fig01: Sunitinib impacts tumor vessels, normalizes vascular morphology, and induces endothelial cell death. (a) Sunitinib does not affect vascular morphology in normal brain tissue. Brain slices in culture were treated with the solvent only as...

Sunitinib is used to deal with a stomach stromal tumor after other medicines did not work effectively. Sunitinib is also used to deal with advanced kidney cancer and as added treatment in patients at high risk for kidney cancer after medical removal of the kidney. Sunitinib is also used to deal with a type of pancreatic cancer called pancreatic neuroendocrine tumor, that can not be surgically gotten rid of and is locally advanced or metastatic. Since the growth of normal body cells might additionally be affected by sunitinib, other results will occur. Before you start therapy with sunitinib, you should speak with your doctor about the benefits as well as the threats of utilizing this medication.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
5329102C22H27FN4O2398.5CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)CCCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)CInChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-WINHZLLDWRZWRT-ATVHPVEESA-NN-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide2.6398.21180428398.2118042877.263603472900001101
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