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Last Updated: 02 July 2021

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General | Latest Info

Nasopharyngeal swabs are specifically manufactured to have long, flexible shafts made of plastic or metal and tips made of polyester, rayon, or flock nylon. In addition to nasopharyngeal swabs, you will need personal protective equipment, including a gown, nonsterile gloves, protective mask, and face shield, as described below. Make sure that all sample tubes have been labelled and that appropriate requisition forms have been filled out before starting procedure. It is essential that you follow pertinent respiratory and contact precautions specified by the Centers for Disease Control and Prevention and by your own institution and that you put on PPE correctly. If possible, you should put on and take off PPE in presence of an observer to make sure there are no breaks in technique that may pose risk of contamination. First, put on a protective gown, wash your hands with soap and water, and put on a pair of nonsterile gloves. Then put on protective mask with a rating of N95 or higher, as recommended by CDC. Finally, put on face shield for face and eye protection. Masks are recommended for all patients suspected of having COVID - 19. Ask patient to take off her mask and blow her nose into tissue to clear excess secretions from nasal passages. Remove swab from packaging. Tilt patients head back slightly, so that nasal passages become more accessible. Ask the patient to close her eyes to lessen mild discomfort of procedure. Gently insert swab along the nasal septum, just above the floor of nasal passage, to the nasopharynx, until resistance is felt. Insert swab into nostril, parallel to palate. If you detect resistance to passage of swab, back off and try reinserting it at a different angle, closer to the floor of the nasal canal. Swab should reach a depth equal to the distance from nostrils to outer opening of ear. Cdc recommends leaving swab in place for several seconds to absorb secretions and then slowly removing swab while rotating it. Your institution may also recommend rotating swab in place several times before removing it. Ask the patient to reapply her mask. Open collection tube and insert swab into the tube. Break swab at groove and discard what remains of swab. Close labeled collection tube, wipe tube with surface - disinfectant wipe, and insert tube into open biohazard bag held by assistant. Depending on institutional practices, you may instead return the sample to its original packaging for transport. Follow CDC directions for direct processing of swab specimen or placement of swab in media with or without refrigeration.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

To the Editor:

Content of a video by Marty et al. It was helpful for learning how to obtain nasopharyngeal swab specimens in ordinary times. However, during the COVID - 19 pandemic, PPE has been somewhat or completely limited at hospitals in many countries. For instance, in some hospitals, it has been impossible to change gloves many times. It has also been difficult to wear appropriate PPE. It may be helpful to add information on how to save PPE while minimizing the possibility of spreading virus. Shigeo Fuji, MD, ph. D Osaka International Cancer Institute, Osaka, Japan. This letter was published on May 29 2020, on nejm.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Positive Correlations

2019, novel Coronavirus, originally outbreaking from Wuhan, China, has transmitted in an extremely short period to 25 countries and infected over 31 000 individuals AS of Feb 06 2020, causing international alarm. Basic scientific research has achieved significantly in investigation of viral origination, transmission and evolution, and unprecedented public health control actions in China have been activated and effectively prevent otherwise dramatic spread. The 2019 - nCoV virus seems more infectious in its public transmission capacity compared to the well - known 2003 SARS virus in spite of the unavailability of convincingly scientific evidence. The mechanism of viral transmission is still worthy of further exploration. Currently, one urgent and critical challenge is to treat infected patients and save their lives. Several studies have roughly described overall clinical features of 2019 - nCoV patients. However, more specific and classified clinical characteristics of infected patients still require further investigation, particularly for those with severe symptoms, which is roughly estimated to be approximately 15 - 20 percent of totally confirmed cases based on local data in our Hospital. Clinically, for those severe patients, main symptoms of 2019 - nCoV Pneumonia are fever, decreased white blood cell and lymphocyte count, increased C reaction protein and abnormally expressed cytokines. One remaining question to be resolved is whether the 2019 - nCoV virus can replicate in extra - pulmonary sites, which might account for deteriorated clinical manifestation. In this study, we investigated whether patients with severe clinical symptoms exhibit special profiles of virus replication or / and distribution compared to those only with mild symptoms. Patients, who were confirmed to be infected by the 2019 - nCoV virus, were firstly enrol in or transferred to Guangzhou Eighth Peoples Hospital for treatment purposes. This study follows guidelines of the Ethics Committee of Guangzhou Eighth Peoples Hospital. All blood, pharyngeal swab, and anal swab samples were collected for diagnostic purposes in the Laboratory and our study added no extra burden to patients. Viral RNA was extracted with Nucleic Acid Isolation Kit on automatic workstation Smart 32 following guidelines. Real - time reverse transcriptional polymerase chain reaction reagent was employed for viral detection per protocol. In brief, two PCR primer and probe sets, which target ORF1ab and N genes separately, were added in same reaction tube. Positive and negative controls were included for each batch of detection. Samples are considered to be viral positive when either or both sets give reliable signal. All patients had Pneumonia - base diseases but with diversified clinical manifestation.S To simplify data analysis, patients were only classified AS either mild or severe clinical symptom groups based on guidelines newly released by the Chinese government. Patients who were with at least one of the following symptoms should be diagnosed to be severe case, 1 distress of respiratory with respiratory rate > = 30 / min; 2 oxygen saturation < = 93% in rest state, and 3 arterial oxygen tension PaO over inspiratory oxygen fraction FIO of less than 300 mm Hg.


Results

Twenty - one patients had positive RT - PCR results but without lesions at initial chest CT. Chest CT images in 308 patients were suggestive of COVID - 19, while their RT - PCR assays from throat Swab samples were negative. Of these 308 patients, 256 had bilateral lung lesions consisting of ground - glass opacities and consolidations at chest CT. On the basis of analysis of clinical symptoms, CT features, and serial CT scans if available, 147 of 308 patients were considered as highly likely cases, 103 as probable cases, and 58 as uncertain cases.


1 INTRODUCTION

There have been 414 179 confirmed cases and 18 440 deaths caused by the ongoing global outbreak of severe acute respiratory syndrome coronavirus 2 infection as of March 26 2020. Real - time reverse transcriptase - polymerase chain reaction assay has been widely used for clinical diagnosis and SARS - CoV - 2 has been detected in specimens from multiple sites, including bronchoalveolar lavage fluid, sputum, nasal, anal, and throat swabs of patients with COVID - 19. Although lower respiratory tract samples most often test positive for viruses, testing on nasopharyngeal or throat swabs is typically used to confirm diagnosis. According to data collected by the Chinese Center for Disease Control and Prevention, 1 - 2% of Chinese confirmed cases were paediatric patients, and more than 90% of paediatric patients were mild or moderate cases. Epidemiological and clinical features of children infected with SARS - CoV - 2 infection have been reported in our previous study, and about 15. 8% of laboratory throat swab - testing confirmed cases do not have any symptoms of infection or radiologic features of pneumonia and which were admitted to hospital due to infected family members. Furthermore, several studies have recently reported that anal swabs - testing was persistently positive even after nasopharyngeal testing was negative and maybe more useful in judging the effectiveness of treatment and determining timing of termination of quarantine. Thus, we evaluate the consistency of RT - PCR assay on different types of swabs in paediatric patients through the course of SARS - CoV - 2 infection.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

PPE-Sparing, Earlier Detection?

Unsupervised home self - swab collection presents several advantages, including accessibility outside of the health care system and minimizing Personal Protective Equipment use, researchers note. This approach is safe and scalable in pandemic setting, permitting widespread testing of symptomatic participants early in illness and the potential for prompt self - isolation and contract tracing. Home - base strategy should be targeted toward individuals early in illness, when risk of transmission is highest and care seeking less likely, they add. One limit of the study is generalizability to the general public, because most participants were healthcare providers. Of note, vast majority of participants in this study were health care workers themselves, raising questions as to whether they may do a better job in collecting sample, compared to the general public, Karen Kaul, MD, PhD, chair of Department of Pathology and Laboratory Medicine At NorthShore University HealthSystem in Evanston, Illinois, tell Medscape Medical News when ask To comment on study. It is likely that clinicians would be more familiar with the swabbing process and have a better understanding of how to properly take swab, Chu say. However, people are pretty good at following instructions and collecting their own swab. This encouraging but small study examines the accuracy of self - collect mid - nasal samples for detection of COVID, in comparison to gold standard nasopharyngeal swabs collected by healthcare workers, Kaul say. This strategy would allow for broader public testing and would lessen the need for Personal Protective Equipment and healthcare workers - both of which are currently in short supply. Data show that self - collect samples yield positive results on 80% of positive samples 20% were miss, likely due to the fact that mid - nasal and nasopharyngeal swabs were being compare. Most studies show that mid - nasal swabs are somewhat less sensitive, Kaul add. She suggests that assays be performed on platform with good sensitivity to ensure that even fewer cases are miss. When asked whether self - swabbing could be used in drive - through COVID - 19 testing sites, Chu say, yes, We believe our results are generalizable to any location where swabs are being self - collect. In our study, self - collection was performed in an unsupervised home setting, with participants following a set of printed instructions. If instructions provided at these drive - through testing sites are clear and concise, we would expect the same level of accuracy. Additional limitations include possible sample degradation from shipping at ambient temperature and difference in timing of sample collection between groups self - swab cohort take 1 day longer. This timeline could have affected viral load levels, researchers note.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Some Unanswered Questions

Were facing uncertain times, dealing with a virus that still left many questions unanswered. Here is what you need to know about COVID - 19, Testing and Prevention to protect yourself and your family. Everyone. If youre exposed to novel coronavirus, you can contract it. While COVID - 19 is a very serious infection, risk to most Americans remains low. Certain groups are more susceptible to getting COVID - 19 and suffering serious complications. Older adults and people who have serious chronic medical conditions such as heart disease, diabetes and lung disease are at higher risk. If you fall into the high - risk category, it is especially important to take extra precautions and practice social distancing to prevent contracting the coronavirus. No. At this point, pregnant women are known to have a higher risk of getting sick from COVID - 19 than other adults. While pregnancy makes you more susceptible to certain infections and severe illness in general, there is no evidence to suggest higher risk associated with coronavirus. Current studies suggest there may actually be a slightly lower risk for pregnant mom of contracting coronavirus. However, if you are immunocompromised or have another serious underlying medical condition, you would be at greater risk. Covid - 19 has caused pandemics because it spread so easily. It primarily spread through respiratory droplets, which can come directly from contagious person or surface their droplets land on. The same hygiene best practices you use to prevent flu and other viruses every winter can help prevent the spread of coronavirus. These healthy habits are still your best weapons against contracting it or unknowingly spreading it to others: wash your hands for full 20 seconds. Avoid touching your face, mouth and eyes. Cover your mouth and nose when you cough or sneeze. Avoid shaking hands. Stay home when you are ill. Disinfect high - contact surfaces. Additionally, stay away from sick people. Social distancing keeps you away from those who have coronavirus or are unknowingly carrying it. Follow the latest social distancing guidelines from the Centers for Disease Control and Prevention as well as guidelines outlined by the Iowa Department of Public Health and your local community. The most common coronavirus symptoms are fever of 100 or higher combined with cough or shortness of breath. Other potential signs may include: diarrhea, Fatigue Headache, Vomiting Muscle aches, Loss of taste and smell. These symptoms can start anywhere from two to 14 days after exposure. If you are having difficulty breathing at any time and feel it is true medical emergency, call 9 - 11 or go to your nearest emergency room. Currently, there is no cure or established treatment for COVID - 19. There are many medications being trial across the country. Our providers are staying up - to - date on the latest advancements in coronavirus treatment and will use evidence - base medicine when it becomes available. However, treatment to relieve some symptoms of COVID - 19 is available. You can take acetaminophen to reduce your fever and relieve muscle aches. It is a simple nasal and oral swab test. Using an applicator, we swab you to collect sample.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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